Acrochordon_MetS_Phhhhhhhhhhroposal.pptx

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1. Title Slide Association between Acrochordons and the Components of Metabolic Syndrome: A Hospital-Based Cross-Sectional Study

2. Introduction Acrochordons (skin tags) are benign fibroepithelial polyps. Traditionally seen as cosmetic, but linked with obesity, diabetes, and metabolic syndrome. Metabolic Syndrome (MetS): cluster of risk factors (obesity, hypertension, dyslipidemia, hyperglycemia).

3. Literature Review Kahana et al. (1987): Skin tags as cutaneous markers for diabetes. El Safoury et al. (2011): Association with leptin, insulin resistance, MetS. Akpinar & Dervis (2012): Significant link with dyslipidemia. Das et al. (2021, India): 23% of patients with acrochordons had MetS. Gap: No Nepal-based hospital studies available.

4. Statement of the Problem Skin tags are common but often disregarded. They may indicate underlying systemic metabolic derangements. No local studies in Nepal exploring this association.

5. Rationale & Significance If acrochordons are linked to MetS, they can be a low-cost, visible marker for early detection. Helps dermatologists and general practitioners identify high-risk individuals. Supports preventive strategies against diabetes and cardiovascular disease.

6. Objectives General: To study the association between acrochordons and components of metabolic syndrome. Specific: 1. Determine prevalence of MetS among patients with acrochordons. 2. Assess distribution of MetS components. 3. Compare with controls without acrochordons.

7. Methodology Design: Hospital-based cross-sectional comparative study. Cases: Patients with acrochordons. Controls: Age/sex-matched without acrochordons. Inclusion: Adults ≥18 years. Exclusion: Patients with known metabolic disease, on steroids/insulin, pregnant women.

8. Sample Size Calculation Cochran's formula with prevalence 30%, CI 95%, margin of error 5%. n = 323. With 10% non-response = 359 cases + 359 controls.

9. Data Collection & Analysis Data tools: Proforma, anthropometry, BP, fasting glucose, lipid profile. Definitions: Acrochordon = fibroepithelial polyp; MetS = ≥3 criteria (NCEP ATP III). Analysis: SPSS v25, chi-square, t-test/Mann-Whitney, logistic regression. p <0.05 significant.

10. Ethical Considerations & Limitations Ethical approval from IRC. Informed consent from participants. Confidentiality maintained. Limitations: Hospital-based (not community), cross-sectional (no causality), recall bias possible.

11. Conceptual Framework Acrochordons (Exposure) → Associated with → Components of Metabolic Syndrome (waist circumference, hypertension, dyslipidemia, hyperglycemia).

12. References Kahana et al. (1987) Thappa (1995) Bhargava et al. (1996) El Safoury et al. (2011) Shaheen et al. (2012) Akpinar & Dervis (2012) Agamia & Gomaa (2014) Das et al. (2021) Shenoy et al. (2016)