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1. ZINC FERRITE SPIONS : SYNTHESIS AND ITS CHARACTERIZATION NAME: SANJANA ROY COLLEGE NAME: ANAND COLLEGE OF EDUCATION, DEPT. OF PHARMACY SUBJECT: PROJECT WORK SUBJECT CODE: PT883 ROLL NO: 36501920024 REGISTRATION NO: 203650201910040 CLASS: B.PHARM 4 TH YEAR 8 TH SEMESTER SESSION: 2020-2024

2. Contents INTRODUCTION SYNTHESIS CHARACTERIZATION RESULT AND DISCUSSION APPLICATIONS CONCLUSION REFERENCE

3. Introduction ZnFe 2 O 4 SPIONS

4. Synthesis F 5.33 gm ZnCl 2 added to distilled water in a beaker. Added to mixture of FeCl 3 + ZnCl 2 in a beaker Titration against 3M Naoh solution until the black precipitation was formed. Precipitation was preformed by distilled water was it Filter the product Dry the product by hot air oven or air dry Then dry product is collected make in to a powder from

5. Characterization XRD for determination of phase formation and particle size

6. Result & Discussion

7. Applications SPION APPLICATION TARGATED DRUG DELIVERY MRI CELL MAGNETIC LABELING Inflamation Stem cell tracking Anti infective Blood clot dissolving Magnetic Carrier Magnetic gene transmission Gene expression Radioactive Magnetic isolation

8. Conclusion We successfully prepared SPIONS by using the co-precipitation method and characterized them through XRD, FT-IR, and Magnetization. Zinc ferrite exhibits excellent biocompatibility, minimal toxicity, and more importantly, exciting magnetic properties. ZnFe2O4 Superparamagnetic iron oxide nanoparticles (SPIONS) have emerged as promising candidates in magnetic resonance imaging, biosensing, and drug delivery due to biocompatibility and superior magnetic susceptibility.

9. T.W. Odom, J.-L. Huang, P. Kim, C.M. Lieber, Atomic structure and electronic properties of single-walled carbon nanotubes, Nature 391 (1998) 62–64. Friedrich RP, Janko C, Unterweger H, Lyer S, Alexiou C. SPIONs and magnetic hybrid materials: Synthesis, toxicology and biomedical applications. Physical Sciences Reviews. 2023 Aug 1;8(8):1435-64. Upadhyay C, Verma HC, Sathe V, Pimpale AV. Effect of size and synthesis route on the magnetic properties of chemically prepared nanosize ZnFe2O4. Journal of Magnetism and Magnetic Materials. 2007 May 1;312(2):271-9. Khurshid R, Ali F, Afzal A, Ali Z, Qureshi MT. Polyol-mediated coprecipitation and aminosilane grafting of superparamagnetic, spinel ZnFe2O4 nanoparticles for room-temperature ethanol sensors. Journal of the Electrochemical Society. 2019 Mar 6;166(4):B258. Khanna L, Tripathi SK. Biomedical Applications of Superparamagnetic Nanoparticles–An Insight. InNanoBioEngineering 2018 Nov 2 (pp. 27-41). CRC Press. Reference

10. Thank You