CPCSEA & OECD GUIDELINES FOR LABORATORY ANIMAL B PHARMA.pptx

CPCSEA & OECD GUIDELINES FOR LABORATORY ANIMAL

1. CPCSEA & OECD GUI D EL I NES FOR LABORATORY ANIMAL BY Dr. SARITA SHARMA ASSOCIATE PROFESSOR DEPARTMENT OF PHARMACOLOGY MMCP, MMDU

2. CPCSEA Renamed as CCSEA Committee for the Purpose of Control and Supervision of Experiments on Animals  (CPCSEA ) Committee for Control and Supervision of Experiments on Animals  ( CCSEA )

3. WHY ANIMALS ARE USED IN RESEARCH

4. Reasons for human The principle of anatomy and physiology are true and , especially mammals . Certain strains or breeds of animals get the same disease or conditions as humans . With animals we can control their environment ( temperature , humidity, etc) and shield them from disease or condition not related to the research ( control their health ). We can use scientifically – valid no . of animals.

5. Animal procurement All animals must be acquired lawfully as per the CPCSEA guidelines . A health surveillance program for screening incoming animals should be carried out to assess animal quality . Methods of transportation should also be taken into account. Each consignment of animals should be inspected for compliance with procurement specifications, and the animals should be quarantined and stabilized according to procedures appropriate for the species and circumstances.

6. STABILIZATION AND SAPARATION STABILIZATION- Physiologic, psychological and nutritional stabilization should be given before their use . Duration of stabilization will depend on type and duration of animal transportation , and species of animal. SEPARATION- Physical separation of animal by species is recommended to prevent interspecies disease transmission and to eliminate anxiety and possible physiological and behavioural changes due to interspecies conflict . It shall be acceptable to house different species in the same room ,e.g. two species have a similar pathogen status and are behaviourally compatible.

7. TRAN S PORT O F LABOR A T O R Y ANIMALS The main considerations for transport of animals are the mode of transport , the containers, the animal density in cages, food and water during transit , protection from transit infection, injuries and stress.

8. ( eu =good . thanatos =death ) To stop the suffering End of experiment , to provide tissue for scientific purpose. Diseased animal or animal in bad condition

9. FOO D Should be fed palatable, non-contaminated and nutritionally adequate food. Diet should be free from heavy metals . BEDDING Absorbent, free of toxic chemicals or other substances that could injure animals or personnel Should be removed and replaced with fresh materials as often as necessary to keep animal clean and dry.

10. W A TER : Ordinarily animals should have continuous access to fresh, potable, uncontaminated drinking water, according to their particular requirements. SANITATION CLEANLIESS : Sanitation is essential in an animal facility. Animal rooms, corridors, storage spaces, and other areas should be cleaned with appropriate detergents and disinfectant .

11. Waste disposal Wastes should be removed regularly and frequently. All waste should be collected and disposed in a -safe and sanitary manner. The most preferred method of waste disposal is incineration . EMERGENCY, WEEKEND AND HOLIDAY CARE Animal should be cared for by qualified personnel every day, including weekends and holidays, to safeguards their well- being including emergency veterinary care