Fatty liver- General metabolism, biochemistry

Fatty liver, causes, lipotropic factors, types of fatty liver.
Alcoholism, NAFLD, karyorrhexis, summary of lipid metabolism.

1. Fatty liver
Biochemistry

4. Role of liver in fat metabolism
•Secretion of bile salts
•Synthesis of fatty acid, triacylglycerols(transported as VLDL in
blood) and phospolipids.
•Oxidation of fatty acids
•Production of lipoproteins
•Production of ketone bodies
•Synthesis and excretion of cholesterol.

8. Excess calorie intake
Excess calories in the form of carbohydrates
Deposited as fat
Obesity accompanied by fatty liver

9. ALCOHOLISM
Most common cause
Alcohol oxidized to acetaldehyde
Increased quantities of NADH
NADH converts oxaloacetate to malate
FA accumulates because of deficiency of OAA(oxidation of acetyl CoA through
TCA cycle is reduced)

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