Unit-1 PP SYBP - Solubilty factors and miscibility.pptx

physical pharmaceutics 1 unit 1 B. Pharm

1. UnIT-1: SOLUBILITY OF DRUGS PHYSICAL PHARMACEUTICS – I Second Year B. Pharm ABHISHEK JHA Assistant Professor Department of Pharmaceutics DPU Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research Sant Tukaram Nagar, Pimpri, Pune-411018

2. Contents Solubility expressions Mechanism of solute solvent interactions Ideal solubility parameters Solvation & association Quantitative approach to the factors influencing solubility of drugs Diffusion principles in biological systems Solubility of solids in liquids Raoult’s law & real solutions Partially miscible liquids Distribution law 7/19/2024

3. 7/19/2024 3 Solubility The degree to which a substance dissolves in a solvent to make a solution is called solubility A solution is a homogeneous mixture of one or more solutes dissolved in a solvent. solvent : the substance in which a solute dissolves to produce a homogeneous mixture solute : the substance that dissolves in a solvent to produce a homogeneous mixture Note that the  solvent  is the substance that is present in the greatest amount. Many different kinds of solutions exist. For example, a solute can be a gas, a liquid or a solid. Solvents can also be gases, liquids, or solids. Why solubility is important (application) Some separation methods (absorption, extraction) rely on differences in solubility, expressed as the distribution coefficient (ratio of a material’s solubilities in two solvents). Generally, solubilities of solids in liquids increase with temperature, and those of gases decrease with temperature and increase with pressure. A solution in which no more solute can be dissolved at a given temperature and pressure is said to be saturated.

4. 7/19/2024 4 Solubility SATURATED SOLUTION A saturated solution is a homogeneous mixture in which the dissolved substance (solute) is in dynamic equilibrium with its undissolved form. A saturated solution contains the maximum concentration of its solute. This maximum concentration is the solute's solubility. An undersaturated solution is one in which the solute concentration is lower than its solubility. That is, the solute concentration is lower than the concentration needed to form a saturated solution. SUPER SATURATED SOLUTION A solution that contains more of the dissolved solute that can be dissolved under normal conditions (pressure and temperature).

5. 7/19/2024 5 How Solubility is expressed Solubility can be expressed in terms of parts of solvent required to dissolve one part of solute Terms Parts of solvent required to dissolve one part of solute Very soluble Less than 1 part. Freely soluble 1 to 10 parts. Soluble 10 to 30 parts. Sparingly Soluble 30 to 100 parts. Slightly Soluble 100 to 1000 parts. Very slightly soluble 1000 to 10000 parts. Practically insoluble More than 10000 parts.

6. Solubility expressions Cont. 7/19/2024 6 PERCENTAGE % w/w %v/v %w/v MOLARITY Defined as the number of moles (or gram molecular weight) of solute dissolved in 1 liter of solution MOLALITY Defined as the number of moles (or gram molecular weight) of solute dissolved in 1 liter of solution

7. Solubility of gases in liquids 7/19/2024 7 SOLUBILITY OF GASES IN LIQUIDS It is the concentration of dissolved gas in the liquid when it is in equilibrium with the pure gas above the solution Examples Carbonated water Effervescent preparations Ammonium hydroxide Hydrochloric acid

8. FACTORS AFFECTING SOLUBILITY 7/19/2024 8 Pressure, Temperature, Presence of Salt, and Chemical reactions are a few of the major factors that affect the solubility of gases in liquids PRESSURE The effect of pressure on the solubility of gas in a liquid is explained by Henry’s law Henry’s law explains the solubility of a gas in a liquid solution by partial pressure and mole fraction of the gas in the liquid. However, this only holds true for dilute solutions and low gas pressures. It states that “ the partial pressure applied by any gas on a liquid surface is directly proportional to its mole fraction present in a liquid solvent.” Henry’s law is found experimentally to hold for all dilute solutions in which the molecular species is the same in the solution as in the gas. The most conspicuous, apparent exception is the class of electrolytic solutions.

