Chloroquine

pharmacy

1. Pharmacology IV Topic : Anti Malarial Drug Chloroquine 1

2. C ontents Classification Pharmacokinetics Biochemistry of plasmodium Mechanism of action of chloroquine Pharmacological actions Adverse effects Uses and contraindications 2

3. Chloroquine Synthesized at  Bayer laboratories , and named as " Resochin “ Classification : Chemically 4-aminoquinoline Therapeutically As Supressive prophylactic and in Clinical cure ( erythrocytic schizonticide ) Gametocidal for p.vivax (prevent transmission) 3 Life cycle of Plasmodium (Cause of Malaria)

4. Pharmacokinetics : 4

5. Biochemistry of Plasmodium : 5

6. Mechanism of action

7. Pharmacological activity Antimalarial action : Active against erythrocytic vivax , malariae , ovale ,sensitive falciparum and gametocytes of vivax . Infections : Amoebic liver abcesses , Giardiasis , taeniasis Organ system effect : Depress myocardium Anti inflammatory Vascular smooth muscle relaxant

8. Adverse Effects : 8

9. Uses Malaria Giardiasis Infectious mononeucleosis Amoebic liver abcess Rheumatoid arthritis Contraindications and cautions Myopathy Visual abnormalities Phorphyria Hematologic disorders 9

10. References Goodman and Gillman’s Manual of Pharmacology and therapeutics Basic and Clinical Pharmacology Katzung by Betram G.Katzung , Susan B.Masters,Anthony J.Trevor Lippincott 10

11. Thankyou 11