comparation-cannabinoid-research-22.pptx

cannabinoid research

1. Outcome Scale No of articles Pain NRS 5 Daily average pain NRS 3 Daily worst pain NRS 3 Opioid maintenance dose MMEQ 5 Appetite nrs 1 Constipation nrs 2 qol eortc 1 sleep nrs 2 PGIC 3 RCT, THC:CBD Outcome Scale No of articles Pain NRS 1 Opioid maintenance dose MMEQ 1 Appetite NRS 2 qol eortc 2 Outcomes from eortc eortc 1 RCT, THC No of patients with improvement in O: 2 - 1 no comparator - 1 compared to prochlorperazine - 2 compared with placebo

2. Outcome Scale No of articles Pain NRS+nrs+esas+eortc+FACT 5+1 + 1+1+1 Daily average pain NRS 3 Daily worst pain NRS 3 Opioid maintenance dose MMEQ 5 +2 Appetite NRS+EASS+EORTC 1+1+1 Constipation Nrs+eortc 2+1 QOL Eortc+eortc+esas+FACT 1+1+1+1 sleep Nrs+eortc+FACT 2+1+1 PGIC (patient) 3+1 CGIC (clinician) 2+1 + 4 ongoing trials for thc:cbd -all 4 provide data for every outcome RCT, THC:CBD

3. CBD 2 have complete data only for pain THC 2 have complete data only for pain THC:CBD Number of articles Scale Role functioning (self care) 4 2 EORTC +1 EQ5D+1FACT Physical functioning (mobility) 5 2ROTC+1EQ5D+1MSAS+1FACT Social functioning (usual activities) 4 2 EORTC+1EQ5D+1FACT Emotional functioning (anxiety or depression) 4 2 EORTC+1 EQ5D+1MSAS Fatigue 3 2EORTC+1ESAS Pain 6 1NRS+2EORTC+2ESAS+1BDI Nausea 4 2EORTC+2ESAS Appetite 2 1EORTC+1ESAS Anxiety 4 2ESAS+1GAD+1eortc Sleep 3 2EORTC+2ESAS+1PSQI QOL 6 2EORTC+2ESAS+1EQ5D+1MSAS

4. CBD (all types of articles, no crossovers) No of articles Scale Pain 3 EQ-5D+ESAS/EORTC+BPI/ESAS THC (all types of articles, no crossovers) No of articles Scale Pain 4 NRS+ESAS+ESAS+ESAS/BPI Appetite 3 NRS+EORTC/NRS+ESAS QOL 3 ESAS+EORT+EORT Outcomes as no of patients with improvement No of articles Scale Nausea 5 (compared to placebo/nothing) No of events (2)+ 0-3 scale (1)+ NRS (1)+ complete/partial/no response (1) Vomiting 3 (compared to placebo/nothing) No of events (3)