9. 7/19/2024 9 PRESSURE cont. According to Henry ’ s law, C = κ P Where, C = Concentration of gas, κ = Henry’s law constant, which must be determined experimentally for each combination of gas, solvent, and temperature , P = Partial pressure The solubility of gases increases with the increase in the pressure of the gas in the solution. Example: O2 and N2 show this type of behavior. Gas Henry’s Law Constant [mol/( L·atm )] × 10 −4 He 3.9 Ne 4.7 Ar 15 H 2 8.1 N 2 7.1 O 2 14 CO 2 392 Henry’s Law Constants for Selected Gases in Water at 20°C

10. 7/19/2024 10 Gases that react chemically with water, such as HCl and the other hydrogen halides, H 2 S, and NH 3 , do  not  obey Henry’s law . They are much more soluble than predicted by Henry’s law. For example, HCl reacts with water to give H+( aq ) and Cl−( aq ), not dissolved HCl molecules, and its dissociation into ions results in a much higher solubility than expected for a neutral molecule. Henry’s law has important applications. For example, bubbles of CO 2 form as soon as a carbonated beverage is opened because the drink was bottled under CO 2 at a pressure greater than 1 atm. When the bottle is opened, the pressure of CO 2 above the solution drops rapidly, and some of the dissolved gas escapes from the solution as bubbles. Henry’s law also explains why scuba divers have to be careful to ascend to the surface slowly after a dive if they are breathing compressed air. At higher pressures underwater, more N 2 from the air dissolves in the diver’s internal fluids. If the diver ascends too quickly, the rapid pressure change causes small bubbles of N 2 to form throughout the body, a condition known as “the bends.” These bubbles can block the flow of blood through the small blood vessels, causing great pain and even proving fatal in some cases.

11. 7/19/2024 11 Due to the low Henry’s law constant for O 2 in water, the levels of dissolved oxygen in water are too low to support the energy needs of multicellular organisms, including humans. To increase the O 2 concentration in internal fluids, organisms synthesize highly soluble carrier molecules that bind to O 2 reversibly called hemoglobin. Hemoglobin facilitates the transport of O 2 from the lungs to the tissues. The concentration of hemoglobin in normal blood is about 2.2 mM , and each hemoglobin molecule can bind four O 2 molecules. Although the concentration of dissolved O 2 in blood serum at 37°C (normal body temperature) is only 0.010 mM , the total dissolved O 2 concentration is 8.8 mM , almost a thousand times greater than would be possible without hemoglobin. Synthetic oxygen carriers based on fluorinated alkanes have been developed for use as an emergency replacement for whole blood. Unlike donated blood, these “blood substitutes” do not require refrigeration and have a long shelf life. Their very high Henry’s law constants for O 2 result in dissolved oxygen concentrations comparable to those in normal blood.

12. 7/19/2024 12 TEMPERATURE The solubility of gases in liquids decreases with increasing temperature, as shown in Figure. Attractive intermolecular interactions in the gas phase are essentially zero for most substances. When a gas dissolves, it does so because its molecules interact with solvent molecules. Because heat is released when these new attractive interactions form, dissolving most gases in liquids is an exothermic process ( ΔH sol n < 0 ). Conversely, adding heat to the solution provides thermal energy that overcomes the attractive forces between the gas and the solvent molecules, thereby decreasing the solubility of the gas.

13. 7/19/2024 13 SALTING OUT The solubility of gases in liquids decreases with the addition of salts. Salting out is a process where the solubility of nonelectrolytes (gases/liquids) in a solvent is reduced by adding salt. This phenomenon occurs due to changes in the solvent's properties and the extent of its interactions with the solute. The salt introduces ions that strongly interact with the water molecules through ion-dipole interactions rendering the water molecules more ordered around the ions. Such rearrangement reduces the solvent a vailability to solvate the gas molecules. This is because water molecules are more strongly attracted to the ions than to the gas molecules. Also, the ionic s trength of the solution increases with the addition of salt, leading to a decrease in the solubility of non-polar gases because the ions disrupt the hydrogen-bonding network of water, making it less accommodating for the gas molecules. This leads to the gas being "salted out" of the solution, meaning it is less soluble and more likely to come out of the solution.

