Covalent Organic Frameworks (COF) Linkers | TCI Chemicals

Covalent organic frameworks (COFs) are crystalline organic frameworks consisting of a network structure made of covalent bonds. COFs are classified as porous crystalline materials similar to metal-organic frameworks (MOFs)/porous coordination polymers (PCPs) and zeolites. They include 2D COFs, which are constructed by stacking layers of 2D covalently bonded sheets, and 3D COFs, which are constructed by 3D connected frameworks. COFs are expected to be used as molecular storage or separation materials, catalysts, electronic materials, energy storage materials, battery materials, and drug delivery materials, due to their porosity, crystallinity, and structural diversity.

COFs are designed and synthesized by combining monomers, also called linkers, according to intended topology. TCI has more than 70 linkers in stock, and we are constantly adding new items to our catalog.

1. Covalent Organic Frameworks ( COF) linkers

2. Covalent organic frameworks (COFs) are crystalline organic frameworks consisting of a network structure made of covalent bonds . COFs are classified as porous crystalline materials similar to metal-organic frameworks (MOFs)/porous coordination polymers (PCPs) and zeolites . They include 2D COFs, which are constructed by stacking layers of 2D covalently bonded sheets, and 3D COFs, which are constructed by 3D connected frameworks.  COFs are designed and synthesized by combining monomers, also called linkers, according to intended topology.  TCI has more than 70 linkers in stock, and we are constantly adding new items to our catalog. Common linkers are shown below by functional groups. Introduction

3. Common linkers below by functional groups. Aldehyde Linkers Amine Linkers Carboxylic Anhydride Linkers Boronic Acid Linkers Other Linkers

4. Aldehyde Linkers A type of COFs based on imine linkage, synthesized by condensation of aldehydes and amines, was first reported in 2009,  and imine-based COFs have become the most widely reported COFs . One of the advantage of imine based COFs is their higher chemical stability compared to boroxines and boronate esters. In addition, a number of researchers have reported post-synthetic modification or functionalization of imine based COFs, e.g., COFs for CO2 capture were synthesized by post-synthetic modification and functionalization of imine-based structures. In 2012, β- ketoenamine -type COFs synthesized by using 2,4,6-triformylphloroglucinol (TPG, TFP) as an aldehyde linker were reported, and have recently attracted much attention because of their stability towards acids and bases. Continue…

5. Aldehyde Linkers - Products T0010 Terephthalaldehyde (= PDA) B2854 4,4'-Biphenyldicarboxaldehyde B6576 [2,2'-Bipyridine]-5,5'-dicarbaldehyde D5510 2,5-Dihydroxyterephthalaldehyde D6056 2,5-Dimethoxyterephthalaldehyde T4088 2,3,5,6-Tetrafluoroterephthalaldehyde T3688 2,4,6-Triformylphloroglucinol (= TFP, TPG) D6046 2,4,6-Triformylresorcinol B6003 1,3,5-Triformylbenzene F1252 1,3,5-Tris(4-formylphenyl)benzene T4077 2,4,6-Tris(4-formylphenoxy)-1,3,5-triazine Find More Aldehyde Linkers

6. Amine Linkers Amine linkers are used to synthesize imine-linked COFs by condensation of aldehydes and amines as described in the aldehyde linkers section, as well as imide-linked COFs mentioned in the carboxylic anhydride linkers section, and squaraine -linked COFs. Products P0170 1,4-Diaminobenzene P1691 2,5-Diaminobenzenesulfonic Acid D2893 [2,2'-Bipyridine]-5,5'-diamine D3180 2,6-Diaminoanthraquinone T2332 Tris(4-aminophenyl)amine (= TAPA) T2728 1,3,5-Tris(4-aminophenyl)benzene (= TAPB) T3695 4,4',4''-(1,3,5-Triazine-2,4,6-triyl)trianiline M3538 2,5,8-Triamino-1,3,4,6,7,9,9b-heptaazaphenalene T2947 Tetrakis(4-aminophenyl)methane T1494 5,10,15,20-Tetrakis(4-aminophenyl)porphyrin Find More Amine Linkers

7. Carboxylic Anhydride Linkers Imide-linked COFs obtained by condensation of carboxylic anhydrides and amines have also been reported and are expected to be applied to battery materials and CO 2  capture materials. B0040 Pyromellitic Dianhydride P2103 Pyromellitic Dianhydride (purified by sublimation) N1128 2,3,6,7-Naphthalenetetracarboxylic 2,3:6,7-Dianhydride N0369 Naphthalene-1,4,5,8-tetracarboxylic Dianhydride N0755 Naphthalene-1,4,5,8-tetracarboxylic Dianhydride (purified by sublimation) N1247 1,2,5,6-Naphthalenetetracarboxylic Dianhydride P0972 3,4,9,10-Perylenetetracarboxylic Dianhydride P2102 3,4,9,10-Perylenetetracarboxylic Dianhydride (purified by sublimation) M3617 Mellitic Trianhydride Products

8. Boronic Acid Linkers The self-condensation of boronic acids to produce boroxines and the condensation of boronic acids and catechols to produce boronic esters are the first synthetic strategies to synthesize COFs . P1358 1,4-Benzenediboronic Acid B2490 4,4'-Biphenyldiboronic Acid D4701 9,9-Dimethylfluorene-2,7-diboronic Acid Find More Boronic Acid Linkers

9. Other Linkers COFs constructed by linkers other than imines, imides, and boroxines are realized. These COFs are prepared using linkers other than amines, aldehydes, carboxylic anhydrides, and boronic acids. Examples: - Hydrazone -type COFs synthesized by hydrazines and aldehydes and ionic COFs synthesized using 1,2,3-triaminoguanidinium chloride are reported. - β- ketoenamine -type COFs with improved crystallinity and surface area, derived by synthesis of precursors with urea linkage and following "reconstruction" of β- ketoenamine -type COFs, have been reported. Products H0907 2,3,6,7,10,11-Hexahydroxytriphenylene (= HHTP) B6577 1,1'-([1,1'-Biphenyl]-4,4'-diyl) diurea T0758 Terephthalic Dihydrazide H0172 Hydrazine Monohydrate Find More Other Linkers

10. Related Products The following is a list of common reagents that are used as modulators to increase the crystallinity of the resulting COFs and as catalysts for the synthesis of COFs. Modulators Catalysts A0463 Aniline T0300 p-Toluidine B2379 Benzaldehyde B0857 Phenylboronic Acid B0739 4-tert-Butylpyrocatechol A2035 Acetic Acid T1663 Scandium(III) Triflate

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