Absolute bioavailability & relative bioavailability

Difference between Absolute bioavailability and Relative bioavailability

1. ABSOLUTE BIOAVAILABILITY & RELATIVE BIOAVAILABILITY PRESENTED BY : Mahesh Gomasa PharmD-IV year BHARAT SCHOOL OF PHARMACY Hyderabad PRESENTATION ON

2. ABSOLUTE BIOAVAILABILITY : It is determined for the same drug in variuos formulations. Measurement of actual percetage of the adminisered (non-intravenous)dose,which is absorbed intact into the systemic circulation relative to equivalent IV dose. 1) 2)

3. Compares drug exposures following extravascular administration of the tested dose form with that of an intravenous administration. Used to charecterise a drug’s inherent absorption properties from extravascular site. Example : Comparative study of bioavailability of a drug given through oral route and IV route. 3) 4)

4. RELATIVE BIOAVAILABILITY : 4 It is determined for the various drugs Measure of fraction of a given drug that is absorbed intact into systemic circulation from a dosage form relative to an established standard dosage form ofthat drug. Compare bioavailability of a formulation(X) of the same drug (usually established standard) 1) 2) 3)

5. Used to charecterise absorption of a drug from its formulation 5 Example : Generic formulation is compared with a standard formulation of same drug in same dosage form. 4)

6. REFERENCES : 6 Www.Amrita Akhouri.com www.Google.com

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