Enzyme induction and repression

the process of enzyme induction and repression based on operon concept

1. Enzyme induction and repression By S.Srividhya III Biochemistry

2. What is Enzyme Induction ? A process in which a molecule (e.g. a drug) induces (i.e. initiates or enhances) the expression of an enzyme . An enzyme inducer is a type of drug which binds to an enzyme and increases its metabolic activity. Regulated by exposure to drugs and environmental chemicals leading to increased rates of metabolism. Example: lac operon

3. Enzymes that are susceptible to  induction  are said to be “inducible” enzymes kick into production when needed, remain dormant otherwise . Enzyme  induction  can increase the metabolic clearance of a concomitantly administered drug, resulting in reduced efficacy , which may comprise the therapeutic effectiveness of a drug. 

4. What is Enzyme Repression ? Effectors can associate with the operator and alter the configuration so that the binding of the polymerase occurs less efficiently or not at all. This effect is known as repression. Example : trp operon Feedback inhibition Prevents wasting of energy

5. Importance of enzyme induction Essential to understand various reactions that occur inside the body Important to analyse drug reaction Study toxicity Causes less or over production of hormones

6. I nducer molecule merges with ‘ repressor ’-induction Repressor binds to ‘operator’-repression

7. References: http:// www.innovateus.net/health/what-enzyme-induction https:// www.youtube.com/watch?v=7qiBMpU_Xik