Zinc pyrithione

1. Kumar Organic Products Limited
Product Information
Antidandruff Active Ingredient
Contents
• Introduction
• Product Data
• Anti-microbial properties
• Clinical Study
• Benefits of Zinc Pyrithione
• Our Export Destinations
• Product Specification
Kumar Organic Products Limited
Usha Krishan Centre, No.819/C, 13
th
Cross, 7
th
Block (West)
J.S.S. College Circle, Jayanagar, Bangalore 560082, Karnataka, India.
Ph : 00 91 80 – 41525960, 080-41425832 Fax : [phone]
Email : [email protected]
Zinc Pyrithione 50% FPS

2. INTRODUCTION
The first antidandruff shampoo containing Zinc Pyrithione was launched
almost four decades ago. Since then Zinc Pyrithione bactericide-fungicide has
become the worlds leading antidandruff agent. It also used as an antibacterial
agent in Dermatological creams and ointments.
Combination of efficacy and safety has made it most effective antidandruff
agent for several decades.
It effectively does the job any antidandruff agent is expected to do i.e.
relieving the flaking and itching symptoms of dandruff. Its lasting
properties make Zinc Pyrithione a superior one, meaning it sticks and
remains active on the scalp, so it’s effectiveness lasts from one use to the
next.

3. PRODUCT DATA
Structural Formula
N S
Zn
N
O
S
O
Zinc-2-Pyridinethiol-1-Oxide
Zinc Pyrithione is actually Zinc complex of Pyrithione which
is 2-Pyridine thiol-1-oxide. Under chemical abstracts registry
it is named as bis[1-hydroxy-2(1H)-Pyridinethionato-O,S]-(T-
4)Zinc (CAS No: 13463-41-7). The molecular and structural
formulae are C
10
H
8
N
2
O
2
S
2
Zn and

4. Physical Properties
Description : Off – White color, stable aqueous dispersion
free from sign of impurities
Odor : Mild, Characteristic odor
Assay ( % ZPT ) : 48% - 50%
Zinc Content : 09.3 to 11.3 %
pH ( 5% Slurry in pH 7 water ) : 6.5 to 9.0
Particle size : 90% < 1 Micron
Solubility Properties
Water : 0.01% Max
Ethanol : 0.02% Max
Methanol : 0.03% Max
Chloroform : 0.10% Max
Ether : 0.01% Max

5. Heat Stability :
It is stable at 100°c for at least 120hrs. Around 240°c it undergoes decomposition.
pH : Stability :
Zinc Pyrithione is quite stable over the pH range from 4 – 10. Below 4.5 the
Zinc complex starts dissociating, forming free Pyrithione. Above pH 9.5 the
Zinc complex undergoes hydrolysis to give ionized Pyrithione
Light Stability :
Zinc Pyrithione undergoes gradual decomposition when exposed to light
Stability Study

6. Minimum Inhibitory
Concentration(mcg/gm)
Staphylococcus aureus 6.3
Escherichia Coli 12.6
Bacillus Subtillus 6.3
Pytyrosporum Ovale 6.3
Trichophyton 12.5M
ic
r
o
o
r
g
a
n
is
m
s
Anti-microbial properties of ZPT:
Data shows very low concentrates of Zinc Pyrithione inhibits
the growth of many micro-organisms
Zinc Pyrithione, an effective biocide with anti Pityrosporum
activity, eliminates P.ovale the causative organism of dandruff
and maintains good personal hygiene.

