Dr. Raphael Ribeiro-Pinaud_ Visionary Leader Behind Antharis Therapeutics and Pioneering Advances in Oncology.pdf

Dr. Raphael Ribeiro-Pinaud is Chairman and CEO of Antharis Therapeutics and exemplifies the rare confluence of scientific depth, strategic acumen, and visionary leadership.

1. Dr. Raphael Ribeiro-Pinaud:
Visionary Leader Behind Antharis
Therapeutics and Pioneering
Advances in Oncology

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2. Cancer – arguably one of the most formidable adversaries in modern medicine –
continues to challenge clinicians, researchers, and patients alike. A diagnosis often
represents not just a medical emergency, but a life-altering moment with profound
emotional, physical, and societal implications. Delayed intervention can significantly
compromise outcomes, as the disease progresses, treatment options diminish, and the
window for effective action narrows. Amidst this complex landscape, leaders in healthcare and biotechnology emerge as
catalysts for change. These individuals drive innovation at the intersection of science
and compassion, shaping the future of cancer care. Dr. Raphael Ribeiro-Pinaud stands
prominently among them. As the founder and leading force behind Antharis
Therapeutics, he has dedicated his career to transforming the oncology paradigm –
accelerating the development of next-generation therapies designed to improve both
survival and quality of life for patients worldwide. Dr. Raphael Ribeiro-Pinaud is Chairman and CEO of Antharis Therapeutics and
exemplifies the rare confluence of scientific depth, strategic acumen, and visionary
leadership. With a robust background spanning biomedical research, biotechnology
investment, and executive management, Dr. Ribeiro-Pinaud has been steering Antharis
to the forefront of next-generation oncology and immuno-oncology innovation. He
exemplifies the rare blend of scientific rigor and visionary thinking required to translate
cutting-edge discoveries into accessible, life-saving treatments. His leadership not only
advances the frontiers of oncology but also brings renewed hope to patients and
families confronting the harsh realities of cancer.
Under his leadership, Antharis has been emerging as a cutting-edge biotechnology
enterprise dedicated to advancing transformative cancer therapeutics. His strategic
direction has catalyzed the development of novel biotherapies – most notably
monoclonal and bispecific antibodies, as well as antibody-drug conjugates (ADCs) –
engineered to selectively kill cancer cells and overcome the mechanisms by which
tumors evade immune detection and destruction. Dr. Raphael Ribeiro-Pinaud’s commitment to scientific rigor is matched by his dedication
to translational impact. He has cultivated a culture of innovation anchored in rigorous
science and shaped by strategic partnerships, ensuring that high-potential therapies

3. progress efficiently from bench to bedside. With the company’s inaugural clinical trials
almost underway, Antharis stands poised to deliver first-in-class and best-in-class
treatments capable of redefining outcomes for patients with otherwise intractable
cancers.
Bridging the Translational Divide in Biotherapeutic Innovation
DDr. Raphael Ribeiro-Pinaud founded Antharis Therapeutics with a singular mission: to
bridge the translational gap in biotherapeutic drug development and accelerate the
transformation of cutting-edge science into clinically meaningful cancer therapies. With
a multidisciplinary background Dr. Ribeiro-Pinaud brings a uniquely integrated
perspective to one of the industry’s most persistent challenges – advancing promising
scientific discoveries through the complex, often fragmented, development pipeline. Having navigated the scientific, financial, strategic and operational contours of the
biotech ecosystem, Dr. Raphael Ribeiro-Pinaud is acutely aware of the structural
inefficiencies that impede progress – ranging from misaligned incentives and
undercapitalized early-stage programs to inconsistent strategic execution. Antharis was
conceived as a solution to these barriers: a company designed to de-risk early
innovation, streamline translational development, and bring high-impact therapies to the
clinic, to patients with urgency. His leadership philosophy is anchored in scientific rigor, capital and operational
efficiencies, and a culture of unrelenting innovation. Informed by his successful tenure
at multiple biotechnology ventures, Dr. Raphael Ribeiro-Pinaud understands that
scientific ingenuity must be coupled with disciplined execution, thoughtful resource
allocation, and a mission-driven team. At Antharis, this philosophy drives the
development of therapeutic platforms with both strong clinical potential and meaningful
commercial viability – ensuring that transformative science does not remain in the
laboratory, but instead reaches the patients and communities who need it most.
A Commitment to Transforming Cancer Care
Antharis Therapeutics is a top emerging company at the forefront of developing
next-generation oncology and immuno-oncology therapies, the latter designed to

