VitaminC its functions, its sources and its deficiency.pptx

VitaminC its functions, its sources and its deficiency

1. V I T A MI N C Dr. Shivani Pandey, Department of Biochemistry, K.G. Medical University, Lucknow

2. Vitamin C Vitamin C - known as ascorbic acid - is a water-soluble vitamin. Unlike most mammals, humans do not have the ability to make their own vitamin C. Therefore, we must obtain vitamin C through our diet. Fun fact: " ascorbic acid " comes from the New Latin " scorbutus " meaning scurvy! FIGURE 1 Chemical structure of ascorbic acid. Dr. Shivani Pandey, Department of Biochemistry

3. Vitamin C - Ascorbic Acid Structure Metabolism oxidation/reduction dehydroascorbic acid d e h y d r oa s c o r b a t e reductase glutathione (GSH) g l u t am at e - c y s t e i n e - glycine Dr. Shivani Pandey, Department of Biochemistry

4. Vitamin C - F un c t i o n s Synthesis of collagen, an important structural component of blood vessels, scar tissues, tendons, ligaments, and bone. Synthesis of the neurotransmitters, norepinephrine critical to brain function and are known to affect mood. Highly effective antioxidant protects proteins, lipids (fats), carbohydrates, and nucleic acid (DNA and RNA) from damage by free radicals. Regenerates other antioxidants such as vitamin E. Vitamin C enhances the synthesis of immunoglobulins (antibodies) and increases the phagocytic action of leucocytes.

5. Vitamin C - F un c t i o n s vitamin C is required for the synthesis of carnitine, a small molecule that is essential for the transport of fat to mitochondria, for conversion to energy. Enhances absorption of iron reduces iron to more absorbable ferrous form chelates with ferrous ion to make it more soluble Synthesis of corticosteroid hormones: Adrenal gland possess high levels of ascorbic acid, particularly in periods of stress, it is believed that vitamin C is necessary for the hydroxylation reactions in the synthesis of corticosteroid hormones.

6. Sources [4] Food Serving (Vitamin C (mg Orange juice ¾ cup (6 ounces) 75 Grapefruit juice ¾ c u p ( 6 oun ce s ) 60 Orange 1 medium 70 Grapefruit ½ medium 44 Strawberries 1 cup, whole 82 Tomato 1 medium 23 Sweet red pepper ½ cup, raw chopped 141 Broccoli ½ cup, cooked 58 Potato 1 medium, baked 26 Dr. Shivani Pandey, Department of Biochemistry

7. Vitamin C - RDA About 60-70mg vitamin C in take per day will meet the adult requirement. Additional intakes (20-40% increase ) are recommended for women during pregnancy and lactation.

8. Vitamin C Deficiency Disease result from severe vitamin C deficiency Scurvy Cardiovascular Disease Stroke Cataracts Lead toxicity Dr. Shivani Pandey, Department of Biochemistry

9. Dr. Shivani Pandey, Department of Biochemistry S c u r v y Bleeding gums petechiae easy bruising impaired wound healing and bone repair joint pain anemia