Ventilation final

1. VENTILATION Dr. Amith Sreedharan

2. DEFINITION ANATOMY OF THE AIRWAYS DISTRIBUTION OF VENTILATION PULMONARY PRESSURES MECHANICS OF BREATHING FACTORS AFFECTING VENTILATION SPIROMETRY VOLUMES CONTROL OF BREATHING ABNORMAL VENTILATION REFERENCES

3. DEFINITION Mass movement of gas in and out of the lungs

4. ANATOMY Nostrils ( Nares ) Transfer air back and forth between the outside environment and the Nasal Cavity. These structures serve as the primary air intake site.

5. Nasal Cavity A chamber that transfers air and gases back and forth between the nostrils and the pharynx. Air is warmed and humidified – temp rises to within 1⁰ F of body temperature and to within 2-3 % of full saturation with water vapour before it reaches trachea. Partially filtered- turbulent filtration(>6 micron) Clinical significance

6. Pharynx The throat passage way that allows air and gases to pass back and forth between the nasal cavity and the glottis. During inspiration,pressure in pharynx fall below atm.pressure Opposed by pharyngeal dilator muscles( genioglossus and tensor palati ) Patency in supine position maintained by tensor palati,palatoglossus and palatopharyngeus

7. Epiglottis A flap-like structure in the lower pharynx that is located above the glottis. The epiglottis operates like a valve that allows air to pass through the glottis and into the trachea during breathing, but, closes over the glottis during the swallowing of food and drink to prevent choking.

8. Glottis An opening that allows air to pass back and forth between the pharynx and the larynx during breathing A set of cartilaginous structures and membranes that allow air to pass back and forth between the glottis and the trachea. The larynx ( voicebox ) also contains cord-like membranes that produce sounds. Larynx

9. WIEBEL MODEL

10. Trachea Generation 0 Length 11 cm Mean diameter 1.8 cm A tube reinforced by a series of u-shaped cartilaginous rings that passes air back and forth between the larynx and the primary bronchi . Lined by ciliated columnar epithelium

11. Main Bronchus Generation 1 A tubular structure that passes air back and forth between the trachea and lobar bronchi 2 in nos Mean diameter – 12 mm Irregular shaped cartilage present in the walls The epithelial lining- ciliated columnar

12. LOBAR BRONCHI Generation 2 – 3 5-8 in nos Mean diameter 5 mm – 8mm Supply lobes Irregular shaped cartilages

13. Segmental Bronchi Generation 4 16-20 in nos Supplies segments A tubular passageway that passes air back and forth between a lobar bronchus and the remainder of a bronchial tree ( third, fourth, fifth degree branches, etc. ). Mean diameter 4 mm

14. Terminal Bronchiole Generations 5 - 16 One of the smallest tubular passageways in the lung that passes air back and forth between the smallest bronchial tube and the respiratory bronchiole . Mean diameter 0.7mm Cuboidal epithelium Strong helical muscle bands in the wall

15. Respiratory Bronchiole Generations 17- 19 Transitional and respiratory zone The smallest air tubes in the lungs that passes air back and forth between a terminal bronchiole and an alveolar sac . Mean diameter 0.4mm Cuboidal to flat epithelium

16. ALVEOLAR DUCTS Generation 20,21,22 Along with alveoli forms the lung parenchyma Mean diameter 0.3 mm Lined by alveolar epithelium Thin bands of muscle in alveolar septa

17. Alveolar Sac Generation 23 Last generation of air passage A sac-like (blind) extension of a respiratory bronchiole that is divided into many small alveolar compartments. The alveolar sac will contain many small septa that act as partitions between the alveoli. The septa and alveolar surfaces provide surface area for gas exchange . 17 alveoli arise from each alveolar sac

18. Alveolus The smallest site in the lung for gas exchange. Made up of a thin membrane that is ideal for diffusion of gases back and forth between the air of the alveolar sac and the blood of pulmonary capillaries . 270 – 790 million Mean diameter at FRC = 0.2 mm

19. Pulmonary acinus Aka primary lobule/terminal respiratory unit Zone supplied by first order respiratory bronchioles,alveolar ducts and alveolar sacs distal to a single terminal bronchiole. 30000 acinus present in human lung Diameter = 3.5mm Contain > 10000 alveolus

20. DISTRIBUTION OF VENTILATION Influenced by POSTURE and MANNER OF VENTILATION. Right lung > L eft lung (larger size) Lateral position : lower lung more ventilated Horizontal slices: uppermost portion one third ventilated as base. Preferential ventilation only present at inspiratory flow rates below 1.5 L/S.(N=0.5 L/S) At high rate,uniform distribution.

