Common laboratory animals part 2

M. pharm unit 1

1. Common laboratory animals used in Drug Development Part- II Dr. K. Manohar Babu VJ’s College of Pharmacy Rajamahendravaram

2. Contents Types of animal models Non Rodent Animal Models Rabbit Monkey Cat Dog Miscellaneous Frog Zebra Fish Chicken Pigeon

3. INTRODUCTION Physiologically and Anatomically there is a similarity between the humans and animals at organs and organ systems, which function in a similar fashion. This similarity makes animals ideal models for the study and development of products and techniques for humans.

4. Animals used in Research Mammals Rodents Non Rodents Miscellaneous Mice, Rat, Guinea pig, Hamsters Rabbit, Dog, Cat, Monkey Pigeon, Zebra fish, Chicken

5. Non Rodents Animals Rabbit Monkey Cat Dog

6. Rabbits ( Oryctolagus cuniculus ) Domestic rabbits (2-3kg) are used for pyrogen testing. one of the peculiar thing about rabbits is that they are resistant to the action of atropine as they contain atropinesterase enzyme, the presence of which is genetically determined. Some of the tissue or organs from rabbits used are heart, aorta, duodenum and ileum.

7. Gestation : 30-33 days Parturition = Kindling Weaning : 4-6 weeks Offspring NZW : 8-10 kits Dutch : 5-6 kits Ovulation : Coitus Induced Estrus : Continuous Lifespan NZW : 5-6+ years Dutch : 5-10+ years

8. Use of Rabbit in Research Development of Rabis vaccine Bio assay of Diabetes drugs Hypertension Glaucoma Eye and ear infection Testing of Anti fertility agents Testing of cosmetics using Draize test

9. Rhesus monkey

10. Squirrel monkey Squirrel monkeys are small in size and ease of handling that contribute to their desirability as research subjects. The mean body weight of adult squirrel monkeys is less than 1 kg compared with female rhesus monkeys, which usually weigh 4 – 5 kg. Smaller doses necessary sp. Expensive medications easily adapt to laboratory housing

11. CAT (Felis catus )

12. DOG ( Canis familiaris )

13. Miscellaneous Animals Frog Zebra Fish Chicken Pigeon

14. FROG (Rana tigrine) New class of antibiotic compounds in frog skin called magainins .

15. ZEBRA FISH (Danio reiro )

16. CHICKEN (Gallus gallus )

17. PIGEON (Columbia livia )