14. 7/19/2024 14 CHEMICAL REACTION Chemical reactions between the gas and water can significantly affect the solubility of such gases in water. Some gases like CO₂ react with water to form acids or bases, which can increase their solubility. CO ₂ + H ₂ O ⇌ H ₂ CO ₃ ⇌ H + + H CO 3 - ⇌ 2H + + CO 3 2- Certain gases like Chlorine (Cl 2 ) undergo hydrolysis when dissolved in water, forming hydrochloric acid (HCl) and hypochlorous acid ( HClO ), subsequently leading to increased solubility Cl ₂ + H ₂ O → H Cl + H Cl O Gases like Nitrogen dioxide (NO₂) can undergo redox reactions with water, forming soluble products. Nitrogen dioxide (NO₂) reacts with water to form nitric acid (HNO₃) and nitric oxide (NO), thereby increasing the solubility. 3 NO ₂ + H ₂ O →2 H N O ₃ + NO Also, the gases form hydrates when dissolved in water, which can increase their solubility. Ammonia (NH₃) reacts with water to form ammonium hydroxide that shows increased solubility NH ₃ + H ₂ O → N H ₄ OH

15. Solubility of SOLIDS in liquids 7/19/2024 15 Unlike gases, the process of the formation of a solution with a condensed phase solute is different, since there is negligible solute-solute interaction in gases. That is not the case with solids. The process comprises the following steps; Breaking Solute-Solute Interactions: In the solid state, solute particles (atoms, ions, or molecules) are held together by various forces such as ionic bonds, covalent bonds, hydrogen bonds, or Van der Waals forces For the solute to dissolve, these interactions must be overcome, which requires energy Breaking Solvent-Solvent Interactions: Solvent molecules are also held together by intermolecular forces, such as hydrogen bonds in water or Van der Waals forces in organic solvents These interactions must also be disrupted to make space for the solute particles Formation of Solute-Solvent Interactions: Once the solute particles are separated, and the solvent molecules have made space, new interactions form between the solute and solvent particles These new interactions release energy

16. 7/19/2024 16 When the crystal lattice is broken into its separate gaseous ions, the ions are surrounded by solvent molecules. The energy change associated with this overall process is the molar enthalpy of solution ΔH solution The energy change associated with assembling a lattice from its component gaseous ions is referred to as the lattice energy ( ΔH lattice enthalpy ) ΔH lattice enthalpy typically has a negative value (exothermic), indicating that energy is released to assemble ions into a lattice. The process of breaking a lattice apart is the opposite of the lattice energy and has a value of − ΔH lattice enthalpy In order to dissolve a solid, the lattice must break apart; thus, the negative of the lattice energy is used in this cycle. This energy must be added from somewhere The w ater molecules possess a dipole and are attracted to the ions on the surface of the lattice when an ionic compound is added to water The water molecules pull the ions from the surface of the compound; the ions in the solution become hydrated; they have water molecules bound to them The enthalpy change of hydration (hydration enthalpy) is defined as  the enthalpy change for the production of a solution of ions from one mole of gaseous ions or the energy released when new bonds are made between the ions and water molecules that surround them ( ΔH hydration )

17. 7/19/2024 17 ∆H solution = ∆H solvation + ∆H lattice enthalpy ∆H lattice enthalpy = ∆H 1 + ∆H 2 ∆H solvation = ∆H 3 Molecules of some other solvents, such as ethanol, are also polar and can bind to ions. When dealing with solvents other than water, the enthalpy change is referred to as the  enthalpy of solvation The sum of the negative of lattice enthalpy and hydration enthalpy is the enthalpy of the solution

18. 7/19/2024 18 Enthalpy Changes during the Formation of a Solution. Solvation can be an exothermic or endothermic process, depending on the nature of the solute and solvent. Step 1: Separation of the solvent particles, is energetically uphill (ΔH 1  > 0) in both the process. Step 2: S eparation of the solute particles (ΔH 2  > 0) Step 3: (Δ𝐻 3  < 0) because of interactions between the solute and solvent. When  Δ𝐻 3  is larger in magnitude than the sum of  Δ𝐻 1  and Δ𝐻 2 , the overall process is exothermic (Δ𝐻 𝑠𝑜𝑙𝑛  < 0) When  Δ𝐻 3  is smaller in magnitude than the sum of  Δ𝐻 1  and Δ𝐻 2 , the overall process is endothermic (Δ𝐻 𝑠𝑜𝑙𝑛  > 0)

