Antiscabies and antipedicular agents

Antiscabies and antipedicular agents

1. ANTISCABIOUS AND ANTIPEDICULAR AGENTS Definition Benzyl benzoate, Lindane , Permethrin , Crotomiton Mr. Naga Prashant Koppuravuri , M.Pharm ( Ph.D ), FAGE., Assistant Professor, Department of Pharmaceutical Chemistry.

2. SCABICIDES Are agents used to control mite Sarcoptes Scabei . An organism that thrives under conditions of poor personal hygiene.

3. PEDICULOCIDES Are used to eliminate lice from head, body and crab. Ideal Scabicides and pediculocides must kill the adult parasites and destroy their eggs.

4. 1. Benzyl Benzoate Naturally occuring esterObtained from Peru balsam And other resins. Effective scabicide when applied topically Immediate relief from itching probably results from a local anaesthetic effect

5. Applied topically as a lotion over the entire dampened body, except face. Complete cure is achieved with single application of 25% emulsion of benzyl benzoate in single application.

6. 2. LINDANE 1,2,3,4,5,6-hexachlorocyclohexane Halogented hydrocarbon is prepared by chlorination of benzene. A mixture of 5 isomers have been isolated in this process.( α , β , γ , δ , ε )

7. Isomer γ is responsible for the activity. Is employed locally as a cream, lotion or shampoo for the treatment of Scabies and pediculosis . The action is of threefold Direct contact poison. Has a fumigant effect Acts as a stomach poison.

8. 3.CROTAMITON N-methyl-N-(2-methylphenyl)-2-butenamide. Available in 10% concentration in a lotion and a cream intendes for the topical treatment of Scabies.

9. 4.PERMETHRIN Synthetic pyrethrenoid compound. More stable than natural pytethrins . 4 isomers are Present. Commercial Product is a racemic mixture

10. It exerts a lethal action against lice, ticks, mites & fleas. Acts on the nerve cell membranes of the parasites to disrupt sodium channel conductance. Pediculocide for the treatment of head lice. A single application of a 1% solution is known to give the effect.