𝐃𝐞𝐟𝐢𝐧𝐢𝐭𝐢𝐨𝐧
𝐀𝐬𝐭𝐡𝐦𝐚 is a chronic inflammatory airway disease characterized by recurrent episodes of wheezing, shortness of breath, chest tightness, and cough.
𝐀𝐧𝐚𝐭𝐨𝐦𝐲 𝐨𝐟 𝐍𝐨𝐫𝐦𝐚𝐥 𝐚𝐧𝐝 𝐀𝐬𝐭𝐡�...
𝐃𝐞𝐟𝐢𝐧𝐢𝐭𝐢𝐨𝐧
𝐀𝐬𝐭𝐡𝐦𝐚 is a chronic inflammatory airway disease characterized by recurrent episodes of wheezing, shortness of breath, chest tightness, and cough.
𝐀𝐧𝐚𝐭𝐨𝐦𝐲 𝐨𝐟 𝐍𝐨𝐫𝐦𝐚𝐥 𝐚𝐧𝐝 𝐀𝐬𝐭𝐡𝐦𝐚𝐭𝐢𝐜 𝐀𝐢𝐫𝐰𝐚𝐲𝐬
In normal airways, the smooth muscle surrounding the airways is relaxed, allowing for unobstructed airflow.
In asthmatic airways, the smooth muscle is hyperreactive, constricting more easily in response to various stimuli.
𝐜𝐚𝐮𝐬𝐞𝐬
• Exposure to allergens such as dust mites, pollen, mold, and pet dander
• Exposure to air pollutants such as cigarette smoke and secondhand smoke
• Viral respiratory infections
• Occupational exposure to irritants or chemicals
𝐏𝐚𝐭𝐡𝐨𝐩𝐡𝐲𝐬𝐢𝐨𝐥𝐨𝐠𝐲
. When an individual with asthma is exposed to an allergen or irritant, their immune system mounts an exaggerated inflammatory response, leading to bronchoconstriction, airway edema, and mucus plugging.
𝐓𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭 𝐎𝐩𝐭𝐢𝐨𝐧𝐬
• Inhaled corticosteroids (ICS): The mainstay of long-term asthma control
• Long-acting beta2-agonists (LABAs): Provide bronchodilation for extended periods
• Leukotriene modifiers: Block the action of leukotrienes, inflammatory mediators involved in asthma
𝐓𝐲𝐩𝐞𝐬
• Allergic asthma: Triggered by exposure to specific allergens
• Non-allergic asthma: Not triggered by specific allergens but may be exacerbated by environmental irritants, infections, or exercise
• Occupational asthma: Caused by exposure to workplace irritants or allergens
𝐂𝐨𝐦𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬
• Frequent asthma attacks requiring emergency care
• Hospitalization due to severe asthma exacerbations
• Impaired lung function and reduced quality of life
• Increased risk of respiratory infections
• Psychological distress and anxiety
𝐏𝐫𝐞𝐯𝐞𝐧𝐭𝐢𝐯𝐞 𝐌𝐞𝐭𝐡𝐨𝐝𝐬
• Identifying and avoiding personal triggers
• Maintaining a healthy lifestyle, including regular exercise and a balanced diet
• Controlling allergies and managing environmental exposures
• Getting regular vaccinations, especially flu and pneumonia vaccines
• Adhering to prescribed asthma medications and treatment
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Language: en
Added: Sep 07, 2024
Slides: 42 pages
Slide Content
Asthma
PPT
Disease
Name
Asthma
By
Disease
Name
Asthma
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Definition
Asthma is a chronic lung
disease affecting people
of all ages. It is caused by
inflammation and muscle
tightening around the
airways, which it harder
to breathe. makes
According to WHO
Add reference here 6
Prevalence
7
Asthma
Add reference here 8
•According to WHO Asthma affected an estimated 262 million
people in 2019 (1) and caused 455 000 deaths.
Age-standardized prevalence of asthma per 100,000 population in 2019
Add reference here 9
oPersistent cough, especially at night
oWheezing during exhalation and sometimes inhalation
oShortness of breath or difficulty breathing
oChest tightness, hindering deep breaths
Common symptoms
Causes
Asthma
Irritants Outdoor allergens Viruses Indoor allergens
Add reference here 12
Triggers of asthma include:
Colds, weather changes, dust, smoke, fumes, pollen, animal dander, and certain chemicals can trigger
Asthma
Pathogenesis
Pathogenesis
Allergens are picked up
bydendritic cells.
Dendritic Cells present
them to aType 2
Helpercell.
T-Cell
Dendritic Cell
Allergen
Add reference here 14
Asthma
Pathogenesis
TH2cell
producescytokineslike
IL-4
IL-4 leads the production
ofIgEantibodies which
coatmast cells.
T-Cell
IL4
IgE
Antibodies
Mast Cell
Histamine
Leukotriene
Stimulate them to release
granules containing things
likeHistamine& leukotrienes.