19. 7/19/2024 19 Table: Relative Changes in Enthalpies for Different Solute–Solvent Combinations ΔH1 (separation of solvent molecules) ΔH2(separation of solute particles) ΔH3 ( solute –solvent interactions) Δ Hsoln  (Δ H1  + Δ H2 +Δ H3 ) Result of Mixing Solute and Solvent large; positive large; positive large; negative small; positive or negative solution will usually form small; positive large; positive small; negative large; positive solution will not form large; positive small; positive small; negative large; positive solution will not form small; positive small; positive small; negative small; positive or negative solution will usually form It is possible to have either ∆H 3 > (∆H 1 + ∆H 2 ) or ∆H 3 < (∆H 1 + ∆H 2 ). MgSO 4 added to water has ∆ Hsoln = –91.2 kJ/mol . NH 4 NO 3 added to water has ∆ Hsoln = + 26.4 kJ/mol. MgSO4 is often used in instant heat packs and NH4NO3 is often used in instant cold packs.

20. 7/19/2024 20 Table: Enthalpy of Solution  ΔHsol  (kJ/mol) of Some Common Electrolytes Substance Δ Hsol Substance Δ Hsol AlCl 3 (s) -373.63 H 2 SO 4 (l) -95.28 LiNO 3 (s) -2.51 LiCl(s) -37.03 NaNO 3 (s) 20.50 NaCl(s) 3.88 KNO 3 (s) 34.89 KCl(s) -17.22 NaOH(s) -44.51 NH 4 Cl(s) 14.77

21. 7/19/2024 21 The enthalpy change that accompanies a process is important because processes that release substantial amounts of energy tend to occur spontaneously. A second property of any system, its entropy, is also important in helping us determine whether a given process occurs spontaneously The entropy ( 𝑆) is a thermodynamic property of all substances that is proportional to their degree of disorder. A perfect crystal at 0 K , whose atoms are regularly arranged in a perfect lattice and are motionless, has an entropy of zero . In contrast, gases have large positive entropies because their molecules are highly disordered and in constant motion at high speeds. The formation of a solution disperses molecules, atoms, or ions of one kind throughout a second substance, which generally increases the disorder and results in an increase in the entropy of the system. Thus , entropic factors almost always favor the formation of a solution. In contrast, a change in enthalpy may or may not favor solution formation. ENTROPY AS A DRIVING FORCE FOR THE FORMATION OF THE SOLUTION

22. 7/19/2024 22 The entropy of a system increases when a solute dissolves, as it becomes more disordered as the ions spread out through the solution. An increase in entropy favours dissolving- even if a small amount of energy is needed. So substances with a small positive enthalpy change of solution are still able to dissolve, provided there is a sufficient increase in entropy. This can be used to explain why salt (NaCl) dissolves, but calcium carbonate (chalk) does not. When salt dissolves there is a large increase in entropy, which counteracts the small positive enthalpy change of solution value that it has. Calcium carbonate, on the other hand, has a small negative enthalpy change of solution; however a decrease in entropy results from it dissolving and so it is insoluble in water. The decrease in entropy occurs because the solvent, water, is becoming more ordered as the water molecules cluster around the doubly charged ions. ENTROPY OF SOLUTIONS Cont.

23. 7/19/2024 23 For example, cyclohexane and n-hexane are similar in nature and strength, and their mixture in equal amounts has ΔH soln ≈ 0 experimentally. Yet, the n-hexane and cyclohexane molecules are uniformly distributed over approximately twice the initial volume due to London dispersion forces as a driving force for solution formation due to the increased disorder in the mixture , leading to higher entropy . All spontaneous processes with  ΔH≥0  are characterized by an  increase  in entropy. In other cases, such as mixing oil with water , salt with gasoline , or sugar with hexane , the enthalpy of the solution is large and positive, and the increase in entropy resulting from solution formation is not enough to overcome it. Thus, in these cases, a solution does not form.

