Carcinoma BREAST : updates dr quiyum.pptx

carcinoma breast details

1. Carcinoma Breast DR MD Abdul Quiyum resident surgeon 300 Bedded Hospital,Narayanganj

2. Objectives What is Breast Cancer Types of Breast Cancer Etiology of Breast Cancer Risk factors Signs and Symptoms Investigations Treatment Prevention Screening

3. Relevant Anatomy

4. Etiopathogenesis Two major factors Hormonal factors Hormone dependent disease Excess endogenous Estrogen, Prolong use of exogenous Estrogen(HRT) Genetic factors 10% Breast cancer found to have inherited mutation BRCA gene

5. BRCA BRCA1 DNA  repair gene Implicated in both Breast & Ovary BRCA 1 del.is seen in two third of women with inherited breast cancer BRCA2 DNA Repair gene Del.is seen in one third cases of CA breast and ovary in female and Prostate in male

6. P53 gene Tumor suppressor gene Mutation of P53 Gene Acquired defect accounts 40% cases of sporadic breast cancer Rarely in women with family history of breast cancer

7. Risk Factor

8. Mode of spread

9. Breast cancer Classification Based on Tissue Types Noninvasive(In situ) carcinoma Invasive carcinoma Paget's disease of Nipple

10. Presentation

11. Breast Examination Technique

12. Diagnostic Tools

13. Mammography imaging: Left, craniocaudal view. Right, mediolateral oblique view.

14. Digital breast tomosynthesis (DBT), is a modified or advanced method of mammography which creates a stacked image due to its multiple projections from various angles, ranging from 15° (narrow range) to 60° (wide range) in relation to the chest wall.

15. USG Irregular shaped mass with ill-defined margins on US imaging

16. MRI of Breast

17. Type of Breast Biopsy FNA  Biopsy Core Needle Biopsy Sterotactic Biopsy. Wire Localization Biopsy Surgical Biopsy

18. Staging

19. Treatment Modalities Surgery Radiation Therapy Chemotherapy Hormonal Therapy

20. Surgical option Lumpectomy Radical Mastectomy(Rare) Modified Radical Mastectomy

21. Breast conserving surgery

22. Mastectomy

23. Common post operative Complication Common post operative complication

24. Neo adjuvant Or Adjuvant therapy

25. Receptor Status

26. Targeted Therapy

27. Survival

28. How to prevent

29. New concept of Breast reconstruction

30. Tracer placement