4. overcome one of cancer’s most formidable defenses – its capacity to evade immune
surveillance. Through a scientifically rigorous and strategically integrated approach, the
company is advancing an extensive portfolio of highly targeted therapeutics aimed at
reshaping the treatment landscape for patients with difficult-to-treat malignancies.
Central to Antharis’ innovation strategy is the development of monoclonal and bispecific
antibodies, and antibody-drug conjugates (ADCs), engineered to deliver potent
anti-tumor activity while minimizing off-target effects. These precision therapies are
designed not only to enhance efficacy but also to reduce the toxicities commonly
associated with traditional cancer treatments. Robust preclinical studies have
demonstrated compelling safety and efficacy profiles, laying the groundwork for pivotal
clinical trials that promise to accelerate therapeutic impact. Antharis employs a biomarker-driven development model, enabling refined patient
selection to improve response rates and maximize clinical success. This approach
reflects a commitment to personalized medicine – ensuring that the right patients
receive the right therapies at the right time. Further strengthening its translational
capabilities, the company has established strategic collaborations with leading partners
to support co-development initiatives and expedite the path to commercialization. By uniting cutting-edge science with disciplined execution and strategic alliances,
Antharis is redefining the future of cancer therapy – advancing the promise of oncology
and immuno-oncology from the laboratory to the lives of patients worldwide.
Integrating Artificial Intelligence to Redefine Drug Development
In certain critical elements of its workflow , Antharis Therapeutics leverages the
transformative power of artificial intelligence to redefine the drug development
paradigm – enhancing precision and accelerating timelines. By embedding AI and
advanced computational technologies, the company is utilizing an efficient and
data-driven approach to therapeutic innovation. In particular, advanced analytical tools
enhance antibody humanization and molecular design, optimizing therapeutic profiles
for maximal efficacy.

5. Through the incorporation of artificial intelligence into its scientific infrastructure,
Antharis is not only improving the speed and success of drug development but also
ensuring that groundbreaking therapies reach patients with greater precision and
efficacy.
Addressing the Structural Challenges of Oncology Drug Development
Oncology remains one of the most complex and high-risk domains within biotechnology
and pharmaceutical development, characterized by elevated failure rates, protracted
timelines to commercialization, and intense competitive pressures. A significant
proportion of investigational therapies falter due to suboptimal early-stage data,
inadequate patient stratification, or the emergence of unanticipated safety concerns –
issues that collectively hinder translational success and limit clinical impact. Antharis Therapeutics confronts these challenges with a biomarker-driven development
strategy that prioritizes precision from the outset. By aligning therapeutic design with
patient-specific biological signatures, the company enhances treatment efficacy,
mitigates safety risks, and increases the probability of clinical and regulatory success.
This approach not only improves outcomes but also optimizes development efficiency
by ensuring that promising therapies are matched with the populations most likely to
benefit. Recognizing the financial and operational demands of bringing oncology therapies to
market, Antharis implements a disciplined resource allocation framework. The company
strategically focuses on high-impact, clinically validated programs while maintaining
lean operational structures – thereby maximizing therapeutic value while minimizing
capital risk.
In the increasingly saturated field of oncology, differentiation is imperative. Antharis
distinguishes itself through a portfolio of next-generation antibodies and antibody-drug
conjugates (ADCs), engineered for enhanced specificity , potency, and immune
engagement. These modalities are designed to maximize cancer cell killing and
circumvent tumor immune evasion, a central obstacle in cancer treatment, offering a
novel therapeutic advantage. Strategic collaborations further accelerate clinical
development and streamline the pathway to commercialization.

