FBD FLUIDIZED BED DRYER

DRYING FBD that is used to dry granules

1. Fluidized Bed Dryer (FBD) AMAN VYAWAHARE 4 th yr. BPHARM (P.R.POTE.PATIL COLLAGE OF PHARMACY AMRAVAT) 1

2. Contents INTRODUCTION PRINCIPLE CONSTRUCTION WORKING TYPES OF FBD ADVANTAGES DISADVANTAGES APPLICATION VALIDATION 2

3. Introduction : Fluidized bed dryer (FBD) is well known and widely used equipment in the pharmaceutical manufacturing . The direct contact between particles and air is possible in fluid bed system It is used in granulation process for drying the material to get desired moisture content in the granules required for perfect compression of tablet formulation. 3

4. Principle The main principle involved in fluidized bed dryer is FLUIDIZATION Hot air is passed at high speed through a perforated bottom of the container containing granules The granules are lifted from the bottom and suspended in the stream of air this condition is called “fluidized state”. 4

5. CONSTRUCTION: Made up of stainless steel Detachable bowl Fan Fresh air inlet, heat exchanger Bag filter 5

6. 6 WORKING: Granules are placed Hot air flows through the bottom Granules rise and the fall back Condition: fluidized state

7. 7 Air leaves Drying is achieved Time for drying

8. TYPES : 8 1. Batch type fluidized bed dryer

9. 9 2. Continuous fluid bed dryer

10. ADVANTAGES : High rates of moisture removal Low capital and maintenance cost Highly efficient in material drying Handling is easy Wide range No hot spot on the product Suitable for both 10

11. DIS-ADVANTAGES : Poor fluidization and low flexibility Not the best choice of equipment Entertainment of fine particles Product loss Sticky material is quite difficult 11

12. Application: Drying of the granules in the production of the tablet Coating of the tablet Agriculture , pharma, food ,dairy Polymer film coating Drying moist (DCPA) Top spray granulators Formulation , development and production 12

13. VALIDATION protocol: A Validation Protocol is an approved document which outlines the program to be employed, the tests that will be made and the acceptance criteria for those tests. Validation Phases : DQ- Design Qualification IQ- Installation Qualification OQ-Operational Qualification PQ- Performance Qualification 13

14. DESIGN QUALIFICATION In fluidized bed dryer the design of the instrument should be : occupy the small place. Based on our requirement we can go for horizontal or vertical. kept in mind while doing the design. Every fluid bed dryer must have explosion relief device . 14

15. INSTALLATION QUALIFICATION: 15 Verifying the approved purchase order model number, serial number Ensure all documentation is received Check the manufacturer and supplier. Check for any physical damage. Confirm location and installation Dust free area and moisture free air should be provided. Installation shall be conducted per instructions provided in the manual.

16. OPERATIONAL QUALIFICATION: 16 Verify alarm control. Operate the equipment at low, medium, and high speed Verify that all switches and push buttons are functioning properly. procedures training program electrical fittings

17. PERFORMANCE QUALIFICATION: Run the trial batch during the: 1. Size 2. Shape 3.Surface of the material which we kept for drying. 17

18. MAKERS OF FBD: 18 Tapasya Engineering works Pvt Ltd. Chitra Machineries Pvt Ltd. NU Pharma Engineers And Consultant. Chamunda Pharma Machinery Pvt. Ltd.

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