Antiangina drug

Anti anginal drug with its classification.

1. Anti anginal Drugs by Shaikh Saniya b.pharm

2. Angina pectoris, the principal symptom of heart disease is characterized by a severe constricting pain in the chest radiating from the pericardium to the left shoulder and down the arm. The principal goal in prevention and relief of angina is to limit the oxygen requirement of the heart so that the amount of the blood supplied by the arteries is adequate.

3. Angina Pectoris

4. Stable Angina Pain due to atherosclerosis causing incomplete coronary artery occlusion. Pain onset with strenuous activity or emotional strain due to increased myocardial oxygen demand.   Unstable Angina Pain due to atherosclerotic plaque rupture and subsequent embolization causing incomplete coronary arterial occlusion.   Variant ( Prinzmetal's ) Angina Pain due to transient vasospasm causing coronary artery vasoconstriction.

5. Atherosclerosis

6. Balloon Therapy

7. Signs of Heart Attack Sweating Nausea or Throwing UP Shortness of Breath Dizziness Fainting Chest Pain or Discomfort Pain moving down the left ARM Pain moving up to the left side of the JAW Pain or discomfort in your back or stomach

8. nitrates The action of short acting sublingual nitrates in the relief of angina is complex. Organic nitrates, nitrites ,nitrous compounds and variety of other nitrate compounds cause their pharmacological effect by generating or releasing nitric oxide. Nitroglycerine is an effective anti anginal agent because it causes redistribution of coronary blood flow to the ischemic region of heart and reduces myocardial oxygen demand.

9. Calcium is essential for contraction. Calcium increase in ischemia because of membrane depolarization that leads to hypoxia which promotes activity of ATP consuming enzyme. This causes decrease of energy. Calcium channel blockers inhibits the entrance of calcium into tissues such as cardiac smooth muscle. Therefore all calcium channel are vasodilators that causes decrease in smooth muscle tone and vascular resistance .

10. β - blockers They act by reducing cardiac work, and oxygen consumption. More importantly , beta blockers limit increase in these modalities that occurs during exercise or anxiety. All beta blockers are effective in decrease frequency and severity of attacks.

11. Potassium channel opener The increased potassium reflux from smooth muscles cell induced by the potassium channel opener is accompanied by reduced intracellular availability of free calcium, which turn induces vascular relaxation. This property is being exploited to achieve , peripheral and coronary artery dilatation in patients with ischemic heart disease.

12. Aspirin is contraindicated in following patients

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