Biology Of Cancer Submitted To - dr. monika asthana submitted BY – Prashant sharma POOJA GUPTA
What is cancer? Cancer is the abnormal proliferation of any of the different kind of cell. Cancer - Latin word which means “Crab”
Oncology Study of cancer Onco - Greek word which means Tumor Tumor Tumor is uncontrolled growth of cell.
Types of Tumors
Types of Cancers On the basis of cell type On the basis of tissue of origin
On the basis of cell type
On the basis of tissue of origin Fibro-sarcoma - in fibroblast Erythoid leukemia - in RBC
Development of Cancer
Causes of Cancer Radiations Chemicals Viruses
Tumor Viruses
Properties of Cancer Cells Less adhesive Secrete Proteases Angiogenesis Fail to undergo Apoptosis Loss of Density dependent inhibition Autocrine growth stimulation Loss of Contact Inhibition Defective Differentiation
Density Dependent Inhibition
Autocrine Growth Stimulation
Contact Inhibition
Defective Differentiation
Genes involved in Cancer Oncogenes Tumor Suppressor Genes
Oncogenes
Proto- oncogenes and oncogenes
Conversion of Proto-oncogenes into oncogenes
Tumor Suppressor Genes
Role of p53 in cancer
Retino Blastoma
Treatment of Cancer By Surgery Chemotherapy Radiation therapy Immunotherapy Gene therapy Inhibiting the activity of cancer promoting genes (Antisense approach) Inhibition of Angiogenesis