6. Through the integration of cutting-edge science, fiscal discipline, and robust partnership
networks, Antharis is redefining oncology innovation – advancing transformative
therapies that deliver not only clinical breakthroughs but sustained value for patients,
providers, and stakeholders alike.
Strategic Partnerships and Co-Development: Expanding Therapeutic
Reach Through Collaboration
Antharis Therapeutics recognizes that meaningful innovation in oncology is rarely
achieved in isolation. Strategic partnerships – whether through co-development
agreements, licensing arrangements, or joint ventures – are central to the company’s
mission to accelerate therapeutic advancement, enhance operational capabilities, and
ensure timely patient access to transformative treatments.
By expanding collaborating efforts with leading research institutions, cutting-edge
technology providers, and pharmaceutical companies, Antharis enhances the
translational velocity of its pipeline – advancing investigational therapies from
early-stage development through clinical validation and ultimately to market. These
partnerships provide critical expertise in areas such as advanced biologics, regulatory
strategy, and global commercialization, enabling the company to scale its impact
beyond traditional boundaries. Each alliance is carefully structured to align with Antharis’ scientific priorities and
strategic vision, ensuring that every collaboration drives measurable progress in
oncology innovation. As the company transitions into the clinical development phase, it
remains actively engaged in forging partnerships that amplify its capabilities, accelerate
timelines, and generate enduring value for both patients and stakeholders.
Through a collaborative model grounded in scientific excellence and strategic
alignment, Antharis is building a robust and resilient pipeline – positioned to deliver
life-changing therapies and shape the future of cancer care.
A Testament to Strategic Execution and Translational Expertise

7. Antharis Therapeutics’ advancement into a clinical-stage company marks a pivotal
milestone in its evolution and underscores the organization’s capacity to translate
scientific innovation into tangible therapeutic impact. This year, the initiation of
first-in-human clinical trials for its lead candidates represents not only a significant
achievement in drug development but also a validation of Antharis’ strategic vision,
operational discipline, and scientific rigor. The transition from preclinical discovery to clinical evaluation is a defining inflection
point for any biotechnology enterprise – requiring a convergence of robust preclinical
data, regulatory precision, and thoughtful resource allocation. Antharis’ successful
progression to this stage is a reflection of its integrated approach: uniting
groundbreaking science with capital-efficient execution and a relentless focus on
patient-centered outcomes. This milestone embodies the company’s founding philosophy – advancing highly
differentiated therapies while building a sustainable and scalable business model. It
affirms Antharis’ commitment to delivering innovation that is both clinically meaningful
and commercially viable. As the company continues to advance its pipeline through
clinical development, its mission remains clear: to bring life-changing therapies to
patients, while generating enduring value for partners, investors, and the broader
healthcare ecosystem. Harmonizing Innovation, Growth, and Patient-Centered Impact
Enduring success in biotechnology hinges on the deliberate integration of scientific
innovation, sustainable business growth, and meaningful patient outcomes – three
interdependent pillars that, when aligned, drive transformative change. At Antharis
Therapeutics, this synergy forms the foundation of the company’s mission and
operational philosophy.
Anchored in cutting-edge science, Antharis is addressing critical gaps in oncology
treatment through the development of bispecific and monoclonal antibodies, and
antibody-drug conjugates (ADCs). These precision-engineered therapies are guided by a
biomarker-driven development strategy, ensuring rigorous validation, refined patient

8. selection, and a direct translation of laboratory breakthroughs into clinically effective,
differentiated treatments.
Yet scientific excellence must be paired with strategic foresight to reach patients.
Antharis embraces a capital-efficient model focused on high-impact assets with clear
pathways to clinical and commercial success. Through targeted investments and
disciplined portfolio management, the company advances therapies with strong
therapeutic potential and market relevance. Strategic collaborations, co-development
initiatives, and licensing partnerships with leading pharmaceutical organizations hold
the promise to further accelerate development while expanding access and preserving
long-term value.
At the heart of Antharis’ approach is an unwavering commitment to patient impact.
Every decision – from trial design and regulatory strategy to commercialization
planning—is shaped by a focus on improving patient outcomes. By harmonizing
innovation, operational discipline, and patient-centricity, Antharis is not only building a
next-generation oncology company, but redefining what it means to bring scientific
discovery to life.
A Visionary Commitment to Patient-Centered Innovation
Under the visionary leadership of Dr. Raphael Ribeiro-Pinaud, Antharis Therapeutics
stands at the vanguard of oncology innovation, driven by a mission to redefine cancer
treatment through scientific excellence, strategic execution, and an unwavering
commitment to patients. Dr. Raphael Ribeiro-Pinaud has cultivated a leadership
philosophy that integrates five foundational principles – innovation, collaboration,
operational excellence, adaptability, and patient focus – into the company’s strategic
and operational core. Innovation serves as the engine of progress at Antharis, where cutting-edge science
fuels the development of next-generation cancer therapies designed to address some of
the most urgent and complex challenges in oncology. Collaboration is equally essential,
as the company actively partners with leading experts, institutions, and industry
stakeholders to accelerate discovery and development through shared expertise and
complementary capabilities.

