Glycyrrhiza glabra (Liquorice)

Liquorice
Pharmacognosy
Pharmacology

1. Glycyrrhiza glabra

2. CONTENT Introduction Uses Constituents Side Effects Mechanism of Action Toxicity Dosage Drug Interactions Contraindications

3. INTRODUCTION FAMILY LEGUMINACEAE BOTANICAL NAME GLYCERYIZA GLABRA L. ENGLISH NAME LIQUORICE URDU NAME MULHATI PART USED ROOTS,RHIZOME

4. CONSTITUENTS Other Components Glycyrrhizinic Acid 20% Glycrrhizin Glabranin A & B Glycyrrhetol Glabrolide Isoflavones Coumarins Triterpene Sterols Active ingriedients Glycyrrhizinic Acid 10%

5. TOXICITY Hypokalemic Paralysis Cardiac Myopathy Metabolic Alkalosis Hypoxemia Pseduoaldosteronism

6. USES Antiviral Anti-cancer Anti-inflammatory Cardiac Dental Diabetes GI Complaints Hormonal Effects Hepatoprotection

7. MECHANISM OF ACTION Hypocholester-olemic action Anti mutagenic Activity Decrease Lipid Peroxidation Stimulate Hormones Free Radical Scavenging Activity

8. SIDE EFFECTS Salt Retention Water Retention Low Potassium level Hypertension Cardiac dysfunctions Disturbance in cortisol level

9. DOSAGE LICORICE ROOTS Licorice Roots Doses Varies Between 2-15 g f or Ulcer And Gastritis Glycyrrhizin Is Suggested To Be 0.2 Mg/Kg/Day

10. DRUG INTERACTION Interaction With Warfarin Licorice Decreases Effectiveness Of Warfarin Increasing Risk Of Clotting Interaction With Digoxin Licorice Decreases Potassium Levels Which Increase Side Effects Of Digoxins It May Altar Prednisolone Plasma Concentration

11. CONTRAINDICATIONS Licorice might interfere with blood pressure control during and after surgery. Stop taking licorice at least 2 weeks before a scheduled surgery. It may effect the kidneys also .so don’t use it during kidney problems. It may lower the potassium levels in the blood. Thus causing hypokalemia. Licorice has the ability to store water in the body, thus it can make congestive heart failure worse. Surgery: Licorice might interfere with blood pressure control during and after surgery. Stop taking licorice at least 2 weeks before a scheduled surgery. It may also cause problems in the kidneys.so do not take licorice during kidney problems. It may lower the potassium levels in the blood causing hypokalemia. Licorice can store water in the body, thus cause a severe congestive heart failure.so be careful while using.

12. REFERENCES www.herblist.com www.ncbi.nlm.nih.gov www.drhmeo.com www.henrietess-herb.com book of medical pharmacology American medicinal plants  

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