Global bio bank

Basic knowledge about GLOBAL BIO BANK

1. Global Bio Bank Presented By: Dr. Meghana Ghodake

2. GLOBAL BIO BANK:c Organized collection and storage of human biological samples and Associated data of great significance for research And personalized medicine. Bio bank consists of 3 types of Information = 1. Attached or connected information 2. The consent and patinets individual data safety and protection 3. Biospecimens BIOSPECIMENS : It includes Amnoitic fluid,Bone marrow stem cells and tissues,fresh frozen plasma ,RNA ,DNA,protein ,Cerebrospinal fluid,blood ,urine,Synovial fluid,blood etc.

3. BIOBANKING MAIN COMPONENTS 1.Biologic material handling - Biospecimen Collection - Biospecimen Processing - Biospecimen Storage - Biospecimen Distribution 2.Database management system ‐ Informed consent ‐ Medical history and personal information ‐ life style data ‐ confidentiality ‐ Security

4. BIOBANK HISTORY The history of Biobank is not long. The collection and Storage of human tissue has been part of medical research For nearly a century. The term “BioBank”first appeared in the late 1990s. After 10 years broad term is evolved

5. BIOREPOSITARY : A biological repository that collects ,process,store and provides Biospecimens to future scientific research. Biorepositary can contain specimens from Animals,human other living organisms . PROCESS OF BIOBANKING:

6. Types of BIOBANK

7. STORAGE OF SAMPLES : DNA,Serum,Plasma and Blood stored at ‐80degreeC. Tissue and cell lines are preserved in liquid nitrogen freezers at ‐196degreeC. BEST PRACTISES OF BIOBANKS: Goal of biobank is to collect,store and disseminate specimens and related data. Publications discussing best practises: International Society Of Biological and Environmental Repositories National Cancer Institute. BIOBANK POPULATION GROUP: 1.Whole Population 2.Subset of Population

8. BBMRI ‐Biobanking &Biomolecular Resources Research Infrastructure Funded by ERIC (European Research Infrstructure Consortium) . Largest research Infrastructure project in Europe It will form interface between specimens and data and top level biological and medical research.

9. Centralized Vs Federated BioBanking: BioBank In India: ‐Brain Biobank,NIMHANS Bangalore . ‐Tata Memorial Hospital Tissue Bank. ‐Narayana Hrudayala Tissue Bank &Stem cell research Centre.

10. biobank BIOBANK: ETHICAL ISSUES For tissue banking freely given informed patient Consent is mandatory. Patient consent forms needs to be upgraded from time to time following IRB regulations. Confidentiality ‐very important aspect Safety is crucial: material safety data sheet(MSDS)to be distributed among staff for entire chemical Compounds kept at the biobank