Neuro Protective Effect And Attenuation Of Dementia
Neuro protective effect and attenuation of dementia by diltiazem in ICV STZ induced sporadic
Alzheimer s disease rat model. Ramesh Alluri* Sivamallikarjuna Reddy A Supriya Reddy G Cognitive
Science Research Initiative Lab, Dept. of Pharmacology, Vishnu Institute of Pharmaceutical Education
and Research, Narsapur, Medak Dist., Telangana, 502313. Correspondence:
[email protected] Abstract: Sporadic Alzheimer s disease is an age related neurological and
psychiatric disorder characterized by impaired energy metabolism. Oxidative stress and neuro
inflammation have been implicated in pathophysiology of sporadic type of dementia. The Intra
cerebroventricular (ICV) administration of streptozotocin induces behavioural and biochemical
alterations resembling those in sporadic type of Alzheimer s patients. The present study was designed
to investigate the effects of chronic pre treatment with non competitive calcium channel inhibitor
diltiazem on cognitive dysfunction and oxidative stress markers in intra cerebroventricular (ICV)
streptozotocin treated albino rats. Chronic treatment with diltiazem low dose 20mg/kg and 40 mg/kg
orally on a daily basis for a period of 21 days, beginning 1 h prior to intra cerebroventricular
streptozotocin injection, significantly improved streptozotocin induced cognitive impairment. Besides,
improving cognitive dysfunction, chronic administration of highly selective calcium channel blocker
diltiazem, reduced elevated malondialdehyde,
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