bodiesindermatology-.pptx

explains in detail regarding different histopathological bodies in dermatology

1. Shumez .H. Bodies in Dermatology

2. Classification Normal cutaneous anatomy Glomus bodies, Lamellar bodies, Weibel palade bodies Hair disorders Arao Perkin bodies, Papillary mesenchymal bodies Granulomatous disorders Asteroid bodies, Schaumann bodies Papulosquamous disorders Civatte bodies, Corp ronds and grains

3. Metabolic & storage disorders Banana bodies, Caterpillar bodies, Farbers bodies, Lafora bodies, Zebra bodies, Alder Reilly bodies Tumors Dutcher bodies, psammoma bodies, Pustulo – ovoid bodies of Milian , Verocay bodies Histiocytic disorders Comma shaped bodies Benign pigmented lesions Kamino bodies

4. Collagen vascular disorders Cytoid bodies, LE Age related change Pertinax bodies Drug induced Heinz bodies Infectious disorders Dohle bodies, Mallory bodies, Michaelis – Gutmann bodies, Russell bodies, Donovan bodies, Cigar bodies, Medlar bodies, Guarnieri bodies, Henderson Patterson bodies, Cowdry A

5. Glomus bodies Specialized arterio venous shunts that connect an ateriole with a venule without the interposition of capillaries. Abundantly found in the pads and nail beds of fingers and toes. Concerned with temperature regulation.

6. Lamellar bodies A.k.a Odland bodies, Cementosomes . Round – oval granules that possess a highly ordered lamellar internal structure. Contain bipolar phospholipids, glycoproteins , and acid phosphatases . Measure 300 nm. Located in the cytoplasm of cells of upper spinous and granular layer.

7. Play an important role in barrier function and intercellular cohesion within stratum corneum . Abnormal formation and secretion of lamellar bodies seen in Harlequin Icthyosis .

8. Weibel – Palade bodies An electron dense cytoplasmic organelle. Measures 0.1 µ in diameter and 3 µ in length. Composed of a number of tubules arranged in the long axis of the rod. Endothelium specific inclusions. Contain Von Willebrand factor, P – selectin , and CD63.

9. Arao – Perkin bodies Begin as a small cluster of elastic fibers in the neck of the dermal papilla. They clump in the catagen . With progressive shortening of the anagen in AGA, multiple elastic clumps may be found in the stellae , like rungs of a ladder.

10. Papillary Mesenchymal bodies Constitute clusters of fibroblasts adjacent to epithelial buds as in the germinative portion of the normal hair papilla. Observed in trichoepitheliomas .

11. Asteroid bodies Star shaped eosinophilic structures with a centre that is brown red and radiating blue spikes within histiocytes or multinucleated giant cells. Measure 10 – 15 µ in size. Contain collagen showing 64 – 70 nm periodicity. ( collagen trapped in epitheliod cells ) Seen in Sarcoidosis , Sporotrichosis , and Actinic granuloma .

12. Schaumann bodies A.k.a. Conchoidal bodies. Basophilic concentric lamellar structures Measure 100 µ in size. Composed of lipomucoglycoproteins impregnated with calcium and iron. Show central birefringent crystals. Seen in Sarcoidosis , Tuberculosis.

13. Banana bodies Cresentic shaped bodies within Schwann cells. Seen in disseminated lipogranulomatosis .

14. Caterpillar bodies Epidermal eosinophilic bodies that are elongated and sometimes segmented. Ultrastructurally , they have cellular organelles, colloid and electron dense material. They form the roof of the blister in Porphyria Cutanea Tarda .

15. Farber’s bodies Curvilinear bodies within cytoplasm of fibroblasts and occasionally of endothelial cells. Also found within phagosomes of histiocytes at various stages of degradation. Seen in Farber’s disease.

16. Lafora bodies A.k.a. Polyglucosan bodies Bodies seen in the excretory ducts of eccrine and apocrine sweat ducts of clinically normal skin. Seen in Lafora disease - dementia, myoclonus , seizures, rarely skin lesions.

17. Zebra bodies Vacuoles with transerve membranes within endothelial cells. Seen in Farber’s disease and various other ganglioside storage disorders.

18. Alder Reilly bodies Deeply basophilic granules seen within neutrophils and sometimes within lymphocytes and monocytes . Contain incompletely degraded mucopolysaccharides . Seen in mucopolysaccharide storage disorders like Hunter’s syndrome, Hurler’s syndrome

19. Dutcher bodies Eosinophilic intranuclear pseudo inclusions within plasma cells. Formed by a cytoplasmic invagination into the nucleus. They are smooth, membrane bound and surrounded by clumped chromatin. Seen in Lymphoplasmacytic lymphoma, Mucosa associated lymphoid tissue (MALT), myeloma, Waldenstrom Macroglobulinemia .

20. Psammoma bodies Concentrically laminated, hyalinized or calcified basophilic structures. Seen in cutaneous meningioma .

