click chemistry basic concepts and applications

about the noble prize winners

1. Click Chemistry: An Introduction, Exploring the Basics and Applications BY A.RESHMADEVI, I- M. Sc CHEMISTRY, SEETHALAKSHMI RAMASWAMI COLLEGE, TIRUCHIRAPALLI-620 002

2. What is Click Chemistry? Click Chemistry is a modular, reliable, and efficient approach to organic synthesis. It involves the use of simple, robust, and high-yielding chemical reactions to form covalent bonds between molecules. Key Characteristics of Click Chemistry: 1. High Efficiency: Click reactions are designed to be highly efficient, with high yields and minimal byproducts. 2. Selectivity: Click reactions are highly selective, with minimal side reactions. 3. Reliability: Click reactions are reliable, with consistent results under a range of conditions. 4. Simplicity: Click reactions are simple to perform, with minimal steps and reagents.

3. Click Chemistry Synthesis A copper-catalyzed reaction between an alkyne and an azide to form a triazole .

4. Types of Click Reactions: 1. Huisgen Cycloaddition: A copper-catalyzed reaction between an alkyne and an azide to form a triazole . 2. Thiol- Ene Reaction: A radical-mediated reaction between a thiol and an alkene to form a thioether . 3. Diels-Alder Reaction: A [4+2] cycloaddition reaction between a diene and a dienophile to form a cyclohexene.

5. Applications of Click Chemistry: 1. Pharmaceuticals: Click chemistry has been used to develop new pharmaceuticals, such as anticancer agents and antibiotics. 2. Materials Science: Click chemistry has been used to develop new materials, such as polymers and nanoparticles. 3. Biomolecular Engineering: Click chemistry has been used to develop new biomolecules, such as proteins and nucleic acids.

6. Advantages of Click Chemistry: 1. High Efficiency: Click chemistry reactions are highly efficient, often proceeding in high yield and with minimal side products. 2 . High Selectivity: Click chemistry reactions are highly selective, allowing for the formation of specific covalent bonds between molecules. 3. Mild Conditions: Click chemistry reactions are often performed under mild conditions, such as room temperature and atmospheric pressure. 4. Simple Reaction Conditions: Click chemistry reactions typically require simple reaction conditions, such as the absence of catalysts or the use of aqueous solvents.

7. Limitations of Click Chemistry: 1. Limited Scope: Click chemistry reactions are limited to specific types of reactions and functional groups. 2. Steric Hindrance: Click chemistry reactions can be affected by steric hindrance, which can reduce reaction efficiency. 3. Catalyst Requirements: Some click chemistry reactions require catalysts, which can add complexity to the reaction. 4. Scalability: Click chemistry reactions can be challenging to scale up due to the need for precise control over reaction conditions.

8. Any Questions