Fungal keratitis(1).pptx ocular Microbiology

Ocular Microbiology

1. Fungal keratitis

2. Cornea Round Convex Transparent structure having 5 layers Refractive Power is 43D

3. Fungal keratitis Fungal keratitis is an infection of cornea caused by a fungus There are two main types of Fungus that can cause keratitis: Filamentous (e.g Aspergillus) Non-Filamentous ( e.g Yeast)

4. Risk Factors Ocular Factors Contact Lense Chronic ocular Surface disease Chronic Trauma Corneal Surgery Systematic Factors Diabetes HIV Hypertension leprosy

5. Signs and Symptoms Symptoms Mild pain Irritation Watering and Presence of yellow patch in the cornea Signs A typical lesion is a yellow white colour marginal ulcer Dry in appearance with small satelite lesions Finger like hyphates edges into adjacent stroma Ulcer margin is often elevated above the surface

6. Basic Principle Of Treatment: 1. Scraping and debridement of the ulcer is useful in drug penetration. 2. 1% Atropine eyedrop or ointment controls associated iritis and prevents synechiae formation 3. Antifungal drugs-The available antifungal drugs are mainly fungistatic.

7. Treatment Medical Treatment Anti-fungal Drugs Surgical Treatment Debridment and Superficial keratocomy Keratoplasty Flap Removal Cauterization

8. Anti-fungal Therapeutics Amphotericin B Ketoconazole Miconazole Clotrimazol

9. Differentiate Between Fungal keratitis Fungal keratitis is often associated with trauma from plant material or organic matter Fungal keratitis often manifests with feathery or filamentous infiltrates and may exhibit satellite lesions. Fungal keratitis requires treatment with antifungal agents such as voriconazole or natamycin. Bacterial keratitis Bacterial keratitis can result from contact lens wear, corneal abrasions, or ocular surface diseases Bacterial keratitis usually presents with more discrete borders and may have a purulent discharge Bacterial keratitis is typically treated with topical antibiotics