21. Minute Ventilation Total volume of air entering and leaving respiratory system each minute Minute ventilation = V T x RR Normal respiration rate = 12 breaths/min Normal V T = 500 mL Normal minute ventilation = 500 mL x 12 breaths/min = 6000 mL /min

22. Alveolar Ventilation Volume of air reaching gas exchange areas per minute Alveolar Ventilation = (V T x RR) – (DSV x RR) Normal Alveolar Ventilation = (500 mL / br x 12 br /min) – (150 mL / br X 12 br /min) = 4200 mL /min

23. DEAD SPACE An appreciable part of each inspiration do not penetrate to those regions of gas exchange and therefore exhaled unchanged. This fraction of Tidal volume(Tᵥ) = DEAD SPACE Alveolar ventilation(V A ) : Effective part of minute volume of respiration. Alveolar ventilation= respiratory rate × (Tᵥ - dead space) RATIOS VD/VT = Wasted portion of breath VA/MV = utilised portion of MV

24. COMPONENTS OF DEAD SPACE APPARATUS DEAD SPACE: First part to be exhaled if subject is employing any form of external breathing apparatus. ANATOMICAL DEAD SPACE: Volume of the conducting air passages ALVEOLAR DEAD SPACE: Part of inspired gas that passes through anatomical dead space to mix with gas at alveolar level , but does not take part in gas exchange.

25. ANATOMICAL DEAD SPACE FACTORS INFLUENCING : Size of subject – increases with size Age – from adulthood increases 1 ml/year. Posture - 150 ml sitting,100 ml supine Position of neck and jaw Neck extended,jaw protruded-143 ml Normal position – 119 ml Neck flexed,chin depressed – 73 ml Lung volume at end of inspiration- 20 ml additional An.DS/each litre increase in LV Tracheal intubation,tracheostomy,LMA - decreased An.DS Drugs With Decreased Tidal volume, An.DS decreases

26. ALVEOLAR DEAD SPACE FACTORS INFLUENCING: CARDIAC OUTPUT PULMONARY EMBOLISM POSTURE

27. PHYSIOLOGICAL DEAD SPACE Sum of all parts of Tidal volume that do not participate in gaseous exchange Sum of anatomical dead space and alveolar deadspace . 30 % of tidal volume Factors influencing: Age and sex Body size (17ml / every 10 cm ↑) Posture (↓ es in supine) Pathology (PE,SMOKING)

28. PULMONARY PRESSURES Atmospheric pressure = P atm I ntra-alveolar pressure = P alv Pressure of air in alveoli Intrapleural pressure = P ip Pressure inside pleural sac Transpulmonary pressure = P alv – P ip Distending pressure across the lung wall

29. Atmospheric Pressure 760 mm Hg at sea level Decreases as altitude increases Increases under water Other lung pressures given relative to atmospheric (set P atm = 0 mm Hg)

30. Intra-alveolar Pressure Pressure of air in alveoli Given relative to atmospheric pressure Varies with phase of respiration During inspiration = negative (less than atmospheric) During expiration = positive (more than atmospheric) Difference between P alv and P atm /(Pₐₒ) drives ventilation

31. Factors determining intra-alveolar pressure Quantity of air in alveoli Volume of alveoli Lungs expand – alveolar volume increases P alv decreases Pressure gradient drives air into lungs Lungs recoil – alveolar volume decreases P alv increases Pressure gradient drives air out of lungs

32. Intrapleural Pressure Pressure inside pleural sac Always negative under normal conditions Always less than P alv Varies with phase of respiration At rest, -5 mm Hg(MEAN)

33. Negative pressure due to elasticity in lungs and chest wall Lungs recoil inward Chest wall recoils outward Opposing pulls on intrapleural space Surface tension of intrapleural fluid hold wall and lungs together

34. Transpulmonary Pressure Transpulmonary pressure = P alv – P ip Distending pressure across the lung wall Increase in transpulmonary pressure: Increase distending pressure across lungs Lungs (alveoli) expand, increasing volume

35. Pressure-volume curves of the lung during inspiration and expiration . HYSTERESIS

36. PARABOLIC (LAMINAR) FLOW PROFILE

37. PATTERNS OF AIRFLOW Laminar flow. Turbulent flow. Transition flow

38. Inspiration of air into trachea via mouth and nose. Accomplished by inspiratory chest wall muscle contraction.

39. TRUNK / CHEST WALL RIBCAGE ABDOMEN Separated by DIAPHRAGM

40. DIAPHRAGM Membranous muscle separating abdominal cavity and chest SA = 900 cm² Most important inspiratory muscle Motor innervation : Phrenic N(C3,4,5) Contraction Increase in lung volume

41. MECHANICS OF DIAPHRAGM MOVEMENT ‘ Piston in cylinder ’ Analogy ‘ Non piston ’ behaviour Combination (piston + non piston) Combination of all the above mechanisms and change in shape involving ‘ tilting and flattening ’ of diaphragm in AP direction.

