Bioprocessing and its significance

Bioprocessing and its significance

1. Bioprocessing and its significance

2. Definition of Bioprocessing A bioprocess can be explained as a particular process that utilises complete living cells or some of their cellular components to get wanted items.

3. Definition of Bioprocessing The process is used in the creation of nourishments, pharmaceuticals, flavours , energy and synthetic concoctions with the guide of a biocatalyst. A catalyst in bioprocessing can be microorganisms, plants or creature cells in a bioreactor.

4. Definition of Bioprocessing Alongside, it includes hereditary designing for the control of animals, plants and microorganisms. Downstream handling is required to expel debasements, mass volume decrease and concurrent convergence of the ideal item from the bioreactor.

5. Upstream and Downstream Process in Bioprocess Cell treatment bioprocessing is an order that combines the fields of cell treatment and bioprocessing. Cell treatment bioprocessing aims to build up reproducible and sturdy manufacturing procedures to produce remedial cells.

6. Upstream and Downstream Process in Bioprocess Commercially significant bioprocesses can: Generate items to keep up the entirety of the quality gauges of biopharmaceutical drugs It can also offer clinical and industrial measures of remedial cells all through different phases of improvement. Control the expense of merchandise ( CoGs ) of the last medication item.

7. Upstream Bioprocessing Bioprocessing hardware incorporates a wide range of gear for explicit capacities and applications. In extensive terms and as for a procedure stream graph, the hardware can be categorised in three categories: Upstream Downstream Support Upstream gear manages the development of a host life form to deliver a product. The product may be simply the living beings, it might be held inward to the creature, or it may be discharged into the development medium.

8. Downstream Bioprocessing Downstream bioprocessing explains the part from the upstream where the cell mass is handled to meet virtue and quality prerequisites. It is typically partitioned into three primary areas: cell interruption, a decontamination segment and a cleaning segment.

9. Downstream Bioprocessing The means of downstream preparing are: Insolubles are Removed Centrifugation Filtration Sedimentation Precipitation Electro-precipitation Flocculation Gravity settling

10. Downstream Bioprocessing The means of downstream preparing are: Product Isolation  Precipitation Adsorption Solvent extraction Ultrafiltration

11. Downstream Bioprocessing The means of downstream preparing are: Purification of Product size inclusion affinity ion-exchange chromatography reversed-phase chromatography crystallisation Reversed-phase chromatography

12. Downstream Bioprocessing The means of downstream preparing are: Polishing of the Product crystallization lyophilisation desiccation

13. Significance of Bioprocessing Bioprocess engineering is concerned with translating biological science into biologically based manufacturing.

14. Significance of Bioprocessing OPPORTUNITIES Biopharmaceuticals and Biopesticides from Insect Cell-Baculovirus System Baculovirus-Insect Expression System for Vaccine Production

15. Significance of Bioprocessing OPPORTUNITIES Gene-Based Pharmaceuticals and Gene Therapy

16. Significance of Bioprocessing OPPORTUNITIES Cell-Transplantation Therapy

17. Significance of Bioprocessing OPPORTUNITIES New Catalysts

18. Significance of Bioprocessing OPPORTUNITIES Cells, Organs, and Biomaterials

19. Significance of Bioprocessing OPPORTUNITIES Transgenic Animals

20. Significance of Bioprocessing OPPORTUNITIES Transgenic Plants

21. Significance of Bioprocessing OPPORTUNITIES Non-traditional Organisms Living at the Extremes: Extremophiles

22. Significance of Bioprocessing OPPORTUNITIES Energy and Renewable Resources

23. Significance of Bioprocessing OPPORTUNITIES Agricultural Chemicals and Food

24. Significance of Bioprocessing OPPORTUNITIES Plant-Cell Culture

25. Significance of Bioprocessing OPPORTUNITIES Plants and Seeds

26. Significance of Bioprocessing OPPORTUNITIES The Environment Many environmental problems will require bioprocess engineering. eg. - minimization of manufacturing waste, treatment of municipal waste, environmentally friendly manufacturing

27. Significance of Bioprocessing OPPORTUNITIES Space The unique problems presented by the manned exploration and colonization of space pose major and important challenges for bioprocess engineering.

28. Significance of Bioprocessing DEFENSE AND NATIONAL SECURITY Cleanup The Department of Defense (DOD) and Department of Energy face enormous problems in cleanup of military bases as they are closed or moth-balled and in cleanup of weapons laboratories. In the former, biological methods might play an important part.

29. Significance of Bioprocessing DEFENSE AND NATIONAL SECURITY Chemical and Biological Warfare A continuing problem in DOD concerns chemical and biological warfare. The stated U.S. position is to be prepared in a defensive mode, but not to be involved in production of biological weapons. The importance of either chemical or biological agents as practical weapons systems remains to be established.

30. Reference Book Chapter 6 The Future | Putting Biotechnology to Work: Bioprocess Engineering | The National Academies Press https://www.nap.edu/read/2052/chapter/8