Diagnostic agents(D. pharmacy)

Agents used for radiographic purpose /Radiopaque substance
Iopanoic acid
Propyl iodone
2. Agents used to test organ function
Sulphobromopthalein sodium
Indigo carmine/ Indigotin disulphonate sodium
Evans blue
Congo red
Fluorescein sodium

1. DIAGNOSTIC AGENTS  By Shaikh Saniya M. Pharmacy

2.   INTRODUCTION Diagnostic agents are chemical or substances used to detect abnormalities in tissue and organs. Do not have medicinal & pharmacological effects X-ray film used for radiography

3. Classification Agents used for radiographic purpose /Radiopaque substance Iopanoic acid Propyl iodone 2. Agents used to test organ function Sulphobromopthalein sodium Indigo carmine/ Indigotin disulphonate sodium Evans blue Congo red Fluorescein sodium

4. 1.Agents used for radiographic purpose Also known as X-ray contrast. X-ray contrast media absorb radiation and provide shadow on X-ray film. Organs like gastrointestinal tract, gall bladder, kidney etc. can be map out.

5. a. Iopanoic acid This is simple butyric acid derivative. Iopanoic acid is used for diagnosis of gastrointestinal tract, gall bladder, kidney, bile duct, ureter.

6. Physical properties White or cream colored powder Tasteless Insoluble in water Soluble in ethanol, ether, and methanol. Storage : well closed and light resistant containers. Dosage form: Iopanoic acid tablets Brand name: telepaque

7. b. Propyl iodone Used for diagnostic agent for bronchial tract. Physical properties: White crystalline powder Odorless Slightly soluble in water Storage : well closed and light resistant containers.

8. Dosage form Injection Brand name : Dionosil

9. 2. Agents used to test organ function Sulphobromopthalein sodium Physical properties: White solid powder Odorless soluble in water Insoluble in alcohol Stability and Storage : It is hygroscopic hence it is stored in well closed and light resistant containers.

10. Uses Use for testing of liver function Diagnosis of hepatic disorder. Dosage form: Sulphobromopthalein injection

11. b. Indigo carmine Physical properties Purplish blue color powder or blue granules with coppery luster. Odorless Sparingly soluble Stability & Storage : It is affected by light. Hence it is stored in well closed and light resistant containers.

12. Uses It is used : To localize ureteral orifices during ureteral catheterization and cystoscopy. To test kidney function To identify ureters fistulous commutations Dosage form : Indigotin disulphonate injection Brand name: Indigo carmine

13. c. Evans blue It is azo dye. Physical properties: Green or bluish color crystal Odorless Soluble in water Insoluble in alcohol. Stability & Storage : It is hygroscopic. Hence it is stored in well closed and light resistant containers.

14. Uses It is used to diagnostic agent to determine blood volume Brand name: Evans blue injection

15. d. Congo red It is azo dye. Physical properties: reddish brown powder Odorless. Soluble in water. It decomposes on exposure to fumes of mineral acids

16. Stability & Storage : It is stored in well closed and light resistant containers. Uses It is used to treat amyloid disease. Dosage form : Congo red injection

17. e. Fluorescein sodium Physical properties: Orange red colored powder Odorless Tasteless Soluble in water Stability & Storage : It is hygroscopic. Hence it is stored in well closed and light resistant containers.

18. Uses Used in ophthalmic Detection of corneal lesion Detection of foreign particle in cornea.

19. Thankyou