Acetate pathway

Acetate pathway introduction

1. Acetate pathaway . ASST.PROF ROHIT PRADIP MALI NGSPM COP, NASHIK.

2. Content Introduction Pathway description

3. Introduction It is one of the most important metabolic pathway for synthesis of secondary Metabolites. The pathways start with acetyl CoA so known as acetate pathway. From this acetate 2 pathways are form (i) Acetate mevalonate pathway/ Isoprenoid pathway (ii) Acetate melonate pathway This pathways are starting using end product of glycolysis cycle I.e acetyl CoA its active form of acetate.

4. Pathway description Glycolysis Acetate mevalonate pathway Pyruvate Acetyl CoA Acetate melonate pathway

5. Acetate mevalonate pathway gives Mevalonic acid and it gives Isoprenoids ( Steroids and Terpenoids) Acetate melonate pathway gives Malonyl CoA intermediate Gives fatty acids lipids ( Fat and waxes)

6. 1. Acetate Mevalonate Pathway/lsoprenoid pathway :Isoprenoid represent functionally and structurallythe most diverse group metabolite. The "biogeneticisoprene rule" is the basis for formation of variousisoprenoid compounds such as rubber, monoterpenes,sesquiterpenes, sterol, triterpenes, diterpenesUniversal precursor for all isoprenoids is Isopentenylpyrophosphate (IPP) and dimethylallyl pyrophosphate(DMAPP) and biosynthesis of these precursor takesplace in mavalonic acid pathway.The 5-carbon isomersisopentenyl pyrophosphate (IPP) and dimethylallylpyrophosphate (DMAPP) are the fundamental buildingblocks used to synthesize key biological isoprenoids(terpenoids) including cholesterol and other steroids,carotenoids, saponins, and limonoids.

7. 2 . Acetate malonate pathway- The main productsof the acetate-malonate pathway are the fattyacids, both those primary metabolites which occuruniversaly and the more unusual compounds with arestricted distribution. This pathway also makes animportant contribution to plant aliphatic and aromaticcompounds, which are biosynthesised through theformation of polyketides

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