Add reference here 15
Asthma
Pathogenesis
TH2cell
producescytokineslik
e IL-5.
IL-5, on the other hand,
activates eosinophils.
This promotes an immune
response by releasing
morecytokines and
leukotrienes.
IL5
T-Cell Eosinophil
Cytokines
Leukotrienes
Add reference here 16
Asthma
Asthma Pathogenesis
Allergens are picked up
bydendritic cells which present
them to aType 2 Helpercell.
Dendritic
Cell
T-Cell
Allergen
T-Cell IL4
IgE
Antibodies
Mast
Cell
Histamine
Leukotriene
TH2 cells produceIL-4
leads the production of IgE
antibodies which coatmast cells to
release histamines & leukotrienes.
IL-5 activateseosinophils
which release morecytokines
& leukotrienes.
IL5T-Cell Eosinophil
Cytokines
Leukotrienes
Add reference here 17
Asthma
Pathogenesis
Dendritic cell
TH2-cell
Allergen
IL5 IL4
IgE
Antibodies
Mast Cell
Histamine
Leukotriene
Eosinophil
Cytokines
Leukotrienes
TH2cell producecytokines like IL-4 and IL-5
IL-5, on the other hand, activateseosinophils
which release morecytokinesand leukotrienes.
Allergens are picked up bydendritic cells which
present them to aType 2 Helpercell.
IL-4 leads the production ofIgEantibodies
which coat mast cellsand release histamines &
leukotrienes.
Add reference here 18
Explore the animated pathogenesis of asthma
Normal vs. Asthma
Air Air
Normal Asthma
Mucus
Proin ipsum nibh,
condimentum sed
pellentesque ac, pretium.
Lorem ipsum dolor sit amet,
consectetuer adipiscing elit.
Maecenas portico cangue masa.
Add reference here 19
Asthma Pathogenesis
1
Swelling
2
Airway narrows
3
Airflow Decreases
4
Extra Mucus
5
Tightening of muscles
Bronchi
Air
Mucus
Add reference here 20
1c
Risk Factors
Asthma
Family historyObesity
AgeSmoking
Add reference here 24
Source : WHO 25
Factors Increasing the Risk of Asthma
•Family history: Asthma is more likely in individuals with a family
history, especially among close relatives like parents or siblings.
•Allergic conditions: People with other allergies, such as eczema or
rhinitis, are more prone to asthma.
•Urbanization: Living in urban areas is associated with a higher risk of
asthma due to various lifestyle factors.
•Early life events: Factors like low birth weight, prematurity, exposure to
tobacco smoke, air pollution, and viral infections can increase the risk.
•Environmental exposures: Exposure to allergens and irritants, such
as indoor and outdoor air pollution, house dust mites, molds, and
occupational exposures, can contribute to asthma.
•Obesity: Overweight or obese individuals have a higher risk of
developing asthma.
Asthma
Diagnosis
Asthma
Diagnosis
Allergy testing
Skintest or ablood test
Arterial blood gas
In a severe asthma attack
Chest x-ray
To rule out other conditions
Lung function tests
peak flow measurements
Add reference here 27
Diagnosis
Asthma
Lung function
tests
quis metus.
Nullam ac
Allergy
test
metus aliquam
urna finibus.
Arterial
blood gas
sagittis. Nam
non metus arcu
Chest x-ray
Lorem ipsum
dolor sit amet,
Add reference here 28
Asthma
Types
Asthma
Types
Nocturnal asthma
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Non allergic asthma
Add text
Allergic asthma
Add text
Adult-onset asthma
Add text
Occupational asthma
Add text
Cough variant asthma
Add text
Childhood onset asthma
Add text
Aspirin induced asthma
Add text
Asthma Types
Add reference here 31
Nocturnal asthma
Add text
Non allergic asthma
Add text
Allergic asthma
Add text
Adult-onset asthma
Add text
Occupational asthma
Add text
Cough variant asthma
Add text
Childhood onset asthma
Add text
Aspirin induced asthma
Add text
Asthma Types
Add reference here 32
Asthma
Treatment
Add reference here 34
•Medication therapy: Your healthcare provider
may prescribe medications to manage asthma
symptoms.
oBronchodilators:
Relax airway muscles, facilitating airflow and
mucus movement. Used for both intermittent
and chronic asthma.
oAnti-inflammatory medicines:
Reduce inflammation and mucus production,
improving airflow. Often prescribed daily for
chronic asthma control.
oBiologic therapies:
Used for severe asthma, unresponsive to inhaler
therapy.
Asthma Management Options
Add reference here 35
Asthma Treatment
•Medication administration:
Asthma medications can be administered
through various methods, including:
oOral medications:
Swallowed medications
prescribed by your
healthcare provider.
oInhalers: Metered-dose
inhalers, nebulizers, and
other asthma inhalers.
Add reference here 38
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