Cyanoborohydride

IMPORTANT REDUCTION REAGENT
USEFUL TO CSIR-NET PREPARATION STUDENTS AS WELL AS MSc CHEMISTRY STUDENTS

1. Use of NaBH 3 CN in Organic Synthesis ( Hydride ion transfer Reductions-III) Useful Concept to II M.Sc O rganic Chemistry, Semester-IV III BSc - IIT-JAM & CU-CET CSIR-NET/GATE exam students

2. Out lines of the Topic Sodium cyanoborohydride Introduction Preparation Applications Assignment

3. Introduction Sodium borohydride structure sodium cyanoborohydride is a colourless salt its chemical formula is Na B H 3 CN .

4. Sodium cyanoborohydride preparation NaBH 3 CN is less reactive reducing agent than sodium borohydride due to the presence of electron withdrawing cyano group. Preparation :Reaction of NaBH 4 with HCN gives NaBH 3 CN. It is soluble in THF, MeOH, H 2 O, HMPA and DMF solvents. NaBH 3 CN cannot reduce the aldehydes (or ) ketones in neutral condition but it reduces the protonated aldehydes and ketones at around pH 3 .

5. Main Applications-4 B.Sateesh Kumar Lecturer in chemistry GDC(M)-Srikakulam

6. B.Sateesh Kumar Lecturer in chemistry GDC(M)-Srikakulam

7. B.Sateesh Kumar Lecturer in chemistry GDC(M)-Srikakulam

8. B.Sateesh Kumar Lecturer in chemistry GDC(M)-Srikakulam

9. Assignment-IV 1.Write a short notes on NaBH 3 CN. 2.Write the any 4 important applications of NaBH 3 CN. 3.Write the preparation & use of NaBH 3 CN in organic synthesis 4.How to distinguish NaBH 4 with NaBH 3 CN

10. Thank you