classification of GBS helps in proper prognostication

Clinical diagnosis of GBS is important. By knowing the different presentations of GBS, the diagnosis is not missed

1. Classification of Guillain Barre Syndrome

2. Classification 1. Acute Inflammatory Demyelinating Polyneuropathy (AIDP) Commonest Prevalent in western countries Adults are affected more than the children Auto immune response against the Schwann cell and axons remains intact Ascending paralysis Recovery is rapid as remyelination occurs

3. 2. Miller Fisher Syndrome (MFS) Rare variant Adults ,young subjects and children are affected Involves PNS & CNS structures Pathological features resemble that of AIDP

4. 2. Miller Fisher Syndrome (MFS) Manifest as a descending paralysis Characterized by rapidly evolving triad of Ataxia ( mostly in gait and trunk) Ophthalmoplegia Areflexia Recovery can be rapid

5. 3.Acute Motor Axonal Neuropathy (AMAN) Also known as Chinese paralytic syndrome Prevalent in China & Mexico Children and young subjects are affected more than adults Autoimmune attack directed against the axon & Nodes of Ranvier Recovery takes place when axon regeneration is complete and it is rapid when lesion is localized

6. 4.Acute Motor Sensory Axonal Neuropathy (AMSAN) Closely related to AMAN Very rare Adults are mostly affected Affect the sensory with severe axonal damage Recovery is slow and often incomplete

7. 5.Acute Panautonomic Neuropathy Rarest variant of GBS, sometimes accompanied by encephalopathy Initial nonspecific symptoms of lethargy, fatigue, headache, and decreased initiative are followed by autonomic symptoms including orthostatic lightheadedness, blurring of vision, abdominal pain, alternating diarrhea & constipation, dryness of eyes, and disturbed micturition

8. 6.Bickerstaff's brainstem encephalitis (BBE) It is characterized by acute onset of ophthalmoplegia, ataxia, disturbance of consciousness & hyperreflexia.