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1. CORRELATION OF ABG ABNORMALITIES WITH CLINICAL SEVERITY IN OPC POISONING Research topic by DR. ARUN MURALEEDHARAN 1st year Postgraduate General medicine GUIDE -Dr Rathnakumar MD CO GUIDE -Dr Sivasubramanian MD

2. Introduction - Organophosphorus (OP) compounds are a wide variety of chemicals derived from phosphoric, phosphonic, and phosphinic acids, primarily used as pesticides .

3. study aims to assess whether ABG results correlate with clinical outcomes and the degree of toxicity, aiding in timely management and better prognostic assessment.

4. Objective To assess the correlation between ABG abnormalities and clinical severity in OP poisoning

5. Methods - Design: Cross-sectional study - Location: Tirunelveli Medical College Hospital in department of general medicine intensive medical care unit - Period: 6 months - Sample size : 58 patients

6. Inclusion criteria Patient included in this study are 1.Age 1 8 to 7 years 2.Ingestion of OPC poison within past 48 hours

7. Exclusion Criteria Patients with liver disease , renal disease Alcohol intoxication Mixedpoisoning Other substance abuse Uncontrolled hyperglycemia

8. Data collection Arterial blood samples collected within [X] hours of admission • ABG parameters analyzed: pH, pCO₂, pO₂, HCO₃⁻, lactate • Clinical severity classified using a validated scoring system (e.g., Peradeniya OP Poisoning Scale)

9. POP classification

10. mild: score 0-3; moderate: score 4-7 and severe: score 8-11

11. Expected outcome Arterial blood gas (ABG) analysis is a valuable tool in the early assessment of OP poisoning severity. Abnormal ABG parameters, particularly metabolic acidosis, respiratory failure (hypercapnia/hypoxemia), and low bicarbonate levels, are significantly associated with more severe clinical presentations. Patients with deranged ABG findings tend to have increased requirements for ventilatory support, longer hospital stays, and higher mortality risk. • Routine use of ABG analysis on admission may aid in early risk stratification, guide intensive care decisions, and improve clinical outcomes.

12. REFERENCES 1. Peter JV, Moran JL, Graham PL. Clinical features of organophosphate poisoning: A review of 1,000 cases. Clinical Toxicology. 2007;45(6):627–633. 2. Eddleston M, Buckley NA, Eyer P, Dawson AH. Management of acute organophosphorus pesticide poisoning. Lancet. 2008;371(9612):597–607. 3. Bardin PG, Van Eeden SF, Moolman JA, Foden AP, Joubert JR. Organophosphate poisoning: Grading the severity and comparing treatment between atropine and glycopyrrolate . Crit Care Med. 1987;15(6):516–522. 4. Churi S, Bhakta K, Mengi S. Evaluation of ABG parameters in acute OP poisoning. Indian Journal of Critical Care Medicine. 2013;17(3):144–149. 5. Karalliedde L, Senanayake N. Organophosphorus insecticide poisoning. British Journal of Anaesthesia. 1989;63(6):736–750