Calpol Tablets (Paracetamol or Acetaminophen)

Calpol (Paracetamol Tablets also known as Acetaminophen or APAP) is used for the fast effective temporary relief of pain and discomfort associated with Headache, Muscular aches, Period pain, Arthritis / Osteoarthritis, Toothache, Migraine, Colds and flu, Tension headache, Sinus pain/headache and Backache.
Calpol tablets are also used to reduce fever.

1. Calpol Tablets
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Calpol (Paracetamol Tablets also known as
Acetaminophen or APAP) is used for the fast effective
temporary relief of pain and discomfort associated with
Headache, Muscular aches, Period pain, Arthritis /
Osteoarthritis, Toothache, Migraine, Colds and flu,
Tension headache, Sinus pain/headache and
Backache.
Calpol tablets are also used to reduce fever.

2. Calpol Tablets
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Calpol (Paracetamol Tablets) are
manufactured by GlaxoSmithKline
Pharmaceuticals Limited
(Website: www.gsk-india.com)

3. Paracetamol Tablets – Brand Names
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Paracetamol tablets also known as
Acetaminophen or APAP, are
available as Panadol, Calpol, Crocin,
Cofamol, Ultragin, Algina, Almol
Forte, Biocetamol-500, Biocetamol-
650, Febrex, Febrinil, Nicetamol,
Parafizz, Temfix.

4. Active Ingredient
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The active ingredient contained in Calpol
tablets is Paracetamol (also known as
Acetaminophen or APAP).
Each Calpol tablet contains 500 mg or 650 mg
of Paracetamol respectively.

5. Chemical Structure
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The structure of Paracetamol (also known as
Acetaminophen or APAP) is given below:

6. Uses of Calpol Tablets
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Calpol tablets, manufactured by
GlaxoSmithKline Pharmaceuticals Limited,
India is a medication used to treat pain and
fever.
Paracetamol (also known as Acetaminophen
or APAP) temporarily relieves minor aches
and pains due to: minor pain of arthritis,
muscular aches, backache , premenstrual
and menstrual cramps, the common cold,
headache, toothache, temporarily reduces
fever

7. Calpol (Paracetamol Tablets) Dosage

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➢Adults and Children 12 years and over:
Take 1 tablet every 3 to 4 hours or 2 tablets
every 6 hours while symptoms last.
➢Do not take more than 6 tablets (more
than 3,000 mg of Acetaminophen) in any 24
hour period.
The dosage of Calpol tablets (Paracetamol 500 mg
also known as Acetaminophen or APAP) is given
below:

8. Calpol 650 mg Tablets Dosage

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➢ Adults (above 18 years old): Take 2
tablets every 8 hours with water. Swallow
whole; do not crush, chew, split or dissolve
➢Do not take more than 6 tablets in any 24
hours period. Do not use for more than 10
days unless directed by a doctor
➢Patients under 18 years of age: Ask a
doctor
The dosage of Calpol tablets (Acetaminophen or
APAP) is given below:

9. Storage Instructions

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Calpol tablets (Paracetamol also known
as Acetaminophen or APAP) have to be
stored at controlled room temperature
i.e. from 20°C to 25°C (68°F to 77°F)
with excursions permitted between 15°
to 30°C (59° to 86°F).
Keep this as well as all other medicines
away from children and pets.

10. Warnings

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Severe liver damage may occur if you take
more than 4,000 mg of Acetaminophen in 24
hours which is the maximum daily amount
Do not use Calpol with other drugs
containing Acetaminophen
Do not consume 3 or more alcoholic drinks
every day while using Calpol (Paracetamol
tablets)
Patients should contact their doctor if
symptoms persist (if the pain lasts for more
than 10 days, if there is redness or fever lasts
more than 3 days).

11. Calpol Tablets
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Contraindications
Calpol is contraindicated in patients
with a hypersensitivity to Paracetamol
(also known as Acetaminophen or
APAP) or any other component of
this medication.

12. Calpol Side Effects
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➢Calpol (Acetaminophen or APAP)
side effects are rare and usually
mild, although haematological
reactions have been reported. Skin
rashes and other hypersensitivity
reactions occur occasionally

13. Calpol Overdose
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Toxic symptoms of Calpol (Paracetamol Tablets)
overdose include vomiting, abdominal pain,
hypotension and sweating.
The most serious adverse effect of acute
overdose of Paracetamol is a dose-
dependent, potentially fatal hepatic necrosis.
Clinical and laboratory evidence of
hepatoxicity may be delayed for up to one
week.
Major manifestations of liver failure such as
jaundice, hypoglycemia and metabolic acidosis
may take at least 3 days to develop.

14. Acetaminophen Overdose
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In cases of overdose, methods of reducing the absorption
of Calpol (Acetaminophen) are important. Gastric lavage
is necessary even if several hours have elapsed.
Prompt administration of 50 gms activated charcoal
and 500ml iced mannitol 20% by mouth, may reduce
absorption.
If the history suggests that 15 grams Paracetamol or
more has been ingested, administer one of the following
antidotes:
Acetylcysteine 20% i.v.: Administer intravenously, 20%
Acetlcysteine immediately without waiting for positive
urine test or plasma level results: initial dose of 150mg/kg
over 15 minutes, followed by continuous infusion of
50mg/kg in 500ml 5% glucose/dextrose over 4 hours
and 100mg/kg in 1L 5% glucose/dextrose over 16 hours;

15. Calpol Overdose
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OR
Oral Methionine: 2.5 grams immediately
followed by three further doses of 2.5g at
four hourly intervals. For a 3 year old child, 1g
Methionine every four hours for four doses has
been used;
OR
Oral Acetylcysteine 5%: 140mg/kg as a
loading dose, then 70mg/kg every 4 hours for
a total of 17 maintenance doses.
If more than ten hours have elapsed since the
overdosage was taken, the antidote may be in
ineffective

16. Acetaminophen During Pregnancy
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Paracetamol (Acetaminophen tablets) has
been classified by the US FDA as
Pregnancy Category C.
In pregnant rats receiving oral medicine at
doses up to 0.85 times maximum human
daily dose (MHDD) during organogenesis,
fetotoxicity and dose-related increases in
bone variations (reduced ossification and
rudimentary rib changes) were observed.
Use during pregnancy should be avoided
unless advised by a doctor.

17. Calpol Tablets
For more details on
Calpol Tablets click here
© Clearsky Pharmacy
Calpol (Paracetamol tablets) by
GlaxoSmithKline Pharmaceuticals Limited, India.