Biliary stone diseases
Mathew Philip
PVS Memorial hospital
Kochi
Prevalence of gallstones by age
and gender
Introduction
Eleven to 21% of cholelithiasis have
concomitant CBDS at the time of surgery
Majority of CBDS form in GB and then
migrate CBD
Pass into the duodenum following the bile
flow
May remain in the choledochus owing to
the smaller diameter at the Vater papilla
CBD stones - Endotherapy
Diagnosis
US,MRCP, EUS and ERC
Endoscopic retrograde cholangiography
(ERC) changed the approach to CBDS
Role of EUS
Diagnosis of CBDS
Comparable to MRC
More sensitive for
Biliary microcalculi
Small stone impaction at ampulla
Biliary sludge
Reduce ERC interventions
Outline
Standard treatment of CBD stones
Define Difficult Bile duct stone
Factors associated with difficult CBD stones
Treatment strategies of difficult CBD stones
Outline
Standard treatment of CBD stones
Define Difficult Bile duct stone
Factors associated with difficult CBD stones
Treatment strategies of difficult CBD stones
Standard treatment of CBD stnes
Standard Treatment of
CBD stones
Outline
Standard treatment of CBD stones
Define Difficult Bile duct stone
Factors associated with difficult CBD stones
Treatment strategies of difficult CBD stones
Difficult CBD Stone
Commonly refers to a stone > 15 mm in diameter
Usually unable to make ES larger than 15 mm
Stones < 15 mm may be considered difficult if:
Proximal to stricture
Narrow intrapancreatic segment
Impacted
Multiple
Intrahepatic
Billroth II reconstruction
ES length is limited – e.g., periampullary diverticulum
Outline
Standard treatment of CBD stones
Define Difficult Bile duct stone
Factors associated with difficult CBD stones
Treatment strategies of difficult CBD stones
The variables affecting the success of stone
extraction
Stone size and shape
Bile duct diameter
Bile duct geometry
Composition of the stone
Bile duct strictures distal to the stone
Endoscopic technical difficulty of
CBD Stones
Older age (>65 years)
Previous gastrojejunostomy
Larger CBD stone (≥ 15 mm)
Impacted CBD stone
Use of mechanical lithotripsy
Short length of the distal CBD arm (<36mm)
Acute distal CBD angulation (<135 degrees)
Relative narrowing of distal CBD
GIE 2007; 66:1154-60
Reasons for unsuccessful
CBD stone removal
Anatomic obstacles to cannulation
Postoperative states
Billroth II gastroenterostomy
Roux-en-Y anastomosis
Anastamotic strictures
Ampullary or duodenal tumor mass
Scared duodenum from prior PUD
Periampullary diverticulum
Ampullary edema or inflammation
Outline
Standard treatment of CBD stones
Define Difficult Bile duct stone
Factors associated with difficult CBD stones
Treatment strategies of difficult CBD stones
Principle for treatment
Difficult biliary stone
Decrease stone size
Larger CBD orifice
Principle for treatment
Difficult biliary stone
Decrease stone size
Larger CBD orifice
Endoscopic Management of
Large Bile Duct Stones
Mechanical lithotripsy
Intraductal shockwave lithotripsy
Electrohydraulic
Laser
Extracorporeal shockwave lithotripsy
Dissolution
MTBE
Monooctanoin
Long term stents
Endoscopic Management of
Large Bile Duct Stones
Mechanical lithotripsy
Intraductal shockwave lithotripsy
Electrohydraulic
Laser
Extracorporeal shockwave lithotripsy
Dissolution
MTBE
Monooctanoin
Long term stents
Mechanical lithotripsy
Integrated
Salvage
Mechanical Lithotripsy
Advantages
Relatively easy to use
Relatively low cost
Prevents stone impaction
Can be done at initial ERCP
Disadvantages
Requires stone capture
Very hard stones may not fragment
Several baskets may be required for each patient
Soehendra Mechanical Lithotriptor
Mechanical lithotripsy- Salvage
Principle for treatment
Difficult biliary stone
Decrease stone size
Larger CBD orifice
Large Balloon
Dilatation of Sphincter
Bile Duct Stones
Failed Mechanical Lithotripsy
ESWL
Percutaneously Surgery
Cholangioscope
- Laser
- EHL
Stent
Dissolve
Cholangioscope
Mother baby scope
Two operators
Fargile
High repair costs
No dedicated irrigation channel
Limited two way steering
capability
Spyglass
Single operator
Four way steering capability
Independent irrigation channel
Diagnostic and therapeutic
capabiities
Mother-Baby Scope System
Spyglass
Spyglass
10 Fr catheter
Guidewire
Optical fiber
Direction
dials +
locks
Irrigation port
Conclusions
Biliary lithiasis affects 10% to 20% of
general population
CBDS in up to 20%
Endoscopic removal successful in 80-90%
using standard techniques
EUS has an important role and avoids
unnecessary ERC
Conclusions
Stone location, stone size, and bile duct
features may render stones non
extractable using standard retrieval
techniques
Balloon sphincteroplasty helps in
extracting bigger stone
Difficult stones mechanical lithotripsy is
easiest and cheapest, if stone can be
captured in basket
Conclusions
Using all endoscopic and ancillary
techniques, stone clearance rate ~ 97%
Direct cholangioscopic stone removal
could achieve near complete stone
removal except in intra hepatic stones
CBDS management is multidisciplinary
Tailored on available resources and
expertise