3-Drug Absorption and it's Distribution.pptx

Informative note on drug absorption and distribution.

1. Drug Absorption and Distribution

2. 2 Drug Absorption The process of movement of unchanged drug from the site of administration to systemic circulation The effectiveness of a drug can only be assessed by its concentration at the site of action.

3. 3 Drug Distribution Reversible transfer of drugs between one compartment and another ( between blood & extravascular fluids & tissues)

4. 4 Drug Distribution Permeation of free or unbound drug into interstitial / extracellular fluid Permeation of drug present in extracellular fluid into intracellular fluid { rate limiting step}

5. 5 Cell 5

6. 6 Plasma Membrane Fluid mosaic model : Working model of the membrane Protein molecules bobbing in phospholipid sea Proteins determine membrane’s specific functions 6

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10. 10 MECHANISMS OF DRUG ABSORPTION

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19. 19 • It is a form of endocytosis in which small particles are brought to the cell, forming an invagination . • These small particles are suspended in small vesicles. • It requires energy in the form of ATP. • This process is important in the absorption of oil soluble vitamins & in the uptake of nutrients 19