21. Pustulo – Ovoid bodies of Milian Large eosinophilic intracytoplasmic granules surrounded by a clear halo. Seen in granular cell tumour of tongue.

22. Verocay bodies Two neighbouring palisades, intervening cytoplasm of schwann cells and associated reticular fibers all in combination constitute a verocay body. Seen in Schwannomas .

23. Civatte bodies A.k.a. Colloid, Cytoid , Hyaline, Sabaroud bodies. Necrotic keratinocytes measuring 20 µ in diameter and possessing a homogenous eosinophilic appearance. Located in the lower epidermis, especially in the papillary dermis. Seen in GVHD, Lichen planus , Lichen nitidus , drug reactions, Lupus erythematosus , Lichenoid actinic keratoses , and even normal skin.

24. Corp Ronds and Grains Dyskeratotic cells found as solitary or small groups of separated cells in the upper malpigian layer and stratum corneum . Small pyknotic nucleus, clear perinuclear halo and brightly eosinophilic cytoplasm. Grains are small cells with elongated nuclei and scanty cytoplasm in upper layers of epidermis. Seen in Darier’s disease.

25. Comma shaped bodies Seen within histiocytes . Formed by two electron dense membranes of 6 nm, separated by a light space of 8 nm. Seen in Juvenile xanthogranulomas , benign cephalic histiocytosis , sinus histiocytosis .

26. Kamino bodies Eosinophilic globules seen in basal layer above the tips of dermal papilla. Found in Spitz nevi, melanomas and other nevi.

27. Cytoid bodies Localized areas of swelling in the inner layers of retina, predominantly involving the nerve fibre layer. Confined to the posterior fundus . Contain giant globular bodies with round or oval eosinophilic inclusions. Fundal Cytoid bodies seen in SLE, dermatomyositis , PAN, scleroderma and giant cell arteritis .

28. LE bodies Following the nuclear penetration of traumatised leucocytes by the LE cell factor, the altered nucleus detaches itself from the cytoplasm and appears as a free extracellular LE body. Appears as homogenous, pale blue to deep purple material pushing the nucleus of the phagocyte to one side of the cell. Seen in SLE.

29. Pertinax bodies Acidophilic masses which represent remnants of keratinocyte nuclei. Seen in senile nails.

30. Heinz bodies Blue inclusions within RBCs composed of denatured haemoglobin . Appear as single or multiple inclusions of 2 µ in diameter and often appear attached to the membrane. Seen in drug reactions to dapsone , chloroquine , etc.

31. Dohle bodies Small, basophilic, rounded – oval or rod shaped bodies chiefly in the periphery of polymorphonuclear leucocytes Seen in scarlet fever.

32. Mallory bodies Located intranuclearly within epidermal cells or lay within lymph spaces. Made up of a delicate reticulum which stains light blue and the surrounding protoplasm pink. Seen in measles and scarlet fever.

33. Michaelis – Gutmann bodies Ovoid – round basophilic inclusions that vary in size from 5 -15 µ and are seen in granular Von Hansemann histiocytes . They are either homogenous or have a target appearance by showing concentric laminations. Seen in Malakoplakia .

34. Russell bodies Homogenous, elliptical, intracytoplasmic eosinophilic inclusions seen within plasma cells. 20 – 40 µ in diameter. Seen in Rhinoscleroma .

35. Cigar bodies At 37 ˚ C, Sporothrix schenckii may be present in the tissue as a yeast like form 2 - 8 µ in diameter or as elongated cigar bodies 4 - 10 µ in length. Seen in Sporotrichosis .

36. Medlar bodies A.k.a. Sclerotic bodies, Muriform cells, Copper pennies. Dark brown, thick walled, ovoid or spherical spores varying in size from 6 – 12 µ, lying singly, in clusters or in chains within histiocytes in microabscesses as well as free within the tissue. Seen in Chromomycosis .

37. Leishman Donovan bodies The cytoplasm of histiocytes is filled with numerous dull blue – grey, round to oval bodies that exhibit a round basophilic nucleus and a rod shaped paranuclear kinetoplast . Measure about 2 – 4 µ in diameter. Seen in Leishmaniasis .

38. Guarnieri bodies A.k.a. Paschen bodies. Intracytoplasmic eosinophilic aggregation of virus particles. Seen in Variola , Vaccinia , Human cowpox, Parapox .

39. Henderson – Patterson bodies Ovoid, eosinophilic structures in the lower cells of the stratum malpighii . They increase in size as the infected cells move towards the surface. In the upper layers of the epidermis, the molluscum body compresses the nucleus of the cell so that it appears as a thin crescent at the periphery of the cell. Seen in Molluscum contagiosum .

40. Cowdry A bodies A.k.a. Lipschutz inclusions. Intranuclear eosinophilic inclusions surrounded by a clear halo. Measure 3 – 8 µ in diameter. Seen in herpes simplex and Varicella Zoster lesions.

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