calibration of dissolution apparatus[1].pptx

calibration importance, calibrtation parameters, limits, procedures are included in the presentation

1. Aim : To Perform Calibration of Dissolution Apparatus. ( MPH105P ) By Harshid Kukadiya M.Pharm ( sem I) Guided by Ms. Manasi Athlye Asistant professor Department of pharmaceutics L. M. College of Pharmacy, Navarangpura , Ahmedabad.

2. Contents : Requirements Definition Objectives Advantages Procedure

3. Requirements Apparatus Butter paper & spatula Volumetric flasks Pipette Beaker Funnel & filter paper Instruments Dissolution apparatus Analytical weigh balance Tachometer Thermometer Stop watch Wobble meter Depth gauge tester Vernier callipers Chemicals & reagents Prednisolone tablets Distilled water

4. Calibration Calibration is the process of adjusting an instrument or equipment to meet the manufacture’s specification. Calibration is a process by which ensure that an instruments readings are accurate with reference to established standards. The measuring devices require calibration.

5. Different type of dissolution apparatus

6. Dissolution apparatus Parameters that should be calibrated

7. RPM calibration Range : 30 to 100 Acceptance criteria : 4 % Temperature calibration Range : 30 to 40 o C Acceptance criteria : 0.5 C Calibration of time Acceptance criteria : NMT 30 sec ( Tachometer ) ( Thermometer ) ( Stopwatch )

8. Wobbling check Acceptance criteria : NMT 1 mm Distance Acceptance criteria : NMT 2 mm from 25 mm Jar centering Acceptance criteria : NMT 2 mm ( Wobble meter ) ( Depth gauge tester ) ( Vernier calipers )

9. Calibrator tablets Calibrator tablet : Prednisolone Dissolution criteria Temperature : 37 +_ 0.5 C Medium : 500 ml water Time : 30 minutes RPM : 50 Apparatus : Basket

10. Thank you..