Dengue_Natural_Course_Presentation.pptxx

dengue natural coarse

1. Dengue Viral Infection – Natural Course of Illness Compact Presentation

2. Clinical Spectrum Asymptomatic Symptomatic: - Undifferentiated fever (viral syndrome) - Dengue Fever (DF) - Dengue Haemorrhagic Fever (DHF) - Expanded Dengue Syndrome (rare; isolated organopathy)

3. Undifferentiated Fever Seen in primary dengue infection Simple fever, indistinguishable from other viral infections

4. Dengue Fever (DF) Acute febrile illness: headache, myalgia, arthralgia, rash Leucopenia, thrombocytopenia “Break-bone fever”: severe muscle/joint pain Rare bleeding: GI bleed, hypermenorrhea, massive epistaxis

5. Dengue Haemorrhagic Fever (DHF) Acute high fever → similar to DF initially Hallmark: Plasma leakage → risk of hypovolemic shock (DSS) Needs close monitoring

6. Clinical Course of DHF – Febrile Phase Duration: 2–7 days High fever, flushing, myalgia, nausea, vomiting Leucopenia & mild thrombocytopenia Tender hepatomegaly favors DHF

7. Clinical Course of DHF – Critical Phase Occurs 3rd–7th day, often with defervescence Plasma leakage → ↑ HCT (>20%), ↓ albumin, ↓ cholesterol Leakage into pleural/peritoneal spaces Severe leakage → shock, organ failure, DIC

8. Clinical Course of DHF – Convalescent Phase Duration: 2–5 days Fluid reabsorption, improved wellbeing Convalescent rash, itching (palms/soles), bradycardia, diuresis Platelet count rises, HCT stabilizes Risk: Fluid overload if excess IV fluids given

9. Key Takeaways Early detection of plasma leakage = lifesaving DHF is dynamic – requires vigilant monitoring Symptomatic management for DF/undifferentiated fever Overhydration in critical phase → pulmonary edema/pleural effusion