Blood_coagulation(Blood clotting Chapter).pdf

Blood coagulation help in getting back to you 1st year admission test result published the year of medical sciences MADIKERI h nhi to nhi ho gya hai h nhi to nhi ho gya hai h nhi nhi hai h nhi nhi nhi h na to nhi h na bol do not have any other questions please let us know what you want to nhi ho sakta hai kya h hi nhi h na bol do you have to nhi h na to nhi ho rha hai kya kya hua hai h kya hai kya kya hua hai kya h ye UPI Id h nhi to nhi ho gya h tu bta kha tak h nhi to nhi ho sakta h kya hai kya h ye sab ready hai kya h ye sab ready ho to nhi ho gya h tu ja skta h nhi to nhi h

1. BY DEEPAK VERMA

2. COAGULATION OFBLOOD
Coagulationorclottingisdefinedastheprocessinwhich
bloodlossesitsfluidandbecomesa jellylikemassfew
minutesafteritisshedoutofcollectedinacontainer.

3. COAGULATION OFBLOOD
Duringthisprocess, thefibrinogenisconvertedintofibrin.
Fibrinthreadsgetattached totheloose plateletplug,
whichplugstherupturedpartofbloodvesselsand
preventsfurtherbloodlosscompletely.

5. FACTORSINVOLVEDINBLOODCLOTTING
CLOTTINGFACTORS
Coagulationofbloodoccursthroughaseriesofreactions
due to the activation of a group of substances necessary
forclotting arecalledclottingfactors.

6. FACTORSINVOLVEDINBLOODCLOTTING
Thirteenclottingfactorsareidentified.
1.Factor–1:Fibrinogen
2.Factor–II:Prothrombin
3.Factor–III:Thromboplastin(TissueFactor)
4.Factor–IV:Calcium
5.Factor–V:LabileFactor
6.Factor–VI:Presencehasnotbeenproved
7.Factor–VII: Stablefactor

7. FACTORSINVOLVEDINBLOODCLOTTING
Thirteenclottingfactorsareidentified.
8.Factor–VIII:Antihemophillicfactor(Antihemophillic
globulin)
9.Factor –IX:Christmas Factor
10.Factor–X:StuartProwerfactor
11.Factor–XI:PlasmaThromboplastinAntecedent
12.Factor–XII:Hageman factor(Contactfactor)
13.Factor–XIII:Fibrin stabilizingFactor(Fibrinase)

8. STEPS OFBLOODCLOTTING
Ingeneralbloodclottingoccursinthreestages.
1)Formation of Prothrombin activator
2)Conversion of prothrombin into thrombin
3)Conversionof fibrinogenintofibrin

9. 1.FORMATION OFPROTHROMB INACTIVATOR
Bloodclottingcommenceswiththeformationofa substance
Called prothrombin activator,whichconvertsprothrombininto
thrombin.
Itsformationisinitiatedbysubstanceseitherwithintheblood
oroutsidetheblood.
Thus,formationofprothrombinactivator occursthroughtwo
pathways:
1.Intrinsic
Pathway
2.Extrinsic
Pathway

11. INTRINSICPATHWAYFORTHEFORMATIONOF
PROTHROMBINACTIVATOR

12. EXTRINSICPATHWAYFORTHEFORMATION
OFPROTHROMBINACTIVATOR

15. 2.CONVERSIONOFPROTHROMBIN INTO
THROMBIN

16. 3.FIBRINOGENINTOFIBRIN

17. BLOODCLOTTINGDISORDERS
HEMOPHILIA
PURPURA
VONWILLEBRAND DISEASE

18. ANTICOAGULANTS

19. TESTSFORBLOODCLOTTING