aziz sancar nobel prize winner: from mardin to nobel

aziz sancar nobel prize winner

1. Unlocking the Mysteries of Life: The Nobel Journey of Aziz Sancar İsa Badur. PhD-MSc

2. Dr. Aziz Sancar B orn in 1946 in Mardin , Turkey, is a biochemist renowned for his extraordinary contributions to DNA repair mechanisms. In 2015, he was awarded the Nobel Prize in Chemistry

3. factors that can damage DNA, such as radiation, chemicals, and errors during replication.

4. DNA repair mechanisms: direct reversal, excision repair, and double-strand break repair.

5. photolyase enzyme direct reversal: photoreactivation, which is the repair of UV-induced cyclobutane pyrimidine dimers (CPDs) by photolyase enzymes.

6. Excision repairnucleotide excision repair (NER) the process of nucleotide excision repair. This mechanism acts like a proofreader, identifying and excising damaged sections of DNA and then replacing them with pristine nucleotides. This groundbreaking work laid the foundation for understanding how cells maintain the integrity of their genetic information.

7. Double-strand break repai r- homologous recombination (HR) Aziz Sancar also contributed to the understanding of HR in bacteria and demonstrated how it can increase genetic diversity and adaptation.

8. Human DNA repair human DNA repair is more complex and regulated than bacterial DNA repair, due to the presence of multiple chromosomes, histones, and cell cycle checkpoints.

9. DNA repair and human health DNA repair is essential for human health and that defects in DNA repair can lead to various diseases, such as cancer, aging, and neurodegeneration diseases that are caused by mutations in DNA repair genes, such as xeroderma pigmentosum, Cockayne syndrome, and hereditary nonpolyposis colorectal cancer. DNA repair can also be exploited for therapeutic purposes, such as by enhancing the sensitivity of cancer cells to chemotherapy or radiation

10. Circadian Rhythms and DNA repair discovering photolyase, elucidating repairnucleotide excision repair (NER) , and developing a molecular clock for circadian rhythms.

11. His honors in 40 years Gairdner International Award, the Vehbi Koç Award, and the Presidential Medal of Science.

12. References https://www.nobelprize.org/prizes/chemistry/2015/sancar/lecture/ https://www.meb.gov.tr/sancar-interest-shown-to-me-in-turkiye-is-more-important-than-winning-ten-nobel-prizes/haber/25272/en