Acetate pathway, acetate Mevalonate pathway/ Isoprenoid pathway. Mevolinic acid pathway

ACETATE PATHWAY, Acetate Mevalonate pathway/ Isoprenoid pathway : Formation of terpenes & steroids. Acetate Melonante Pathway: Formation of Fatty acids and Polyketides,

1. Vth Semesester B. pharmacy Pharmacognosy and Phytochemistry-II Unit-I Basic Metabolic Pathway (Part-3) (Acetate Pathway) Presented By : Miss. Pooja D. Bhandare (Assistant Professor) Kandhar College of Pharmacy, Nanded

2. ACETATE PATHWAY It is also one of the important pathway for the synthesis of different types of secondary metabolites cells of plant. Why it is know as acetate pathway?: As starting material utilizes in this pathway is acetate. This Acetate is utilize in the form of Acetyl Co-A. As t is the active form of acetate.

3. Acetate occupy central position in relation to general metabolism, From this only different metabolic pathway originated for the biosynthesis of different secondary metabolites. Different straight chain compounds and aromatic compounds get biosynthesized from this acetate by different metabolic pathway.

4. Acetate pathway have two main route : that means there is mainly 2 main pathway in which this acetate is utilized a starting material. Acetate Mevalonate pathway/ Isoprenoid pathway : Formation of terpenes & steroids. Acetate Melonante Pathway: Formation of Fatty acids and Polyketides

5. Glycolysis Pyruvate Acetyl CoA Acetate Mevalonate Pathway Acetate Melonate Pathway Mevalonic acid Malonyl CoA Isoprenoids Stroids Squalene Terpenes Fatty acids Lipids (fat & Waxes

6. Acetate Mevolnate Pathway/ Mevalonic acid Pathway/Isoprenoids Pathway/ Methylerythritol Pathway Contribute 1/3 rd know secondary metabolite One of the most important intermediate formed or utilized in this pathway is Mevalonate that is mevalonic acid. This mevalonate or mevalonic acid i.e intermediate which synthesize in this pathway, this mevalonate only further used for the synthesis of terpenoids. Terpenoids are derived from isoprene units which are joined in head-to-tail or head-to head .

7. The mevalonate pathway are used by nature to prepare Dimethylallyl Pyrophosphate(DMAPP) and Isopentenyl Pyrophosphate(IPP).

8. Acetate Melonante Pathway Polyketide constituent a large class of natural products grouped together on purely biosynthetic pathways. Their diverse structures can be explained as being derived from poly- β -keto chains formed by coupling of acetic acid (C2) units via condensation reactions. Included in such compounds are fatty acids, polyacetylenes, prostaglandins, macrolide antibiotics and many aromatic compounds, e.g., anthraquinones and tetracyclines.

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