24. 7/19/2024 24 THE SOLVATION PROCESS Ion-Dipole Interactions: For ionic solutes (e.g., NaCl in water) , the positive and negative ions are surrounded by solvent molecules. In water, the negative oxygen ends of water molecules surround positive ions, and the positive hydrogen ends surround negative ions. Hydrogen Bonding: For solutes that can form hydrogen bonds (e.g., sugar in water) , the hydrogen bonding between solute molecules and water molecules helps to pull the solute molecules into solution. Van der Waals Forces: For nonpolar solutes in nonpolar solvents (e.g., iodine in hexane) , Van der Waals forces (induced dipole-induced dipole interactions) facilitate the dissolution. Dissolution Equilibrium: The process of dissolution reaches a dynamic equilibrium where the rate of solute particles dissolving equals the rate of solute particles re-precipitating from the solution. The concentration of solute in the solvent at this point is referred to as the solubility of the solute (SATURATION SOLUBILITY)

25. 7/19/2024 25 Temperature: Increasing temperature generally increases the solubility of solids in liquids because it provides more kinetic energy to overcome solute-solute and solvent-solvent interactions. However, for some solutes, solubility decreases with increasing temperature ( examples ahead ) Nature of Solute and Solvent: "Like dissolves like" is a general rule; P olar solutes dissolve well in polar solvents, and nonpolar solutes dissolve well in nonpolar solvents. The specific interactions (e.g., hydrogen bonding, dipole-dipole interactions) between solute and solvent molecules play a significant role. Particle Size: Smaller solute particles have a larger surface area to volume ratio, facilitating faster dissolution as there is more surface area for the solvent to act on. Presence of Other Substances: The presence of other solutes can affect the solubility of a given solute due to competition for solvation or changes in the solvent's properties. THE FACTORS AFFECTING THE SOLUBILITY OF SOLIDS IN LIQUIDS

26. 7/19/2024 26 TEMPERATURE The graph shows plots of the solubilities of several organic and inorganic compounds in water as a function of temperature. Although the solubility of a solid generally increases with increasing temperature, there is no simple relationship between the structure of a substance and the temperature dependence of its solubility. Many compounds (such as glucose and CH3CO2Na exhibit a dramatic increase in solubility with increasing temperature. Others (such as NaCl and K2SO4) exhibit little variation, and still others (such as Li2SO4) become less soluble with increasing temperature.

27. 7/19/2024 27 TEMPERATURE In the case of NH4NO3 and CaCl2, the dissolution of ammonium nitrate in water is endothermic ( ΔHsoln = +25.7kJ/mol). In contrast, the dissolution of calcium chloride is exothermic ( ΔHsoln = −68.2kJ/mol), yet the solubility of both compounds increases sharply with increasing temperature. (IF NOT enthalpy, then what drives the formation of the solut ion ; SEE ENTROPY) In fact, the magnitudes of the changes in both enthalpy and entropy for dissolution are temperature-dependent. Because the solubility of a compound is ultimately determined by relatively small differences between large numbers, there is generally no good way to predict how the solubility will vary with temperature.

28. 7/19/2024 28 PRESENCE OF OTHER SUBSTANCES The presence of other components can significantly alter the solubility of drugs through various mechanisms. These components can include other solutes, solvents, co-solvents, surfactants, complexing agents, and excipients. Here are some ways in which these components affect drug solubility: Common Ion Effect Mechanism: The addition of a common ion can decrease the solubility of a drug. This is due to the shift in equilibrium according to Le Chatelier's principle . Example: The solubility of calcium sulfate ( CaSO ₄ ) decreases in the presence of calcium chloride ( CaCl ₂) because both compounds release Ca²⁺ ions into the solution. Salt Formation Mechanism: Conversion of drugs to their salt forms can enhance their solubility. This is especially true for drugs that are weak acids or bases. Example: The solubility of the weakly acidic drug ibuprofen is significantly increased when it is converted to its sodium salt form (ibuprofen sodium).

