Biosynthesis of Purines

biosynthesis of purine

1. Biosynthesis of P urine Varinder Khepar PhD Chemistry 1

2. Biosynthesis of Purine Biosynthesis is a multi-step, enzyme-catalyzed process where substrates are converted into more complex products in living organisms. In biosynthesis, simple compounds are modified, converted into other compounds, or joined together to form macromolecules. This process often consists of metabolic pathways. The purines are built upon a pre-existing ribose 5- phosphate. Liver is the major site for purine nucleotide synthesis. Erythrocytes & brain cannot produce purines . 2

3. Pathways There are Two pathways for the synthesis of nucleotides: 1. De-novo synthesis : Biochemical pathway where nucleotides are synthesized from new simple precursor molecules 2. Salvage pathway : Used to recover bases and nucleotides formed during the degradation of RNA and DNA. 3

4. Sources of different atoms of purine ring 4

5. Purine de novo synthesis 5

6. Phosphoribosyl pyrophosphate (PRPP) is inhibited by adenylate (AMP), inosylate (IMP), and guanylate (GMP), as indicated. 6

7. Guanosine monophosphate Adenosine monophosphate Inosine Monophosphate 7

8. Salvage Pathway 8

9. 9

10. Catabolism of Purine 10

11. 11

12. 12

13. 13

14. 14

15. Inhibitor Of Purine Biosynthesis 15

16. 16

17. http://www.sivabio.50webs.com/nucleicacid.htm Fasullo , M., & Endres , L. (2015).  Nucleotide Salvage Deficiencies, DNA Damage and Neurodegeneration . Int. J. Mol. Sci . , 16(12), 9431–9449.   doi:10.3390/ijms16059431.   https://byjus.com/biology/difference-between-purines-and-pyrimidines/ https://en.wikipedia.org/wiki/Purine 17

18. THANK YOU 18