42. RIBCAGE MUSCLES RIBCAGE = CYLINDER/BUCKET Length governed by DIAPHRAGM And secondarily by flexion and extension of Spine CROSS SECTION By movement of RIBS

43. MECHANICS OF RIBCAGE MUSCLES ‘BUCKET HANDLE’ ACTION ‘PUMP HANDLE’ MOVEMENT

44. Intercostal muscles External intercostals Deficient anteriorly Primarily inspiratory Internal intercostals Deficient posteriorly (less powerful) Primarily expiratory Parasternal portion is inspiratory . Intercostalis intima Posture plays important role in ICM action. Extreme postural changes reverts activity of intercostal muscles

45. ACCESSORY MUSCLES Silent in normal breathing Increased ventilation(about 50 L/min) leads to recruitment of ACCESSORY muscles. MUSCLES Generally inspiratory Sternocleidomastoid M Pectoralis minor M Serrati M Extensors of vertebral column ABDOMINAL M Generally expiratory Rectus abdominis Obliques – external and internal Transversalis Muscles of pelvic floor(supportive)

46. INSPIRATION Ribcage inspiratory muscles ( ext & parasternal int ICM ) and Diaphragm act in parallel to inflate the lungs. Scalene muscles (supportive role) POSTURE decides the dominant role Diaphragm contraction alone results in widening of lower ribcage and indrawing of upper ribcage countered by IC and neck muscle

47. EXPIRATION No musculature required in quiet breathing in supine position Elastic recoil of lungs provide energy required for expiration and is also aided by weight of abdominal contents In upright position and stimulated ventilation the INTERNAL ICM and Abdominal wall M are active in returning the ribcage and Diaphragm to resting position

48. EFFECT OF POSTURE ON MUSCLES UPRIGHT : In Standing/Sitting position , Ribcage muscles more used(67 % contribution) Scalene and parasternal internal ICM support SUPINE :Diaphragm upward(4 cm up) Decreased FRC Fibre length decreased in supine position More effective contraction LATERAL : Only lower dome of Diaphragm pushed higher into chest,upper dome is flat. Lower dome contract effectively Increased ventilation of lower lung.

49. CHEMORECEPTOR ACTIVATION Respiratory muscle response to hypoxia / hypercarbia for an equivalent minute volume. Hypoxia stimulates mostly inspiratory muscles Hypercapnea stimulates both inspiratory and expiratory muscles. NEXT

50. Factors Affecting Pulmonary Ventilation Lung Compliance Airway Resistance

51. Lung Compliance Ease with which lungs can be stretched  V Lung Compliance =  ( Palv – Pip) Larger lung compliance Easier for inspiration Smaller change in transpulmonary pressure needed to bring in a given volume of air FACTORS AFFECTING COMPLIANCE Elasticity More elastic  less compliant Surface tension of lungs Greater tension  less compliant

52. Surface Tension in Lungs Thin layer fluid lines alveoli Surface tension due to attractions between water molecules Surface tension = force for alveoli to collapse or resist expansion To Overcome Surface Tension Surfactant secreted from type II cells Surfactant = detergent that decreases surface tension Surfactant increases lung compliance Makes inspiration easier

53. Resistance to airflow < 1 cm H₂O pressure gradient (alveolar to atmospheric pressure) sufficient to cause enough airflow for quiet breathing Greatest amount of resistance to airflow is not in minute air passages of terminal bronchioles but in some larger bronchioles and bronchi near trachea. In disease,smaller bronchioles play a greater role in determining airflow resistance because of small size and they are easily occluded by Muscle contraction in their walls Edema occuring in walls Mucus collecting in lumen

54. Nervous and local control of bronchial musculature Sympathetic dilation of bronchioles Direct control relatively weak because few fibers penetrate central portions of lung Cause dilation of bronchioles Parasympathetic constriction Few parasympathetic fibers penetrate lung parenchyma Also activated by local irritation(noxious gases,infection ) Local factors – histamine,SRS -A

55. FACTORS AFFECTING LUNG VOLUME

56. LUNG VOLUMES

57. Tidal volume (TV): The tidal volume (TV) is the volume of air that is drawn into the lungs during inspiration from the end-expiratory position (and also leaves the lungs passively during expiration in the course of quiet breathing).