7. In – House Clinical Study
Clinical trial to study the efficacy and safety of Anti-dandruff shampoo containing
1.0% of Zinc Pyrithione was conducted on 20 male volunteers with moderate to
severe dandruff for 04 weeks
S.noNo.of peoplePercentageReduction in dandruff in %
1 16 80 90
2 2 10 80
3 1 5 75
4 1 5 60
Results of Clinical Trials
S.No
Isolation of P.ovale
in culture before
treatment
%
Isolation of P.ovale
in culture after
treatment
%
1 20 100 NIL 0
After 04 weeks of product usage it was not possible to isolate P.ovale in culture
from all the volunteers.
Non of them complained of any adverse effects like pruritus, erythema, hair fall or local
discomfort
there was definite reduction in dandruff (White powder / flakes in the scalp) in all the volunteers

8. World wide Clinical Study
This graphic shows the clinical studies success rates of SKIN
CARE in the treatment of severe skin disorders

9. This therapy represents one of the best advances in the treatment of psoriasis.
- Abbott Northwestern Hospital, USA
Positive effects in 95.5% of the treated cases. Good anti-inflammatory effect. No
side effects. Disappearance of itches. No irritations. Very good results in dermatitis
and neurodermatitis.
- State University of Medicine of Siberia
Positive effects were observed, with decrease of inflammation, itching and flaking.
ZINC PYRITHIONE spray can be recommended for the treatment of psoriasis,
dermatitis, seborrhea rosacea and eczema.
Centre for the Medical and Social Rehabilitation of Children Affected by Allergodermatitis,
RUSSIA,
ZINC PYRITHIONE spray is a very effective and safe treatment, specially
reducing flaking and plate erythema in patients affected by common psoriasis
- University of Buenos Aires
Good and very good results from the 6th day of treatment. Very good results,
above all with spray and shampoo. Good absorption. Absence of side effects.
Effective alternative for the treatment of psoriasis.
University Hospital of Dermatology
- University Hospital of Dermatology
Conclusion of different Clinical Research of ZPT Formulation

10. Benefits of Zinc Pyrithione
An effective, practically nontoxic antidandruff active ingredient
Suitable for the manufacture of antidandruff shampoos
and hair care products such as hair tonics and cream rinses
with an antidandruff action
Low concentration is required.
No side effects : Safe and effective antidandruff agent
It produced dramatic healing effects on skin lesions produced
by psoriasis, dandruff, eczema, ringworm, fungus, athletes
foot, dry skin, atypical dermatitis, tinea etc.

11. End Use / Formulations
• As an antidandruff agent in Shampoo
• Effective antibacterial – Anti fungal agent in derma – Cream
Spray and Soap.
• Highly effective in Dandruff control, Psoriasis,
Seborrheic Dermatitis, Other Dermatitis and Eczema

12. Our Export Destinations
Asia
-China
-Philippines
-Indonesia
-Thailand
-Taiwan
-U.A.E.
-Iran
-Vietnam
Europe
-United Kingdom
-France
Latin America
-Brazil
-Argentina
-Venezuela
-Columbia
-Guatemala
Africa
-South Africa
-Kenya
America
-USA
-Canada

13. Sl.No. Properties Limits
1Description Off - White colour, Stable Aqueous dispersion free from signs of impurity.
2Identity Confirms
3Odour Mild, Characteristic odour.
4Assay 48-50%
5Zinc content 9.3 –11.3%
6PH ( 5% Slurry in pH 7 water )6.5-9.0
7Particle size by Malvern 90% < 1 Microns
8Iron 10ppm max as Fe
9Arsenic 5 ppm max as As
10Lead 5 ppm max as Pb
11Chromium 3 ppm max as Cr
12Cobalt 3 ppm max as Co
13Nickel 5 ppm max as Ni
14Mercury 1 ppm max as Hg
Microbiological Test
1.    Total plate count/g Less than 100
(Including yeast and mold)
2.    E.coli/g Negative
3.    S.Aureaus/g Negative
4.    Pseudomonas/g Negative
5. Enterobacteria/g
Negative
15
Product Specification - Zinc Pyrithione
Kumar Organic Products Limited

14. Kumar Organic Products Limited
Usha Krishan Centre, No.819/C, 13
th
Cross, 7
th
Block (West)
J.S.S. College Circle, Jayanagar, Bangalore 560082,
Karnataka, India.
Ph : 00 91 80 – 41525960, 080-41425832 Fax : 91 80
-26715688
Email : [email protected]