Vitamin E toxicity

Vitamin E toxicity

1. Vitamin E toxicity
Domina Petric, MD

2. Vitamin E toxicity
Vitamin E is one of the least toxic of the
vitamins.
Dailydoses as high as 400 IU can be
considered harmless.
Largeoral doses as great as 3200 IU have
notbeenfound to have consistent ill effects.
April 11, 2018
Combs GF. The Vitamins. Fundamental Aspects in
Nutrition and Health. Elsevier Inc. 2008.
2

3. Vitamin E toxicity
•At very high doses, however, vitamin E can
antagonize the functions of other fat-soluble
vitamins.
•This can be antagonised with increased dietary
supplements of the appropriatevitamins:vitamins D,
A and K.
•Isolated reports of negative effects inpatients
consuming up to 1000 IU of vitaminE per day
included headache, fatigue, nausea, double vision,
muscularweakness, mild creatinuriaand
gastrointestinal distress.
April 11, 2018
Combs GF. The Vitamins. Fundamental Aspects in
Nutrition and Health. Elsevier Inc. 2008.
3

4. Fat soluble vitamins
April 11, 2018
Combs GF. The Vitamins. Fundamental Aspects in
Nutrition and Health. Elsevier Inc. 2008.
4
Vitamin AVitamin E
Vitamin K
Vitamin D
Fat soluble
vitamins

5. Vitamin E toxicity
April 11, 2018
Combs GF. The Vitamins. Fundamental Aspects in
Nutrition and Health. Elsevier Inc. 2008.
5
DOUBLE
VISION
HEADACHE
FATIGUE
NAUSEA
MUSCULAR
WEAKNESS
CREATINURIA
GASTROINTESTINAL
DISTRESS
Vitamin E
intoxication
The least
toxic of
vitamins
Individual
cases
Dose >1000
IU/day

6. Vitamin E toxicity
•Potentially deleterious metabolic effects of
highlevel vitamin E status include inhibitions
of retinylester hydrolase and vitamin K-
dependent carboxylations.
•Patientsofnormal coagulation status given
high doses of vitamin E (at least 1000 IU/day)
showed decreased γ-carboxylation and
decreased functionality of prothrombin.
April 11, 2018
Combs GF. The Vitamins. Fundamental Aspects in
Nutrition and Health. Elsevier Inc. 2008.
6

7. Vitamin E toxicity
Tocopherylquinonehas
structural similarities to
vitamin Kandmay act as
an inhibitor ofvitamin K
metabolism.
April 11, 2018
Combs GF. The Vitamins. Fundamental Aspects in
Nutrition and Health. Elsevier Inc. 2008.
7

8. Conclusion
VitaminE is safe over a
wide range of intakes that
would extend to
approximately 1600 IU/day
for most healthy adults.
April 11, 2018
Combs GF. The Vitamins. Fundamental Aspects in
Nutrition and Health. Elsevier Inc. 2008.
8

9. Literature
•Combs GF. The Vitamins. Fundamental Aspects in
Nutrition and Health. Elsevier Inc. 2008.
April 11, 2018 9