Analytical and post analytical errors in laboratory

Laboratory Errors committed usually resulting to erroneos result.

1. ANALYTICAL AND POST-ANALYTICAL ERROR IN CLINICAL CHEMISTRY LABORATORY Hanisha Erica P. Villaester , RMT

2. Analytical Errors

3. Analytical Errors Test System Not Calibrated Results reported when control results out of range Improper measurements of specimens and/or reagents Reagents prepared incorrectly Reagents stored inappropriately or used after expiration date Instrument maintenance not dance Dilution and pipetting errors

4. Analytical Errors Inaccuracy Imprecision Errors Insensitivity Linearity Issues

5. Analytical Errors Inaccuracy Invalidates reference ranges and cut-off points May lead to inappropriate therapy or failure to treat May lead to misdiagnosis May lead to failure to diagnose Imprecision Issues Poor reproducibility invalidates patient monitoring using laboratory results

6. Analytical Errors Insensitivity A change in assay sensitivity leads to issue of detection Affects robustness of results near the detection limit Linearity Issues A clear understanding of the linearity of a method is essential to ensure that grossly inaccurate results are not reported where there are high concentrations or activities of analytes

7. Post-Analytical Errors

8. Post-Analytical Error Transcription errors in reporting Report sent to the wrong location Report illegible Report not sent

9. Summary Pre-Analytical Errors 46 – 68.2% Insufficient sample Sample condition Sample handling Incorrect Identification Incorrect sample Analytical Error 7 – 13.3 % Equipment Malfunction Sample Mix up Interference Post-Analytical 18.5 – 47 % Reporting and Interpreting Improper date entrye

10. Impact of Errors Inadequate or improper patient care Inconvenience to patient Misdiagnosis Harm to patient Death

11. WHAT SHOULD WE DO? Develop systematic workflow Identify critical processes Continuous monitoring Predict accidental events so preparation may be ahead Strengthen defences and decrease vulnerability

12. References Odell, M. (Feb 2014). CSE Senior Design 1. Retrieved from https ://www.google.com.ph/url?sa=t&rct=j&q=& esrc=s&source=web&cd=35&cad=rja&uact=8&ved=0CDUQFjAEOB5qFQoTCNL0jbC99MYCFYUmlAodnY8CvQ&url=http%3A%2F%2Franger.uta.edu%2F~odell%2FCSE_4316_Senior_Design_I%2FCSE%25204316%2520Classic%2520Mistakes.ppt&ei=946yVZKdLIXN0ASdn4roCw&usg=AFQjCNFgWECvcwF_hLS-nwPKhoXuOs0cAA&bvm=bv.98476267,bs.1,d.c2E