29. 7/19/2024 29 pH Adjustment Mechanism: Changing the solution's pH can alter the drug's ionization state, affecting its solubility. Example: The solubility of weakly acidic drugs like aspirin increases in basic solutions where they are ionized , and the solubility of weakly basic drugs like codeine increases in acidic solutions where they are ionized . Co-solvents Mechanism: Co-solvents are used to enhance the solubility of drugs by altering the polarity of the solvent system. Example: Ethanol, propylene glycol, and polyethylene glycol are common. Diazepam is poorly soluble in water, but its solubility increases significantly in the presence of co-solvents like ethanol or propylene glycol, reducing the solvent system’s polarity Surfactants Mechanism: Surfactants can form micelles in solution, encapsulating hydrophobic drugs and enhancing their solubility. Example: Sodium dodecyl sulfate ( SDS ) and polysorbates (e.g., Tween 80 ) are surfactants. Cremophor EL ( polyoxyethylated castor oil) forms micelles around the hydrophobic paclitaxel to increase its solubility.

30. 7/19/2024 30 Complexation Mechanism: Complexing agents can form soluble complexes with drugs, enhancing their solubility. Example: Cyclodextrins are cyclic oligosaccharides that can form inclusion complexes with hydrophobic drugs, increasing their solubility. For instance, beta-cyclodextrin is used to enhance the solubility of drugs like itraconazole . Excipients Mechanism: Excipients in pharmaceutical formulations can affect drug solubility by altering the microenvironment pH, providing co-solvent effects, or facilitating complexation. Example: Polyvinylpyrrolidone ( PVP ) and hydroxypropyl methylcellulose ( HPMC ) are excipients that can improve the solubility of poorly soluble drugs. Hydrotropy Mechanism: Hydrotropes are compounds that increase the solubility of hydrophobic drugs by increasing the solvent's ability to dissolve them. Example: Sodium benzoate and sodium salicylate are hydrotropes that can increase the solubility of drugs like acetaminophen

31. 7/19/2024 31 The solubility of liquids in other liquids, often referred to as miscibility, is influenced by several factors. These factors determine whether two liquids can form a homogeneous mixture and the extent to which they can dissolve in each other. Here are the key factors affecting the solubility of liquids in liquids: 1. Polarity Like Dissolves Like : Polar liquids are typically soluble in other polar liquids, and nonpolar liquids are soluble in nonpolar liquids. This is due to the similar types of intermolecular forces present. Example : Ethanol (polar) is miscible with water (polar), while hexane (nonpolar) is miscible with benzene (nonpolar). 2. Intermolecular Forces Hydrogen Bonding : Liquids that can form hydrogen bonds tend to be soluble in other hydrogen-bonding liquids. Example : Water and methanol can form hydrogen bonds with each other, leading to mutual solubility. SOLUBILITY OF OF LIQUIDS IN LIQUIDS

32. 7/19/2024 32 Dipole-Dipole Interactions : Polar liquids with significant dipole moments are soluble in each other due to dipole-dipole attractions. Example : Acetone and chloroform both have dipole moments and are miscible. Van der Waals Forces : Nonpolar liquids rely on Van der Waals (dispersion) forces for solubility. Example : Nonpolar liquids like toluene and hexane are miscible. 3. Temperature Temperature Increase : Generally, an increase in temperature can increase the solubility of liquids in one another due to increased molecular motion and interaction. Example : The solubility of oil in water slightly increases with temperature, although they are largely immiscible. 4. Pressure Volatile Liquids : For mixtures involving volatile liquids, pressure can affect solubility, especially near the boiling point. Example : The solubility of gases in liquids increases with increasing pressure (Henry's Law), but this is less relevant for liquid-liquid solubility.

33. 7/19/2024 33 5. Nature of the Solvent and Solute Molecular Size and Shape : Similar-sized and shaped molecules are often more soluble in each other. Example : Ethylene glycol and glycerol are both polar and similarly structured, leading to high mutual solubility. Functional Groups : The presence of functional groups that can interact (e.g., hydroxyl, carboxyl) increases solubility. Example : The hydroxyl groups in ethanol and water enhance their miscibility through hydrogen bonding. 6. Presence of Other Substances Co-solvents : The addition of a third component (co-solvent) can enhance solubility by altering the solvent environment. Example : The solubility of phenol in water increases with the addition of acetone as a co-solvent. 7. Impurities : Impurities can either increase or decrease solubility, depending on their nature and interaction with the primary liquids. Example : Adding a salt to a water-alcohol mixture can change the solubility dynamics due to ion-dipole interactions.