58. Inspiratory reserve volume (IRV): Maximum volume of air inspired from the end-tidal inspiratory level. Expiratory reserve volume (ERV): The expiratory reserve volume (ERV) is the maximum volume of air that can be forcibly exhaled after a quiet expiration has been completed (i.e., from the end-expiratory position). Residual volume: The residual volume (RV) is the volume of air that remains in the lungs after a maximal expiratory effort. always left in lungs, even with forced expiration. Not measured with spirometer

59. The functional residual capacity (FRC) is the volume of air that remains in the lungs at the end of a normal expiration. The inspiratory capacity (IC) is the maximum volume of air that can be inhaled from the end-expiratory position . It consists of two subdivisions : tidal volume and the inspiratory reserve volume (IRV).

60. The total lung capacity (TLC) is the total volume of air contained in the lungs at the end of a maximum inspiration. The vital capacity (VC) is the volume of air that is exhaled by a maximum expiration after a maximum inspiration . So in total there are 4 volumes and 4 capacities.

61. Centres Voluntary Control --- Motor Cortex 2. Involuntary (autonomic) Control --Brain Stem Pons Medulla Oblongata Medulla contains two centres of breathing Inspiratory Centre containing inspiratory neurones Expiratory Centre containing expiratory neurones For quiet breathing (eupnoea); I neurones responsible for inspiration; expiration when I neurones cease firing. I neurones cease (probably) by a “slow loop negative feedback” mechanism During exercise (hyperpnoea) I neurones inhibited by Pneumotaxic centre in the Pons region

62. Medullary Respiratory Centre Two regions: 1) Dorsal respiratory group(DRG) – Inspiratory Centre 2) Ventral respiratory group(VRG) – Expiratory Centre • Probable that cells of the inspiratory centre have the property of “intrinsic periodic firing” - responsible for the basic rhythm of ventilation • With all stimuli abolished inspiratory cells generate repetitive bursts of action potentials - nervous impulses along efferent nerves to respiratory muscles

63. Expiratory Centre Quiescent during normal quiet breathing In exercise hyperpnoea when breathing is more forceful, expiration becomes active due to the expiatory neurones. Pneumotaxic Centre(PRG) - Upper Pons Appears to switch off inspiration and so regulate inspiratory volume and respiration rate. Apneustic Centre Neurones are suggested to have an excitatory effect on the inspiratory neurones prolonging the ramp action potentials

64. Respiratory Reflexes pH of body fluids/plasma is the most potent stimulus to the respiratory centre ↓ pH > ↑ pCO 2 > ↓ pO 2 Detected by 1. Peripheral Chemoreceptors aortic bodies carotid bodies 1) Small highly perfused shunts of the main arteries 2) Sensory (afferent) signals to medulla by, vagus ( ao ) and glossopharyngeal (ca) 3) pH is the predominant trigger. pO 2 less important except at altitude or in disease

65. CHEMORECEPTORS

66. Central Chemoreceptors Surface of the Medulla Oblongata • Measure pH of cerebrospinal fluid (CSF) and brain tissue fluid • Main aim of respiratory control is brain pH homeostasis Hydrogen ions [H + ] do not freely pass blood/CSF barrier • But CO 2 does easily (no lactic acid effect on central chemoreceptors ) • In CSF CO 2 + H 2 O = H + + [HCO 3 ] - H + liberated then influences the central chemoreceptors

67. BRAIN STEM PHRENIC AND INTERCOSTAL NERVES MOTOR NEURONS RESPIRATORY MUSCLES LUNGS NEUROMUSCULAR JUNCTION VENTILATION

68. ABNORMALITIES APNEUSTIC BREATHING occurs with lesions of the pons and is characterized by prolonged inspiratory duration. KUSSMAUL BREATHING Seen in ketoacidosis Virtually no pause between breaths(air hunger) GASPING RESPIRATION(CEREBRAL HYPOXIA) Irregular,quick inspirations associated with extensions of the neck and followed by a long expiratory pause.

69. Cheyne -Stokes breathing is one form of periodic breathing characterized by a cyclic rise and fall in ventilation with recurrent periods of apnea or near apnea . Hyperapneic phase more than apneic phase Supramedullary lesions( tegmentum of pons ) Biot’s breathing tidal volumes of fixed amplitude are separated by periods of apnea . Apneas may be separated by periods of gradually increasing and decreasing breathing

70. REFERENCES FISHMAN’S PULMONARY DISEASES AND DSISORDERS CROFTON AND DOUGLAS’S RESPIRATORY DISEASES NUNN’S APPLIED RESPIRATORY PHYSIOLOGY GUYTON’S TEXTBOOK OF PHYSIOLOGY GANONG REVIEW OF PHYSIOLOGY PLEURAL DISEASES - LIGHT

71. THANK YOU