Chf pharmacology of digitalis

chronic heart failure- pharmacology of digitalis

1. CHF-pharmacology of digitalis Submitted to- : Ms Seema Thakur Submitted by- : Navneet Singh Bpharm 6 th sem 1438002

2. Index Digitalis Pharmacology CHF Uses Contraindication Reference Thank you

3. Digitalis It is obtained from the leaves of Digitalis purpurea from family Scrophulariaceae

4. Pharmacology Action on heart-: Effect on the conducting tissues Coronary flow Positive Ionotropic action Enhances myocardial activity

5. Extra cardiac effect of digitalis-: GIT-:there may be nausea and vomiting due to trigger of CTZ zone Kidney-: increase in renal blood flow due to improved circulation and decreae in sympathetic activity CNS-: visual disturbances and disturbance of coloured vision may occur

6. Congestive heart failure CHF occur when cardiac output is sufficient to meet the demands of tissue perfusion. Heart failure may be primarily due to systolic or diastolic dysfunction. Systolic dysfunction: dilated ventricles and unable to develop sufficient wall tension – myocarditis , ischemic heart disease etc Diastolic dysfunction: Thickened wall, filling is impaired and low output – prolonged hypertension, hypertrophic myopathy etc Long standing CHF patients have both the types of dysfunctions

7. Congestive heart failure Digitalis induced enhancement of contractility increases the ventricular ejection and shift the curve relating stroke output to filling pressure towards normal so adequate output is obtained that does not produce CHF. Stroke Volume Preload (filling pressure) Normal Digitalis CHF

8. Therapeutic Uses Congestive heart failure Cardiac arrhythmia

9. Contraindication Tachycardia Hypokalemia Myocardial infarction Foetal toxicity

10. Reference KD tripathi “Essentials of Medical Pharmacology “ seventh edition pg no 512-519