34. 7/19/2024 34 Examples and Applications Ethanol and Water Polarity and Hydrogen Bonding : Both ethanol and water are polar and can form hydrogen bonds, making them completely miscible in all proportions. Temperature Effect : The miscibility remains high across a wide range of temperatures, demonstrating a strong hydrogen bonding network. Oil and Water Polarity : Oil is nonpolar, while water is polar, resulting in immiscibility due to the lack of significant intermolecular interactions. Temperature Effect : Temperature changes have minimal impact on their immiscibility because the fundamental intermolecular force disparity remains. Acetone and Water Polarity : Acetone is polar and can form hydrogen bonds with water, making them miscible. Co-solvent Addition : Adding a nonpolar solvent like hexane can decrease acetone’s solubility in water by disrupting hydrogen bonding.

35. 7/19/2024 35 Eutectic mixtures are homogeneous mixtures of two or more components that, at certain compositions, exhibit a lower melting point than any of the individual components or any other mixture of the same substances. This unique composition is known as the eutectic composition, and the temperature at which it melts is called the eutectic temperature. Eutectic mixtures are characterized by the simultaneous crystallization of all components at the eutectic temperature. Characteristics of Eutectic Mixtures Lower Melting Point : The eutectic mixture has a melting point lower than any of the pure components or other mixtures of the same substances. Simultaneous Crystallization : At the eutectic temperature, all components of the mixture crystallize together from the liquid phase. Definite Composition : The eutectic composition is fixed for a given mixture and is independent of the initial proportions of the components. EUTECTIC MIXTURES

36. 7/19/2024 36 Examples of Eutectic Mixtures Salt and Water (Freezing Point Depression) A common example of a eutectic mixture is the combination of salt (sodium chloride, NaCl ) and water . The eutectic temperature for this mixture is -21.2°C , and it occurs at a specific concentration of salt in water. This principle is used for de-icing roads, where salt is spread to lower the melting point of ice, causing it to melt at lower temperatures. Bismuth and Tin (Solder) Bismuth (Bi) and tin (Sn) can form a eutectic mixture that melts at 139°C , which is lower than the melting points of either pure bismuth (271°C) or pure tin (232°C) . This eutectic mixture is used in soldering because it melts and solidifies at a relatively low temperature, which is beneficial for joining metal components without damaging them. Menthol and Camphor Menthol and camphor can form a eutectic mixture that melts at a lower temperature than either component alone. This mixture is used in topical formulations for its cooling and soothing properties.

37. 7/19/2024 37 4. Ibuprofen and Paracetamol In the pharmaceutical industry, a eutectic mixture of ibuprofen and paracetamol can be formed. This mixture has a lower melting point than either of the individual drugs 5. Lidocaine and Prilocaine Lidocaine and prilocaine form a eutectic mixture used in topical anesthetics (e.g., EMLA cream). The eutectic mixture melts at a lower temperature, allowing the cream to be applied at room temperature and providing effective local anesthesia. Importance and Applications Pharmaceuticals : Eutectic mixtures can improve the solubility and bioavailability of drugs. Metallurgy : Eutectic alloys are used in applications requiring low melting points, such as soldering and casting. Food Industry : Eutectic principles are used in the formulation of certain frozen desserts and in the preservation of foods through freezing.

38. 7/19/2024 38 Eutectic Point on Phase Diagrams The eutectic point is represented on a phase diagram, which plots temperature against composition. The phase diagram of a eutectic system typically shows: Liquidus Lines : Above these lines, the mixture is entirely liquid. Solidus Lines : Below these lines, the mixture is entirely solid. Eutectic Point : The intersection of the liquidus lines at the eutectic composition and temperature, where the mixture transitions directly from liquid to a solid phase of both components.