9. Operational excellence is embedded in Antharis’ approach to growth, with data-driven
strategies and disciplined resource management ensuring that innovation is both
sustainable and scalable. In an industry defined by rapid evolution and inherent risk,
adaptability is crucial; Antharis navigates the dynamic biotech landscape with agility,
proactively responding to scientific, regulatory, and market shifts.
Most critically, patient focus remains the guiding force behind every decision. From
early research through clinical development and commercialization, the company’s
efforts are aligned with a singular objective: to improve patient outcomes and expand
access to life-changing therapies.
By harmonizing these principles within a cohesive, patient-centered strategy, Antharis is
not only advancing the frontiers of oncology but also reshaping the future of cancer
care – delivering real-world impact for patients, healthcare systems, and global
communities alike.
Transitioning from Clinical to Commercial Stage
Over the next few years, Antharis Therapeutics is poised to strengthen its position as a
top emerging clinical-stage biotech company, advancing the development of
next-generation oncology therapies while laying the groundwork for successful
commercialization. The company’s strategy is anchored in scientific innovation,
strategic alliances, and a deep commitment to delivering transformative treatments that
address unmet medical needs on a global scale. Central to Antharis’ approach is the continued advancement of its clinical trials, with a
focus on rigorously evaluating and optimizing promising assets. This commitment to
excellence in clinical development ensures that the company remains on track to meet
critical milestones and move its therapies from the laboratory to patients with the
utmost precision and efficacy. As part of its broader vision, Antharis is actively
expanding its pipeline by integrating novel scientific discoveries that will give rise to
innovative oncology therapies, further solidifying its leadership in the field. The company is also placing significant emphasis on strengthening its collaborations
with top pharmaceutical organizations, aiming for co-development agreements and

10. global expansion. These strategic partnerships will not only accelerate the progress of
Antharis’ pipeline but also enhance its capabilities in reaching markets worldwide. In
parallel, Antharis is focused on transitioning from clinical development to
commercialization by building the necessary infrastructure and internal expertise
required for a seamless move to market.
Ultimately, Antharis is working to establish a strong market presence in oncology by
positioning itself as a leader in precision-driven cancer therapies. This multi-pronged
strategy will enable the company to deliver meaningful impact to patients while creating
lasting value for stakeholders in the years to come.
Guidance for Emerging Leaders in Healthcare
Dr. Raphael Ribeiro-Pinaud offers valuable advice to aspiring healthcare innovators,
urging them to embark on a journey that is as challenging as it is rewarding, marked by
both setbacks and triumphs. Achieving success in this field necessitates the integration
of scientific expertise, adaptability, and collaborative spirit – each element playing an
indispensable role in driving transformative progress. While innovation serves as the
catalyst for change, true breakthroughs are often born from a foundation of curiosity,
rigorous data analysis, and patient-centered decision-making. Collaboration with industry experts accelerates the development of therapies that have
the potential to reshape treatment paradigms, while adaptability becomes crucial in
navigating inevitable obstacles and strategically pivoting when necessary. However, the
journey from discovery to patient impact requires more than just scientific excellence;
business acumen is equally essential. Leaders must be adept at securing funding,
navigating regulatory landscapes, and ensuring the successful commercialization of
novel treatments. Above all, Dr. Raphael Ribeiro-Pinaudd emphasizes that the ultimate goal of healthcare
innovation should always be to improve patient outcomes. Every scientific achievement
must be measured by its real-world impact, with each breakthrough advancing the
standard of care and providing tangible benefits to those in need. The future of
healthcare will be determined by those who push the boundaries of knowledge, foster
collaborative partnerships, and remain steadfast in their commitment to improving lives.