Chemical regulation of respiration

Central and peripheral chemoreceptors mechanism in response to hypoxia, hypercapnea and increased H+ ion concentration.

1. Chemical regulation of
respiration(physiology)

2. Chemical regulation
uDone by chemoreceptors
uRespond tohypoxia,
hypercapnia,increasedHion
conc
uAre of 2 types
uCentral andperipheral

4. CENTRAL
CHEMORECEPTORS
uSituation=DEEPER PARTS OF
MEDULLA
uClose toDRGneurons
uCHEMOSENSITIVE AREA (behind BBB)
uSensitive toincreasein H+ ions
uH+ IONS CANNOT CROSS

6. CENTRAL
CHEMORECEPTORS
uDetect CO2 changes
uCO2dependentrespiratory
regulation
uSensitive to CO2 in blood
uDirectly stimulated by H+ in CSF

7. INCREASE IN CO2 AND H+
only CO2 can cross BBB
CO2 reacts with water
CARBONIC ANHYDRASE
forms carbonic acid

8. Splits into H+ and HCO3-
H+ ions stimulate the central chemoreceptors
BBB
CO2,H+
BLOOD VESSEL
CO2+H2O
H2CO3H++HCO3-
Central chemoreceptors
surrounded by CSF
activate

13. Peripheral
chemoreceptors
uStimulus+ hypoxia
uOxygen sensors incarotid
andaortic bodies; glomus
cells
u3-5mmsize