Definition and causes of BRONCHITIS
Definition
This is an inflammation of the bronchi associated with
excessive sputum production and a barking cough
Causes
Viral causes
Influenza
Rhino virus
Corona virus
Adeno virus
Respiratory syncytial virus (RSV)
Risk factors of BRONCHITIS
Cigarette smoking
Viral infections of RT
Chronic obstructive pulmonary diseases, COPD e.g asthma
and Emphysema
Prolonged exposure to coldness
Exposure to heavy amounts of second hand smoke and
pollution
Frequent use of cooking fire without proper ventilation
Prolonged exposure to dust and smoke
Whooping cough
Pathophysiology of BRONCHITIS
Chronic smoking destroys the cilia in RT lining
Mucus in lower lungs stagnates there as it cant be brought
by cilia to Carinii junction (where trachea bifurcates into
two bronchi).
At this jxn there is high nerve endings which will stimulate
a cough reflex & in this case it won’t be initiated.
Mucus plugging will favor bacterial invasion destroying
lung tissue & capillaries.
Forceful coughing leads to rapture of capillaries leading to
haemoptysis.
Pathophysiology cont’d
Increased number (hyperplasia) and increased size
(hypertrophy) of goblet cells & mucus glands in the air way.
Increased mucus produced >narrowing of the airway
causing a barking cough and excessive sputum production.
Inflammation is followed by scarring and remodeling the
thickness of the walls>further narrowing=fibrosis of lung
tissue.
Emphysema=lung damage &inflammation of air sacs
(alveoli) or enlargement of the air sacs distal to terminal
bronchioles with destruction of their walls.
Classification of BRONCHITIS
Acute Bronchitis-sudden inflammation of bronchi
Usually viral but may be complicated by bacterial infections
especially in smokers and in patients with COPD/asthma.
Commonly mild but can become severe in
immunosuppressed patients and those with chronic lung or
heart diseases.
Infants usually get bronchiolitis (inflammation of
bronchioles) causing symptoms similar to asthma.
Classification of BRONCHITIS cont’d
Chronic Bronchitis
This chronic inflammation of bronchi characterized
by excessive sputum production with cough present
on most days for at least 3 months in a year with
positive history of smoking.
It is not primarily an infective condition but acute
exacerbations or can become worse by viral and
bacterial infections
Signs and symptoms of BRONCHITIS
Dry cough followed by a productive cough with a lot of
mucus production/sputum (>3/12)
Wheezing with occasional crackles/crepitations
Muscle aches/weakness/fatigue
Chest tightness/chest pain
Shortness of breath/dysponea
Fever with chills
History of cigarrette smoking for a long time
D.DX OF BRONCHITIS
Asthma
Emphysema
PTB
Whooping cough (Pertusis)
Laryngotracheobronchitis(LTB/croup)
Investigations
Chest X-ray
Pulmonary function test (spirometry)
ZN staining
Gram staining
FBC/CBC and C/S of Sputum
Chest CT scan
MANAGEMENT OF BRONCHITIS
Supportive Mgt
•Viral bronchitis only symptomatic RX is needed
•Bed rest until a febrile
•Fluid intake to maintain hydration and facilitate
expectoration
•Cough expectorants e.g Zedex, Brozedex, Zecuff, Deleased,
Lubyamira, Kisakyamuzade, Kabuuti etc
•Steam inhalation/warm moist air to facilitate expectoration
•Stopping smoking, Steroids
•Analgesics e.g paracetamol, ASA, Ibuprofen etc.
MGT OF BRONCHITIS cont’d
Drug mgt=Chronic bronchitis or if high temp persist or mucus
becomes prulent in acute bronchitis.
•Caps Amoxicillin 500mg tds for 7-10days
•Tabs Co-Amoxiclav 625mg bd for 7days
•Tabs Erythromycin 500mg qid for 7 days
•Tabs Azithromycin 500mg od for 5days
•Tabs Cefuroxime 250mg bd for 7 days
•Caps Doxycycline 100mg bd for 7 days
•Tabs Clarithromycin 250mg-500mg bd for 7 days
•Other antibiotics can also RX Bronchitis (IM/IV)