Friability test ppt

Friable: “ A friable substance is any substance that can be reduced to finer particles by the action of a small pressure or friction, such as rubbing or inadvertently brushing up against the substance”.
Friability test: Defined as the % of weight loss by tablets due to mechanical action during the test. Tablets are weighing before & after testing & friability is expressed as a percentage loss on pre-test tablet weight. & Friability test is done to check the ability of the compressed tablet to avoid fracture & breaking during the transport.
This testing involves repeatedly dropping a sample of tablets over a fixed time, using a rotating wheel with a baffle. The result is inspected for broken tablets, and the percentage of tablet mass lost through chipping.
If the average weight of the tablet is 0.65gm or less. Take 10 times of the whole weight i.e., 6.5 gm

2. Carefully deducts the tablets & weight required numbers of tablets.
Initial weight = 6.536gm
3. Set the Time duration for 4min
4. Set number of counts to 100
5. Make sure the drum is cleaned with no contaminates ,
add the initial weighted tables carefully & close the lid
6. Click Start button

Drum diameter : 283 -291mm
Depth: 36-40mm
Inner radius of the curve projection : 75.5mm – 85.5mm
Outer diameter of the central ring : 24.5mm – 25.5mm
Rotation Speed : 25 +/_ 1 cycle
Time Set: 4 min
After 4min automatically it stops ,
7. Take out the tablets & take out the dust from the tablets using brush /crumps
8. Take the After weight of the tablets
Total weight of after rotation= 6.443gm

Interpretation :
Value of friability should not be more than 1% for most of tablets.
If the value of friability for the first is greater than 1%, then repeat the test twice & mean of three values is taken.
If the mean value of three tests is less than 1% tablets passes the friability test,
otherwise tablet fails the test.
If the tablets are broken , chipped or cracked during the test, the tablets fails the friability test.

By ArcImBioCLinica (AIBC)

1. TOPIC: FRIABILITY

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2. FRIABILITY

Eriable : “ A friable substance is any substance that can be reduced to finer
Particles by the action of a small pressure or friction, such as rubbing or
inadvertently brushing up against the substance”.

Eriability Test : Defined as the % of weight loss by tablets due to mechanical action
duringthe test. Tablets are weighing before & after testing & friability is expressed as
a percentage loss on pre test tablet weight.

& Friability testis done to check the ability ofthe compressed tablet to avoid fracture
& breaking during the transport

3. FRIABILITY

EA]

ROCHE FRIABILATOR (2)

This testing involves repeatedly dropping a sample of tablets over a fixed
time, using a rotating wheel with a baffle. The result is inspected for
broken tablets, and the percentage of tablet mass lost through chipping.

4. FRIABILITY

Applicable for compressed uncoated tablets & intended to determine the strength of tablet
during transportation & storage the tablets should retain its shape & size.

Method:

Drum diameter : 283 -29imm

Depth: 36-40mm

Inner radius of the curve projection : 75.5mm - 85,5mm
Outer diameter of the central ring : 24.5mm—25,5mm
Rotation Speed : 25+/_ 1 cycle

Time Set: 4 min

ROCHE FRIABILATOR (2)

5. To determine the friability

1. ifthe average weight of the tablet is 0.65gm or less Take 10 timesof the whole
weight i.e,6.5gm

2. Carefully deducts thetablets
& weight required numbers oftablets.

Initialweight=6.536gm

6. 3. Setthe Time duration for 4min

4. Set number of countsto 100

7. 5. Make surethedrum iscleanedwithno contaminates,
add the initial weightedtablescarefully & closethe lid

6. Click Start button

Drum diameter : 283 -291mm

Depth: 36-40mm

Inner radius of the curve projection: 75.5mm
—85.5mm

Outer diameter of the central ring: 24.5mm—
25.5mm

Rotation Speed :25+/_1 cycle

Time Set: 4 min

8. 7. After 4min automaticaly it stops,
Take out thetablets & take out the dust from the tablets using brush /crumps

8. Take the After weight of thetablets

Total weight of after rotation=6.443gm

9. Calculation of friability

10. Interpretation :

¥ Walueoffriability should not bemorethan 1% for most of tablets.
¥ ifthe value of friability for the first is greater than 1%, then repeat the test twice&
mean ofthreevalues istaken.

Y Ifthe mean value of three tests is less than 1% tablets passes the friability test,

Y otherwisetablet fais thetest.

Ifthe tablets are broken , chipped or cracked during thetest, thetablets fails.
the friability test.

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Arcim Bio Clinica

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