Fluidized bed processing

The main principle involved in the FBP is the air suspension in which the material to be coated is suspended in the coating material with the help of an air stream. A fluid bed processor (fbp) is a popular material processing technique in different field industries.

1. 1 P. R. Pote Patil College of Pharmacy, Amravati Fluidized Bed Processor (FBP ) Prepared & Presented by : Prof. Vedanshu R. Malviya ( M.pharm )

2. 2 Fluidized Bed Processor (FBP)

3. Contents INTRODUCTION PRINCIPLE APPLICATIONS OF FLUID BED PROCESSING COMPONENTS WORKING ADVANTAGES DISADVANTAGES APPLICATION REFERENCES 3

4. Introduction Fluidized bed processor (FBP) is well known and widely used equipment in the pharmaceutical manufacturing . The direct contact between particles and air is possible in fluid bed system. It is used in granulation process for drying the material to get desired moisture content in the granules required for perfect compression of tablet formulation. 4

5. 5 The principle involved in such techniques may be either by bottom spray or top spray. These principles depend on the positioning of the spray gun in the equipment. The top spray process helps in achieving the uniform granulation. The bottom spray process uses a Wurster coating unit for the spray ( Leuenberger , 1990).

6. Principle The main principle involved in fluidized bed dryer is FLUIDIZATION Hot air is passed at high speed through a perforated bottom of the container containing granules The granules are lifted from the bottom and suspended in the stream of air this condition is called “fluidized state”. 6

7. Applications of Fluid bed processing Granulation & Drying 7

8. Agglomeration & Pelletization . 8 Powder coating (Functional Coating)

9. COMPONENTS 9 Inlet Exhaust Control Panel Bottom Plate Spray Nozzle Peristaltic Pump Finger bag Product Bowl

10. 10 WORKING : Material to be dried is placed in the bowl type vessel. Air is introduced from the top and heated at required temperature by the heaters. The air is filtered through the filter and then passes through the bed of the material at the bottom. The airflow is generated by the fans fitted at the top of the equipment. The air flow rate and the operating temperature are adjusted by the control panel.

11. 11 As the flow of air increases, the bed expands and particles of powder start to rise up. The regular contact with air causes the material to dry. The air leaving the FBD passes through the filter to collect the fine particles of the material. Fluidized bed dryer has a high drying rate and the material is dried in a very short time. Material remains free-flowing and uniform. FBD bags have finger-like shape to increase the volume of the drying bed that helps to increase the drying rate and decrease the drying time.

12. ADVANTAGES : High rates of moisture removal. Highly efficient in material drying. Handling is easy. Wide range of materials can be formulated. 12

13. DISADVANTAGES : Product loss. Sticky material is quite difficult. High capital and maintenance cost. Skilled person required 13

14. Application: Drying of the granules in the production of the tablet Coating of the tablet Agriculture , pharma, food & Dairy. Polymer film coating Drying moist Top spray granulators Formulation , development and production 14

15. MAKERS OF FBD: 15 Tapasya Engineering works Pvt Ltd. Chitra Machineries Pvt Ltd. NU Pharma Engineers And Consultant. Chamunda Pharma Machinery Pvt. Ltd.

16. 16 REFERENCES Lachman L, Lieberman H.A, Kanig JL, Third edition “Granulation” , The Theory and practice of industrial pharmacy,Verghese Publishing House, Bombay, 5859, 1991 Leuenberger H, Luy B, Struder J, New development in the control of a moist agglomeration and pelletization process, STP Pharma Sci, 6, 1990, 303-309. Ylirussi J, Rasanen E, Rantanen J, Mannermaa JP, The characterization of Fluidization Behavior Using a Novel Multichamber Microscale Fluid Bed, J. Pharma Sci, 3, 2004, 780-791. Gu L, Liew CV, Heng PW. Wet spheronization by rotary processing: a multistage single-pot process for producing spheroids. Drug Dev Ind Pharm, 30, 2004, 111-123. Ansel C, Allen LV, Popovich NG, Pharmaceutical dosage form and Drug delivery system, Edn 8, B.I Publications, India, 193, 2005, 243. Ravi Teja Pusapati*, T. Venkateswara Rao, Fluidized bed processing: A review, Indian Journal of Research in Pharmacy and Biotechnology ISSN: 2321-5674(Print) ISSN: 2320 – 3471(Online)

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