Different between MHC class1 and MHC class2

This presentation will explain the following differences
Diagrammatically differences
Occurrences
Structures
Functions
Encoded chromosomes
Antigen-presenting Domains
Responsive Cells

1. Different between MHC class 1 and MHC class 2 Presented by M Kamil Khan Microbiologist

2. Content Diagrammatically differences Occurrences Structures Functions Encoded chromosomes Antigen-presenting Domains Responsive Cells

3. 1. Diagrammatically differences

4. 2 . Occurrences MHC Class I –  They are found on all nucleated cell types in the body. MHC Class II –  They are found on antigen presenting cells like macrophages, dendritic cells, and B cells.

5. 3. Structures MHC Class I –  They consist of 3 alpha domains and 1 beta domain. MHC Class II –  They consist of 2 alpha and beta domains.

6. 4. Function MHC Class I –  Their main role is to clear endogenous antigens that comes from the cytoplasm MHC Class II –  Their main role is to clear exogenous antigens that comes outside the foreign organisms

7. 5. Encoded Chromosomes MHC Class I –  Alpha domains are found on the locus of chromosome 6. On the other hand, beta chains are found on chromosome 15. MHC Class II –  They are found on chromosome 6.

8. 6. Antigen-presenting Domains MHC Class I –  Both alpha 1 and 2 domains have something to do with the presentation of antigens in the molecules of MHC class I . MHC Class II –  Both alpha 1 and beta 2 domains have something to do with the presentation of antigen in MHC Class II molecules.

9. 7. Responsive Cells MHC Class I –  Present antigens to cytotoxic T cells by binding on CD8 receptor on cytotoxic T cell MHC Class II –  Present antigens to helper T cells by binding on CD4 receptor on helper T cell

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